Ontology: Molecular Function (GO:0008094)

Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.

Synonyms: adenosinetriphosphatase (DNA-dependent); DNA dependent ATPase activity; DNA-dependent adenosinetriphosphatase activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term DNA-dependent ATPase activity (21 genes) or to its variants containing one or more qualifiers (3 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	contributes_to: DNA-dependent ATPase activity	3
	DNA-dependent ATPase activity	14
High-throughput	none	none
Computational (download data)	DNA-dependent ATPase activity	10

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term DNA-dependent ATPase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

DNA-dependent ATPase activity      21 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CHD1/YER164W	IDA: Inferred from Direct Assay Assigned on 2011-10-03	manually curated	Tran HG, et al.  (2000) The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor. EMBO J 19(10):2323-31	SGD
DMC1/YER179W	IEA: Inferred from Electronic Annotation with EBI:IPR020587, EBI:IPR020588, EBI:IPR011940 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
FUN30/YAL019W	IMP: Inferred from Mutant Phenotype Assigned on 2012-10-04	manually curated	Neves-Costa A, et al.  (2009) The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. PLoS One 4(12):e8111	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-11-29	manually curated	Awad S, et al.  (2010) The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme. J Biol Chem 285(13):9477-84	SGD
MSH1/YHR120W	IDA: Inferred from Direct Assay Assigned on 2006-08-16	manually curated	Chi NW and Kolodner RD  (1994) The effect of DNA mismatches on the ATPase activity of MSH1, a protein in yeast mitochondria that recognizes DNA mismatches. J Biol Chem 269(47):29993-7	SGD
MSH2/YOL090W	IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR11361_AN24 Assigned on 2010-07-15	computational	Gaudet P, et al.  (2011) Annotation inferences using phylogenetic trees.	RefGenome
MSH3/YCR092C	IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR11361_AN24 Assigned on 2010-07-15	computational	Gaudet P, et al.  (2011) Annotation inferences using phylogenetic trees.	RefGenome
MSH4/YFL003C	IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR11361_AN24 Assigned on 2010-07-15	computational	Gaudet P, et al.  (2011) Annotation inferences using phylogenetic trees.	RefGenome
MSH5/YDL154W	IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR11361_AN24 Assigned on 2010-07-15	computational	Gaudet P, et al.  (2011) Annotation inferences using phylogenetic trees.	RefGenome
MSH6/YDR097C	IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR11361_AN24 Assigned on 2010-07-15	computational	Gaudet P, et al.  (2011) Annotation inferences using phylogenetic trees.	RefGenome
RAD26/YJR035W	IDA: Inferred from Direct Assay Assigned on 2007-03-16	manually curated	Guzder SN, et al.  (1996) RAD26, the yeast homolog of human Cockayne's syndrome group B gene, encodes a DNA-dependent ATPase. J Biol Chem 271(31):18314-7	SGD
RAD5/YLR032W	IDA: Inferred from Direct Assay Assigned on 2007-12-20	manually curated	Blastyak A, et al.  (2007) Yeast rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression. Mol Cell 28(1):167-75	SGD
RAD51/YER095W	IDA: Inferred from Direct Assay Assigned on 2006-11-14	manually curated	Sung P  (1994) Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein. Science 265(5176):1241-3	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR020587, EBI:IPR020588, EBI:IPR011941 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RAD54/YGL163C	IDA: Inferred from Direct Assay Assigned on 2002-08-14	manually curated	Petukhova G, et al.  (1999) Yeast Rad54 promotes Rad51-dependent homologous DNA pairing via ATP hydrolysis-driven change in DNA double helix conformation. J Biol Chem 274(41):29453-62	SGD
RAD55/YDR076W	ISS: Inferred from Sequence or structural Similarity with SGD:RAD51 Assigned on 2006-11-14	manually curated	Lovett ST  (1994) Sequence of the RAD55 gene of Saccharomyces cerevisiae: similarity of RAD55 to prokaryotic RecA and other RecA-like proteins. Gene 142(1):103-6	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR020588 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RAD57/YDR004W	ISS: Inferred from Sequence or structural Similarity with SGD:RAD51 Assigned on 2006-11-14	manually curated	Lovett ST  (1994) Sequence of the RAD55 gene of Saccharomyces cerevisiae: similarity of RAD55 to prokaryotic RecA and other RecA-like proteins. Gene 142(1):103-6	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR020588 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RDH54/YBR073W	IDA: Inferred from Direct Assay Assigned on 2002-08-14	manually curated	Petukhova G, et al.  (2000) Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1. Genes Dev 14(17):2206-15	SGD
SEN1/YLR430W	ISS: Inferred from Sequence or structural Similarity with EBI:Q92355 Assigned on 2007-08-31	manually curated	Kim HD, et al.  (1999) The sen1(+) gene of Schizosaccharomyces pombe, a homologue of budding yeast SEN1, encodes an RNA and DNA helicase. Biochemistry 38(44):14697-710	SGD
SNF2/YOR290C	IDA: Inferred from Direct Assay Assigned on 2008-05-13	manually curated	Cairns BR, et al.  (1994) A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast. Proc Natl Acad Sci U S A 91(5):1950-4	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2008-05-13	manually curated	Cote J, et al.  (1994) Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex. Science 265(5168):53-60	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2006-03-27	manually curated	Laurent BC, et al.  (1993) The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation. Genes Dev 7(4):583-91	SGD
STH1/YIL126W	IDA: Inferred from Direct Assay Assigned on 2012-04-25	manually curated	Du J, et al.  (1998) Sth1p, a Saccharomyces cerevisiae Snf2p/Swi2p homolog, is an essential ATPase in RSC and differs from Snf/Swi in its interactions with histones and chromatin-associated proteins. Genetics 150(3):987-1005	SGD
	IDA: Inferred from Direct Assay Assigned on 2007-01-24	manually curated	Saha A, et al.  (2002) Chromatin remodeling by RSC involves ATP-dependent DNA translocation. Genes Dev 16(16):2120-34	SGD
TOP2/YNL088W	IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR10169_AN0 Assigned on 2011-01-03	computational	Gaudet P, et al.  (2011) Annotation inferences using phylogenetic trees.	RefGenome
ULS1/YOR191W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-05-22	manually curated	Zhang Z and Buchman AR  (1997) Identification of a member of a DNA-dependent ATPase family that causes interference with silencing. Mol Cell Biol 17(9):5461-72	SGD

contributes_to: DNA-dependent ATPase activity      3 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
RAD16/YBR114W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Guzder SN, et al.  (1998) The DNA-dependent ATPase activity of yeast nucleotide excision repair factor 4 and its role in DNA damage recognition. J Biol Chem 273(11):6292-6	SGD
RAD7/YJR052W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Guzder SN, et al.  (1998) The DNA-dependent ATPase activity of yeast nucleotide excision repair factor 4 and its role in DNA damage recognition. J Biol Chem 273(11):6292-6	SGD
RSC1/YGR056W	IC: Inferred By Curator from RSC complex, ISS: Inferred from Sequence or structural Similarity with SGD:RSC2 Assigned on 2007-02-01	manually curated	Cairns BR, et al.  (1999) Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol Cell 4(5):715-23	SGD

SGD Home About Blog Site Map Help Terms of Use
© Stanford University, Stanford, CA 94305.