GO term: pheromone-dependent signal transduction involved in conjugation with cellular fusion 
Ontology: Biological Process (GO:0000750)
Definition: A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
Synonyms: transduction of mating signal
Definition: A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
Synonyms: transduction of mating signal
This table lists the methods used to annotate genes either directly to the term
pheromone-dependent signal transduction involved in conjugation with cellular fusion (29 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | pheromone-dependent signal transduction involved in conjugation with cellular fusion | 29 |
| High-throughput | none | none |
| Computational (download data) | pheromone-dependent signal transduction involved in conjugation with cellular fusion | 2 |
Links to Additional Annotations:
Annotation details for genes that have been directly annotated to the term
pheromone-dependent signal transduction involved in conjugation with cellular fusion or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| pheromone-dependent signal transduction involved in conjugation with cellular fusion 29 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AFR1/YDR085C | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-12-06 |
manually curated | Davis C, et al. (1998) Afr1p regulates the Saccharomyces cerevisiae alpha-factor receptor by a mechanism that is distinct from receptor phosphorylation and endocytosis. Genetics 148(2):625-35 |
SGD |
| AKR1/YDR264C | IGI: Inferred from Genetic Interaction Assigned on 2002-12-06 |
manually curated | Kao LR, et al. (1996) Interactions between the ankyrin repeat-containing protein Akr1p and the pheromone response pathway in Saccharomyces cerevisiae. Mol Cell Biol 16(1):168-78 |
SGD |
| BNI1/YNL271C | IMP: Inferred from Mutant Phenotype Assigned on 2007-02-01 |
manually curated | Qi M and Elion EA (2005) Formin-induced actin cables are required for polarized recruitment of the Ste5 scaffold and high level activation of MAPK Fus3. J Cell Sci 118(Pt 13):2837-48 |
SGD |
| CDC24/YAL041W | IGI: Inferred from Genetic Interaction, IPI: Inferred from Physical Interaction, TAS: Traceable Author Statement Assigned on 2002-12-06 |
manually curated | Nern A and Arkowitz RA (1999) A Cdc24p-Far1p-Gbetagamma protein complex required for yeast orientation during mating. J Cell Biol 144(6):1187-202 |
SGD |
| CDC42/YLR229C | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06 |
manually curated | Moskow JJ, et al. (2000) Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae. Mol Cell Biol 20(20):7559-71 |
SGD |
| FAR1/YJL157C | IGI: Inferred from Genetic Interaction, IPI: Inferred from Physical Interaction, TAS: Traceable Author Statement Assigned on 2002-12-06 |
manually curated | Nern A and Arkowitz RA (1999) A Cdc24p-Far1p-Gbetagamma protein complex required for yeast orientation during mating. J Cell Biol 144(6):1187-202 |
SGD |
| FUS3/YBL016W | IDA: Inferred from Direct Assay Assigned on 2002-12-06 |
manually curated | Errede B, et al. (1993) MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro. Nature 362(6417):261-4 |
SGD |
| GET3/YDL100C | IMP: Inferred from Mutant Phenotype Assigned on 2008-05-05 |
manually curated | Lee MJ and Dohlman HG (2008) Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol 18(3):211-5 |
SGD |
| GPA1/YHR005C | IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06 |
manually curated | Miyajima I, et al. (1987) GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell 50(7):1011-9 |
SGD |
| KSS1/YGR040W | IEP: Inferred from Expression Pattern, IMP: Inferred from Mutant Phenotype Assigned on 2007-07-24 |
manually curated | Sabbagh W Jr, et al. (2001) Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation. Mol Cell 8(3):683-91 |
SGD |
| MDG1/YNL173C | IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06 |
manually curated | Leberer E, et al. (1996) Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity. Mol Gen Genet 252(5):608-21 |
SGD |
| MF(ALPHA)1/YPL187W | IMP: Inferred from Mutant Phenotype Assigned on 2006-10-18 |
manually curated | Kurjan J (1985) Alpha-factor structural gene mutations in Saccharomyces cerevisiae: effects on alpha-factor production and mating. Mol Cell Biol 5(4):787-96 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR016326 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB | |
| MF(ALPHA)2/YGL089C | IMP: Inferred from Mutant Phenotype Assigned on 2006-10-18 |
manually curated | Kurjan J (1985) Alpha-factor structural gene mutations in Saccharomyces cerevisiae: effects on alpha-factor production and mating. Mol Cell Biol 5(4):787-96 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR016326 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB | |
| MFA1/YDR461W | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06 |
manually curated | Michaelis S and Herskowitz I (1988) The a-factor pheromone of Saccharomyces cerevisiae is essential for mating. Mol Cell Biol 8(3):1309-18 |
SGD |
| MFA2/YNL145W | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06 |
manually curated | Michaelis S and Herskowitz I (1988) The a-factor pheromone of Saccharomyces cerevisiae is essential for mating. Mol Cell Biol 8(3):1309-18 |
SGD |
| PTP2/YOR208W | TAS: Traceable Author Statement Assigned on 2002-12-06 |
manually curated | Mattison CP, et al. (1999) Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3. Mol Cell Biol 19(11):7651-60 |
SGD |
| PTP3/YER075C | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-12-06 |
manually curated | Zhan XL, et al. (1997) Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae. Genes Dev 11(13):1690-702 |
SGD |
| RGA1/YOR127W | IGI: Inferred from Genetic Interaction Assigned on 2002-12-06 |
manually curated | Stevenson BJ, et al. (1995) Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae. Genes Dev 9(23):2949-63 |
SGD |
| RGA2/YDR379W | TAS: Traceable Author Statement Assigned on 2002-12-06 |
manually curated | Johnson DI (1999) Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev 63(1):54-105 |
SGD |
| SCP160/YJL080C | IGI: Inferred from Genetic Interaction with SGD:GPA1 Assigned on 2006-04-27 |
manually curated | Guo M, et al. (2003) The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160. Mol Cell 12(2):517-24 |
SGD |
| STE11/YLR362W | IMP: Inferred from Mutant Phenotype Assigned on 2007-03-05 |
manually curated | Zhou Z, et al. (1993) Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases. Mol Cell Biol 13(4):2069-80 |
SGD |
| STE18/YJR086W | IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06 |
manually curated | Whiteway M, et al. (1988) Function of the STE4 and STE18 genes in mating pheromone signal transduction in Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol 53 Pt 2:585-90 |
SGD |
| STE2/YFL026W | IMP: Inferred from Mutant Phenotype Assigned on 2007-07-12 |
manually curated | Jenness DD, et al. (1987) Saccharomyces cerevisiae mutants unresponsive to alpha-factor pheromone: alpha-factor binding and extragenic suppression. Mol Cell Biol 7(4):1311-9 |
SGD |
| STE20/YHL007C | IGI: Inferred from Genetic Interaction with SGD:STE4, IMP: Inferred from Mutant Phenotype Assigned on 2007-04-25 |
manually curated | Leberer E, et al. (1992) The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components. EMBO J 11(13):4815-24 |
SGD |
| STE3/YKL178C | IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-12-06 |
manually curated | Hagen DC, et al. (1986) Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor. Proc Natl Acad Sci U S A 83(5):1418-22 |
SGD |
| STE4/YOR212W | IGI: Inferred from Genetic Interaction, IPI: Inferred from Physical Interaction Assigned on 2002-12-06 |
manually curated | Nern A and Arkowitz RA (1999) A Cdc24p-Far1p-Gbetagamma protein complex required for yeast orientation during mating. J Cell Biol 144(6):1187-202 |
SGD |
| STE5/YDR103W | IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction Assigned on 2002-12-06 |
manually curated | Choi KY, et al. (1994) Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78(3):499-512 |
SGD |
| STE50/YCL032W | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-12-06 |
manually curated | Xu G, et al. (1996) Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae. Mol Microbiol 20(4):773-83 |
SGD |
| STE7/YDL159W | TAS: Traceable Author Statement Assigned on 2002-12-06 |
manually curated | Errede B, et al. (1995) Dynamics and organization of MAP kinase signal pathways. Mol Reprod Dev 42(4):477-85 |
SGD |
This diagram shows the local area of the Gene Ontology and the numbers of yeast genes annotated to each term in the diagram. Within the diagram, click on the blue arrow to navigate up the tree and click on a GO term name to go to its GO term page.
View term lineage as a textual display using
View term lineage as a textual display using