Ontology: Biological Process (GO:0000750)

Definition: A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.

Synonyms: transduction of mating signal

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term pheromone-dependent signal transduction involved in conjugation with cellular fusion (26 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	pheromone-dependent signal transduction involved in conjugation with cellular fusion	26
High-throughput	none	none
Computational (download data)	pheromone-dependent signal transduction involved in conjugation with cellular fusion	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term pheromone-dependent signal transduction involved in conjugation with cellular fusion or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

pheromone-dependent signal transduction involved in conjugation with cellular fusion      26 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ADF1/YCL058W-A	IMP: Inferred from Mutant Phenotype Assigned on 2010-03-10	manually curated	Li D, et al.  (2010) A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand. Cell Res 20(4):408-20	SGD
AFR1/YDR085C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-12-06	manually curated	Davis C, et al.  (1998) Afr1p regulates the Saccharomyces cerevisiae alpha-factor receptor by a mechanism that is distinct from receptor phosphorylation and endocytosis. Genetics 148(2):625-35	SGD
CDC42/YLR229C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06	manually curated	Moskow JJ, et al.  (2000) Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae. Mol Cell Biol 20(20):7559-71	SGD
FAR1/YJL157C	IGI: Inferred from Genetic Interaction, IPI: Inferred from Physical Interaction, TAS: Traceable Author Statement Assigned on 2002-12-06	manually curated	Nern A and Arkowitz RA  (1999) A Cdc24p-Far1p-Gbetagamma protein complex required for yeast orientation during mating. J Cell Biol 144(6):1187-202	SGD
FUS3/YBL016W	IDA: Inferred from Direct Assay Assigned on 2002-12-06	manually curated	Errede B, et al.  (1993) MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro. Nature 362(6417):261-4	SGD
FYV5/YCL058C	IMP: Inferred from Mutant Phenotype Assigned on 2010-03-10	manually curated	Li D, et al.  (2010) A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand. Cell Res 20(4):408-20	SGD
GET3/YDL100C	IMP: Inferred from Mutant Phenotype Assigned on 2008-05-05	manually curated	Lee MJ and Dohlman HG  (2008) Coactivation of G protein signaling by cell-surface receptors and an intracellular exchange factor. Curr Biol 18(3):211-5	SGD
GPA1/YHR005C	IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06	manually curated	Miyajima I, et al.  (1987) GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell 50(7):1011-9	SGD
KSS1/YGR040W	IEP: Inferred from Expression Pattern, IMP: Inferred from Mutant Phenotype Assigned on 2007-07-24	manually curated	Sabbagh W Jr, et al.  (2001) Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation. Mol Cell 8(3):683-91	SGD
MDG1/YNL173C	IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06	manually curated	Leberer E, et al.  (1996) Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity. Mol Gen Genet 252(5):608-21	SGD
MF(ALPHA)1/YPL187W	IMP: Inferred from Mutant Phenotype Assigned on 2006-10-18	manually curated	Kurjan J  (1985) Alpha-factor structural gene mutations in Saccharomyces cerevisiae: effects on alpha-factor production and mating. Mol Cell Biol 5(4):787-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR016326 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MF(ALPHA)2/YGL089C	IMP: Inferred from Mutant Phenotype Assigned on 2006-10-18	manually curated	Kurjan J  (1985) Alpha-factor structural gene mutations in Saccharomyces cerevisiae: effects on alpha-factor production and mating. Mol Cell Biol 5(4):787-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR016326 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MFA1/YDR461W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06	manually curated	Michaelis S and Herskowitz I  (1988) The a-factor pheromone of Saccharomyces cerevisiae is essential for mating. Mol Cell Biol 8(3):1309-18	SGD
MFA2/YNL145W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06	manually curated	Michaelis S and Herskowitz I  (1988) The a-factor pheromone of Saccharomyces cerevisiae is essential for mating. Mol Cell Biol 8(3):1309-18	SGD
PTC1/YDL006W	IMP: Inferred from Mutant Phenotype Assigned on 2010-08-12	manually curated	Malleshaiah MK, et al.  (2010) The scaffold protein Ste5 directly controls a switch-like mating decision in yeast. Nature 465(7294):101-5	SGD
RGA1/YOR127W	IGI: Inferred from Genetic Interaction Assigned on 2002-12-06	manually curated	Stevenson BJ, et al.  (1995) Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae. Genes Dev 9(23):2949-63	SGD
RGA2/YDR379W	TAS: Traceable Author Statement Assigned on 2002-12-06	manually curated	Johnson DI  (1999) Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev 63(1):54-105	SGD
SCP160/YJL080C	IGI: Inferred from Genetic Interaction with SGD:GPA1 Assigned on 2006-04-27	manually curated	Guo M, et al.  (2003) The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160. Mol Cell 12(2):517-24	SGD
STE11/YLR362W	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-05	manually curated	Zhou Z, et al.  (1993) Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases. Mol Cell Biol 13(4):2069-80	SGD
STE18/YJR086W	IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06	manually curated	Whiteway M, et al.  (1988) Function of the STE4 and STE18 genes in mating pheromone signal transduction in Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol 53 Pt 2:585-90	SGD
STE2/YFL026W	IMP: Inferred from Mutant Phenotype Assigned on 2007-07-12	manually curated	Jenness DD, et al.  (1987) Saccharomyces cerevisiae mutants unresponsive to alpha-factor pheromone: alpha-factor binding and extragenic suppression. Mol Cell Biol 7(4):1311-9	SGD
STE20/YHL007C	IGI: Inferred from Genetic Interaction with SGD:STE4, IMP: Inferred from Mutant Phenotype Assigned on 2007-04-25	manually curated	Leberer E, et al.  (1992) The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components. EMBO J 11(13):4815-24	SGD
STE3/YKL178C	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-12-06	manually curated	Hagen DC, et al.  (1986) Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor. Proc Natl Acad Sci U S A 83(5):1418-22	SGD
STE4/YOR212W	IGI: Inferred from Genetic Interaction, IPI: Inferred from Physical Interaction Assigned on 2002-12-06	manually curated	Nern A and Arkowitz RA  (1999) A Cdc24p-Far1p-Gbetagamma protein complex required for yeast orientation during mating. J Cell Biol 144(6):1187-202	SGD
STE5/YDR103W	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction Assigned on 2002-12-06	manually curated	Choi KY, et al.  (1994) Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78(3):499-512	SGD
STE50/YCL032W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-12-06	manually curated	Xu G, et al.  (1996) Ste50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae. Mol Microbiol 20(4):773-83	SGD

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