Ontology: Biological Process (GO:0007265)

Definition: A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.

Synonyms: Ras mediated signal transduction

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term Ras protein signal transduction (14 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	Ras protein signal transduction	14
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

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• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term Ras protein signal transduction or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

Ras protein signal transduction      14 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
BMH1/YER177W	IGI: Inferred from Genetic Interaction Assigned on 2001-08-29	manually curated	Roberts RL, et al.  (1997) 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae. Cell 89(7):1055-65	SGD
BMH2/YDR099W	IGI: Inferred from Genetic Interaction Assigned on 2001-08-29	manually curated	Roberts RL, et al.  (1997) 14-3-3 proteins are essential for RAS/MAPK cascade signaling during pseudohyphal development in S. cerevisiae. Cell 89(7):1055-65	SGD
CDC25/YLR310C	IMP: Inferred from Mutant Phenotype Assigned on 2011-02-16	manually curated	van Aelst L, et al.  (1991) Involvement of the CDC25 gene product in the signal transmission pathway of the glucose-induced RAS-mediated cAMP signal in the yeast Saccharomyces cerevisiae. J Gen Microbiol 137(2):341-9	SGD
CYR1/YJL005W	IGI: Inferred from Genetic Interaction with SGD:RAS1, SGD:RAS2 Assigned on 2007-07-18	manually curated	Kataoka T, et al.  (1985) DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell 43(2 Pt 1):493-505	SGD
ERI1/YPL096C-A	IMP: Inferred from Mutant Phenotype Assigned on 2005-11-22	manually curated	Sobering AK, et al.  (2003) A novel Ras inhibitor, Eri1, engages yeast Ras at the endoplasmic reticulum. Mol Cell Biol 23(14):4983-90	SGD
RAS1/YOR101W	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Broek D, et al.  (1985) Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell 41(3):763-9	SGD
RAS2/YNL098C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Broek D, et al.  (1985) Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell 41(3):763-9	SGD
RPI1/YIL119C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Kim JH and Powers S  (1991) Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function. Mol Cell Biol 11(8):3894-904	SGD
SDC25/YLL016W	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Shirayama M, et al.  (1994) Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1. Yeast 10(4):451-61	SGD
SRV2/YNL138W	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Nishida Y, et al.  (1998) Coiled-coil interaction of N-terminal 36 residues of cyclase-associated protein with adenylyl cyclase is sufficient for its function in Saccharomyces cerevisiae ras pathway. J Biol Chem 273(43):28019-24	SGD
TPK1/YJL164C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Cannon JF and Tatchell K  (1987) Characterization of Saccharomyces cerevisiae genes encoding subunits of cyclic AMP-dependent protein kinase. Mol Cell Biol 7(8):2653-63	SGD
	IGI: Inferred from Genetic Interaction with SGD:CDC25, SGD:CYR1, SGD:RAS1, SGD:RAS2 Assigned on 2007-05-14	manually curated	Toda T, et al.  (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50(2):277-87	SGD
TPK2/YPL203W	IGI: Inferred from Genetic Interaction with SGD:CDC25, SGD:CYR1, SGD:RAS1, SGD:RAS2, ISS: Inferred from Sequence or structural Similarity with SGD:TPK1 Assigned on 2007-05-14	manually curated	Toda T, et al.  (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50(2):277-87	SGD
TPK3/YKL166C	IGI: Inferred from Genetic Interaction with SGD:CDC25, SGD:CYR1, SGD:RAS1, SGD:RAS2, ISS: Inferred from Sequence or structural Similarity with SGD:TPK1 Assigned on 2007-05-14	manually curated	Toda T, et al.  (1987) Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50(2):277-87	SGD
YLL017W	TAS: Traceable Author Statement Assigned on 2004-06-17	manually curated	Shirayama M, et al.  (1994) Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1. Yeast 10(4):451-61	SGD

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