GO term: double-strand break repair via homologous recombination 
Ontology: Biological Process (GO:0000724)
Definition: The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
Synonyms: homologous recombinational repair; HRR; Rhp51-dependent recombinational repair; Rad51-dependent recombinational repair; HDR; homology-directed repair
View Ontology:
(graph) | 
(text)
Definition: The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
Synonyms: homologous recombinational repair; HRR; Rhp51-dependent recombinational repair; Rad51-dependent recombinational repair; HDR; homology-directed repair
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
double-strand break repair via homologous recombination (18 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | double-strand break repair via homologous recombination | 15 |
| High-throughput | none | none |
| Computational (download data) | double-strand break repair via homologous recombination | 4 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
double-strand break repair via homologous recombination or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| double-strand break repair via homologous recombination 18 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| BRE1/YDL074C | IGI: Inferred from Genetic Interaction with SGD:RAD50 Assigned on 2009-11-11 |
manually curated | Game JC, et al. (2006) The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18. Genetics 173(4):1951-68 |
SGD |
| CTF18/YMR078C | IMP: Inferred from Mutant Phenotype Assigned on 2008-11-07 |
manually curated | Ogiwara H, et al. (2007) Ctf18 is required for homologous recombination-mediated double-strand break repair. Nucleic Acids Res 35(15):4989-5000 |
SGD |
| ELG1/YOR144C | IMP: Inferred from Mutant Phenotype Assigned on 2006-12-18 |
manually curated | Ogiwara H, et al. (2007) Role of Elg1 protein in double strand break repair. Nucleic Acids Res 35(2):353-62 |
SGD |
| ESC2/YDR363W | IGI: Inferred from Genetic Interaction with SGD:RAD51, SGD:SHU1, SGD:MPH1, SGD:SGS1, IMP: Inferred from Mutant Phenotype Assigned on 2009-01-30 |
manually curated | Mankouri HW, et al. (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1683-94 |
SGD |
| MMS21/YEL019C | IEA: Inferred from Electronic Annotation with EBI:IPR026846 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| PPH3/YDR075W | IGI: Inferred from Genetic Interaction with SGD:PTC2, SGD:PTC3 Assigned on 2011-05-13 |
manually curated | Kim JA, et al. (2011) Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination. Mol Cell Biol 31(3):507-16 |
SGD |
| RAD1/YPL022W | IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR10150_AN0 Assigned on 2010-09-24 |
computational | Gaudet P, et al. (2011) Annotation inferences using phylogenetic trees. |
RefGenome |
| RAD6/YGL058W | IGI: Inferred from Genetic Interaction Assigned on 2009-11-11 |
manually curated | Game JC, et al. (2006) The RAD6/BRE1 histone modification pathway in Saccharomyces confers radiation resistance through a RAD51-dependent process that is independent of RAD18. Genetics 173(4):1951-68 |
SGD |
| RFA1/YAR007C | IGI: Inferred from Genetic Interaction with SGD:SPO11 Assigned on 2006-12-22 |
manually curated | Gasior SL, et al. (1998) Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes. Genes Dev 12(14):2208-21 |
SGD |
| RFA2/YNL312W | IGI: Inferred from Genetic Interaction with SGD:SPO11 Assigned on 2006-12-22 |
manually curated | Gasior SL, et al. (1998) Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes. Genes Dev 12(14):2208-21 |
SGD |
| RFA3/YJL173C | IGI: Inferred from Genetic Interaction with SGD:SPO11 Assigned on 2006-12-22 |
manually curated | Gasior SL, et al. (1998) Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes. Genes Dev 12(14):2208-21 |
SGD |
| RSC2/YLR357W | IMP: Inferred from Mutant Phenotype Assigned on 2012-03-05 |
manually curated | Chai B, et al. (2005) Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair. Genes Dev 19(14):1656-61 |
SGD |
| SGS1/YMR190C | IGI: Inferred from Genetic Interaction with SGD:SHU1, SGD:MPH1, SGD:ESC2, IMP: Inferred from Mutant Phenotype Assigned on 2009-01-30 |
manually curated | Mankouri HW, et al. (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1683-94 |
SGD |
| SMC5/YOL034W | IEA: Inferred from Electronic Annotation with EBI:IPR027131 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| SMC6/YLR383W | IMP: Inferred from Mutant Phenotype Assigned on 2011-09-21 |
manually curated | De Piccoli G, et al. (2006) Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol 8(9):1032-4 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR027132 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| SNF5/YBR289W | IMP: Inferred from Mutant Phenotype Assigned on 2012-03-05 |
manually curated | Chai B, et al. (2005) Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair. Genes Dev 19(14):1656-61 |
SGD |
| YKU70/YMR284W | IMP: Inferred from Mutant Phenotype Assigned on 2002-11-01 |
manually curated | Cervelli T and Galli A (2000) Effects of HDF1 (Ku70) and HDF2 (Ku80) on spontaneous and DNA damage-induced intrachromosomal recombination in Saccharomyces cerevisiae. Mol Gen Genet 264(1-2):56-63 |
SGD |
| YKU80/YMR106C | IMP: Inferred from Mutant Phenotype Assigned on 2002-11-01 |
manually curated | Cervelli T and Galli A (2000) Effects of HDF1 (Ku70) and HDF2 (Ku80) on spontaneous and DNA damage-induced intrachromosomal recombination in Saccharomyces cerevisiae. Mol Gen Genet 264(1-2):56-63 |
SGD |
