Ontology: Biological Process (GO:0007165)

Definition: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Synonyms: signaling cascade; signalling cascade; signalling pathway; signaling pathway

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term signal transduction (70 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	signal transduction	30
High-throughput	none	none
Computational (download data)	signal transduction	44

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term signal transduction or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

signal transduction      70 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
PDE2/YOR360C	IEA: Inferred from Electronic Annotation with EBI:IPR002073 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PKC1/YBL105C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Levin DE, et al.  (1994) Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae. Cell Mol Biol Res 40(3):229-39	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR011072 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PLC1/YPL268W	IEA: Inferred from Electronic Annotation with EBI:IPR001711 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0807 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
PSK1/YAL017W	IEA: Inferred from Electronic Annotation with EBI:IPR000014 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PSK2/YOL045W	IEA: Inferred from Electronic Annotation with EBI:IPR000014 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RAS1/YOR101W	IEA: Inferred from Electronic Annotation with EBI:IPR020849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RAS2/YNL098C	IEA: Inferred from Electronic Annotation with EBI:IPR020849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RDS2/YPL133C	IEA: Inferred from Electronic Annotation with EBI:IPR000014 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RGA1/YOR127W	IEA: Inferred from Electronic Annotation with EBI:IPR008936, EBI:IPR000198 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RGA2/YDR379W	IEA: Inferred from Electronic Annotation with EBI:IPR008936, EBI:IPR000198 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RGD1/YBR260C	IEA: Inferred from Electronic Annotation with EBI:IPR008936, EBI:IPR000198 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RGD2/YFL047W	IEA: Inferred from Electronic Annotation with EBI:IPR008936, EBI:IPR000198 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RGT2/YDL138W	TAS: Traceable Author Statement Assigned on 2002-12-04	manually curated	Ozcan S and Johnston M  (1999) Function and regulation of yeast hexose transporters. Microbiol Mol Biol Rev 63(3):554-69	SGD
RHB1/YCR027C	IEA: Inferred from Electronic Annotation with EBI:IPR020849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RLM1/YPL089C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Watanabe Y, et al.  (1995) Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol 15(10):5740-9	SGD
RSR1/YGR152C	IEA: Inferred from Electronic Annotation with EBI:IPR020849 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RTS1/YOR014W	IEA: Inferred from Electronic Annotation with EBI:IPR002554 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SAC7/YDR389W	IEA: Inferred from Electronic Annotation with EBI:IPR008936, EBI:IPR000198 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SIP1/YDR422C	IGI: Inferred from Genetic Interaction with SGD:SIP2, SGD:GAL83 Assigned on 2007-03-08	manually curated	Schmidt MC and McCartney RR  (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43	SGD
SIP2/YGL208W	IGI: Inferred from Genetic Interaction with SGD:SIP1, SGD:GAL83 Assigned on 2007-03-08	manually curated	Schmidt MC and McCartney RR  (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43	SGD
SLM4/YBR077C	IMP: Inferred from Mutant Phenotype Assigned on 2005-02-28	manually curated	Huang J, et al.  (2004) Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc Natl Acad Sci U S A 101(47):16594-9	SGD
SLN1/YIL147C	IEA: Inferred from Electronic Annotation with EBI:IPR009082, EBI:IPR003661 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SLT2/YHR030C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Lee KS, et al.  (1993) A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. Mol Cell Biol 13(5):3067-75	SGD
SNF1/YDR477W	TAS: Traceable Author Statement Assigned on 2002-12-02	manually curated	Carlson M  (1999) Glucose repression in yeast. Curr Opin Microbiol 2(2):202-7	SGD
SNF3/YDL194W	TAS: Traceable Author Statement Assigned on 2002-12-04	manually curated	Ozcan S and Johnston M  (1999) Function and regulation of yeast hexose transporters. Microbiol Mol Biol Rev 63(3):554-69	SGD
SOG2/YOR353C	IMP: Inferred from Mutant Phenotype Assigned on 2006-09-15	manually curated	Nelson B, et al.  (2003) RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell 14(9):3782-803	SGD
SST2/YLR452C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Apanovitch DM, et al.  (1998) Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-Galpha protein pair in yeast. Biochemistry 37(14):4815-22	SGD
STD1/YOR047C	IMP: Inferred from Mutant Phenotype Assigned on 2002-07-16	manually curated	Schmidt MC, et al.  (1999) Std1 and Mth1 proteins interact with the glucose sensors to control glucose-regulated gene expression in Saccharomyces cerevisiae. Mol Cell Biol 19(7):4561-71	SGD
STE18/YJR086W	IEA: Inferred from Electronic Annotation with EBI:KW-0807 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
STE2/YFL026W	IEA: Inferred from Electronic Annotation with EBI:KW-0807 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

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