GO term: signal transduction 
Ontology: Biological Process (GO:0007165)
Definition: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Synonyms: signaling cascade; signalling cascade; signalling pathway; signaling pathway
View Ontology:
(graph) | 
(text)
Definition: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Synonyms: signaling cascade; signalling cascade; signalling pathway; signaling pathway
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
signal transduction (70 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | signal transduction | 30 |
| High-throughput | none | none |
| Computational (download data) | signal transduction | 44 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
signal transduction or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| signal transduction 70 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| BAG7/YOR134W | IEA: Inferred from Electronic Annotation with EBI:IPR000198, EBI:IPR008936 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| BCY1/YIL033C | IEA: Inferred from Electronic Annotation with EBI:IPR003117 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| BEM2/YER155C | IEA: Inferred from Electronic Annotation with EBI:IPR008936, EBI:IPR000198 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| BEM3/YPL115C | IEA: Inferred from Electronic Annotation with EBI:IPR008936, EBI:IPR000198 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| BUD2/YKL092C | IEA: Inferred from Electronic Annotation with EBI:IPR008936 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| CDC55/YGL190C | IEA: Inferred from Electronic Annotation with EBI:IPR000009 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| CMK1/YFR014C | IMP: Inferred from Mutant Phenotype Assigned on 2002-11-22 |
manually curated | Souza AC, et al. (2002) Evidence for a modulation of neutral trehalase activity by Ca2+ and cAMP signaling pathways in Saccharomyces cerevisiae. Braz J Med Biol Res 35(1):11-6 |
SGD |
| CMK2/YOL016C | NAS: Non-traceable Author Statement Assigned on 2001-01-18 |
manually curated | Ohya Y, et al. (1991) Two yeast genes encoding calmodulin-dependent protein kinases. Isolation, sequencing and bacterial expressions of CMK1 and CMK2. J Biol Chem 266(19):12784-94 |
SGD |
| COS111/YBR203W | IMP: Inferred from Mutant Phenotype Assigned on 2003-04-10 |
manually curated | Leem SH, et al. (2003) The possible mechanism of action of ciclopirox olamine in the yeast Saccharomyces cerevisiae. Mol Cells 15(1):55-61 |
SGD |
| CYR1/YJL005W | IEA: Inferred from Electronic Annotation with EBI:IPR000159 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| DPP1/YDR284C | TAS: Traceable Author Statement Assigned on 2003-12-03 |
manually curated | Toke DA, et al. (1999) Mutagenesis of the phosphatase sequence motif in diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae. Biochemistry 38(44):14606-13 |
SGD |
| ECM25/YJL201W | IEA: Inferred from Electronic Annotation with EBI:IPR008936, EBI:IPR000198 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| ERT1/YBR239C | IEA: Inferred from Electronic Annotation with EBI:IPR000014 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| GAL83/YER027C | IGI: Inferred from Genetic Interaction with SGD:SIP1, SGD:SIP2 Assigned on 2007-03-08 |
manually curated | Schmidt MC and McCartney RR (2000) beta-subunits of Snf1 kinase are required for kinase function and substrate definition. EMBO J 19(18):4936-43 |
SGD |
| GPA1/YHR005C | IEA: Inferred from Electronic Annotation with EBI:IPR011025 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0807 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GPA2/YER020W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Donzeau M and Bandlow W (1999) The yeast trimeric guanine nucleotide-binding protein alpha subunit, Gpa2p, controls the meiosis-specific kinase Ime2p activity in response to nutrients. Mol Cell Biol 19(9):6110-9 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR011025 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0807 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GPB1/YOR371C | IPI: Inferred from Physical Interaction Assigned on 2002-09-03 |
manually curated | Harashima T and Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10(1):163-73 |
SGD |
| GPB2/YAL056W | IPI: Inferred from Physical Interaction Assigned on 2002-09-03 |
manually curated | Harashima T and Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10(1):163-73 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0807 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GPG1/YGL121C | IPI: Inferred from Physical Interaction Assigned on 2002-09-03 |
manually curated | Harashima T and Heitman J (2002) The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits. Mol Cell 10(1):163-73 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0807 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GPR1/YDL035C | IEA: Inferred from Electronic Annotation with EBI:KW-0807 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| GSP1/YLR293C | IEA: Inferred from Electronic Annotation with EBI:IPR002041 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| GSP2/YOR185C | IEA: Inferred from Electronic Annotation with EBI:IPR002041 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IQG1/YPL242C | IEA: Inferred from Electronic Annotation with EBI:IPR008936 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IRA1/YBR140C | IEA: Inferred from Electronic Annotation with EBI:IPR008936 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IRA2/YOL081W | IEA: Inferred from Electronic Annotation with EBI:IPR008936 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| LRG1/YDL240W | IEA: Inferred from Electronic Annotation with EBI:IPR008936, EBI:IPR000198 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| LST8/YNL006W | IMP: Inferred from Mutant Phenotype Assigned on 2003-05-07 |
manually curated | Chen EJ and Kaiser CA (2003) LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J Cell Biol 161(2):333-47 |
SGD |
| MKK1/YOR231W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Irie K, et al. (1993) MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Mol Cell Biol 13(5):3076-83 |
SGD |
| MKK2/YPL140C | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Irie K, et al. (1993) MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Mol Cell Biol 13(5):3076-83 |
SGD |
| MTH1/YDR277C | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-10-03 |
manually curated | Schulte F, et al. (2000) The HTR1 gene is a dominant negative mutant allele of MTH1 and blocks Snf3- and Rgt2-dependent glucose signaling in yeast. J Bacteriol 182(2):540-2 |
SGD |
