Ontology: Biological Process (GO:0070987)

Definition: The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term error-free translesion synthesis (9 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	error-free translesion synthesis	9
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term error-free translesion synthesis or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

error-free translesion synthesis      9 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CSM2/YIL132C	IC: Inferred By Curator from Shu complex Assigned on 2011-12-06	manually curated	Ball LG, et al.  (2009) The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol 73(1):89-102	SGD
PSY3/YLR376C	IGI: Inferred from Genetic Interaction with SGD:REV3 Assigned on 2011-12-06	manually curated	Ball LG, et al.  (2009) The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol 73(1):89-102	SGD
RAD18/YCR066W	IGI: Inferred from Genetic Interaction with SGD:RAD30 Assigned on 2009-11-11	manually curated	McDonald JP, et al.  (1997) The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism. Genetics 147(4):1557-68	SGD
RAD30/YDR419W	IDA: Inferred from Direct Assay Assigned on 2010-01-19	manually curated	Haracska L, et al.  (2000) Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta. Nat Genet 25(4):458-61	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-01-19	manually curated	Yuan F, et al.  (2000) Specificity of DNA lesion bypass by the yeast DNA polymerase eta. J Biol Chem 275(11):8233-9	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-01-19	manually curated	Haracska L, et al.  (2000) Replication past O(6)-methylguanine by yeast and human DNA polymerase eta. Mol Cell Biol 20(21):8001-7	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-01-19	manually curated	Johnson RE, et al.  (1999) Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta. Science 283(5404):1001-4	SGD
RAD6/YGL058W	IGI: Inferred from Genetic Interaction with SGD:RAD30 Assigned on 2009-11-11	manually curated	McDonald JP, et al.  (1997) The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism. Genetics 147(4):1557-68	SGD
REV1/YOR346W	IDA: Inferred from Direct Assay Assigned on 2010-02-02	manually curated	Nelson JR, et al.  (1996) Deoxycytidyl transferase activity of yeast REV1 protein. Nature 382(6593):729-31	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2010-02-02	manually curated	Baynton K, et al.  (1999) Distinct roles for Rev1p and Rev7p during translesion synthesis in Saccharomyces cerevisiae. Mol Microbiol 34(1):124-33	SGD
REV3/YPL167C	IDA: Inferred from Direct Assay Assigned on 2010-02-02	manually curated	Johnson RE, et al.  (2003) Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycol. Genes Dev 17(1):77-87	SGD
REV7/YIL139C	IDA: Inferred from Direct Assay Assigned on 2010-02-02	manually curated	Johnson RE, et al.  (2003) Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycol. Genes Dev 17(1):77-87	SGD
SHU2/YDR078C	IC: Inferred By Curator from Shu complex Assigned on 2011-12-06	manually curated	Ball LG, et al.  (2009) The yeast Shu complex couples error-free post-replication repair to homologous recombination. Mol Microbiol 73(1):89-102	SGD

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