GO term: chromosome segregation 
Ontology: Biological Process (GO:0007059)
Definition: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
Synonyms: chromosome division; chromosome transmission
View Ontology:
(graph) | 
(text)
Definition: The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
Synonyms: chromosome division; chromosome transmission
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
chromosome segregation (69 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | chromosome segregation | 44 |
| High-throughput | none | none |
| Computational (download data) | chromosome segregation | 28 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
chromosome segregation or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| chromosome segregation 69 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AFT1/YGL071W | IMP: Inferred from Mutant Phenotype Assigned on 2013-04-23 |
manually curated | Measday V, et al. (2005) Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation. Proc Natl Acad Sci U S A 102(39):13956-61 |
SGD |
| ASK1/YKL052C | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| ATG31/YDR022C | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| BIR1/YJR089W | IMP: Inferred from Mutant Phenotype Assigned on 2002-10-09 |
manually curated | Yoon HJ and Carbon J (1999) Participation of Bir1p, a member of the inhibitor of apoptosis family, in yeast chromosome segregation events. Proc Natl Acad Sci U S A 96(23):13208-13 |
SGD |
| CBF1/YJR060W | IMP: Inferred from Mutant Phenotype Assigned on 2011-08-22 |
manually curated | Baker RE and Masison DC (1990) Isolation of the gene encoding the Saccharomyces cerevisiae centromere-binding protein CP1. Mol Cell Biol 10(6):2458-67 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2011-08-22 |
manually curated | Mellor J, et al. (1991) DNA binding of CPF1 is required for optimal centromere function but not for maintaining methionine prototrophy in yeast. Nucleic Acids Res 19(11):2961-9 |
SGD | |
| IGI: Inferred from Genetic Interaction with SGD:CSE4, SGD:CBF2, SGD:CEP3 Assigned on 2011-08-22 |
manually curated | Baker RE, et al. (1998) Mutations synthetically lethal with cep1 target S. cerevisiae kinetochore components. Genetics 149(1):73-85 |
SGD | |
| IMP: Inferred from Mutant Phenotype Assigned on 2006-01-30 |
manually curated | Cai M and Davis RW (1990) Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy. Cell 61(3):437-46 |
SGD | |
| CBF2/YGR140W | IMP: Inferred from Mutant Phenotype Assigned on 2003-01-10 |
manually curated | Goh PY and Kilmartin JV (1993) NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae. J Cell Biol 121(3):503-12 |
SGD |
| CHL1/YPL008W | IDA: Inferred from Direct Assay Assigned on 2002-09-04 |
manually curated | L Holloway S (2000) CHL1 is a nuclear protein with an essential ATP binding site that exhibits a size-dependent effect on chromosome segregation. Nucleic Acids Res 28(16):3056-64 |
SGD |
| CHL4/YDR254W | IMP: Inferred from Mutant Phenotype Assigned on 2002-09-27 |
manually curated | Roy N, et al. (1997) The mcm17 mutation of yeast shows a size-dependent segregational defect of a mini-chromosome. Curr Genet 32(3):182-9 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2002-09-27 |
manually curated | Kouprina N, et al. (1993) Identification and cloning of the CHL4 gene controlling chromosome segregation in yeast. Genetics 135(2):327-41 |
SGD | |
| CIA2/YHR122W | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| CNN1/YFR046C | IPI: Inferred from Physical Interaction with SGD:SPC24 Assigned on 2005-05-02 |
manually curated | Cho RJ, et al. (1998) Parallel analysis of genetic selections using whole genome oligonucleotide arrays. Proc Natl Acad Sci U S A 95(7):3752-7 |
SGD |
| IPI: Inferred from Physical Interaction with SGD:NNF1 Assigned on 2005-05-02 |
manually curated | De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21 |
SGD | |
| CSM4/YPL200W | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| CTF19/YPL018W | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-06-17 |
manually curated | Hyland KM, et al. (1999) Ctf19p: A novel kinetochore protein in Saccharomyces cerevisiae and a potential link between the kinetochore and mitotic spindle. J Cell Biol 145(1):15-28 |
SGD |
| CTF3/YLR381W | IPI: Inferred from Physical Interaction Assigned on 2002-09-05 |
manually curated | Measday V, et al. (2002) Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore. Genes Dev 16(1):101-13 |
SGD |
| DAD1/YDR016C | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| DAD2/YKR083C | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| DAD3/YBR233W-A | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| DAD4/YDR320C-A | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| DAM1/YGR113W | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| DBF4/YDR052C | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| DSN1/YIR010W | IDA: Inferred from Direct Assay Assigned on 2002-12-09 |
manually curated | Euskirchen GM (2002) Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell 1(2):229-40 |
SGD |
| DUO1/YGL061C | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| ESP1/YGR098C | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| GIP3/YPL137C | IMP: Inferred from Mutant Phenotype Assigned on 2006-06-30 |
manually curated | Pinsky BA, et al. (2006) Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Mol Cell Biol 26(7):2648-60 |
SGD |
| GIP4/YAL031C | IMP: Inferred from Mutant Phenotype Assigned on 2006-06-30 |
manually curated | Pinsky BA, et al. (2006) Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Mol Cell Biol 26(7):2648-60 |
SGD |
| GLC7/YER133W | IMP: Inferred from Mutant Phenotype Assigned on 2005-11-01 |
manually curated | Sassoon I, et al. (1999) Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. Genes Dev 13(5):545-55 |
SGD |
| GLC8/YMR311C | IMP: Inferred from Mutant Phenotype Assigned on 2005-09-20 |
manually curated | Tung HY, et al. (1995) Regulation of chromosome segregation by Glc8p, a structural homolog of mammalian inhibitor 2 that functions as both an activator and an inhibitor of yeast protein phosphatase 1. Mol Cell Biol 15(11):6064-74 |
SGD |
| HDA3/YPR179C | IMP: Inferred from Mutant Phenotype Assigned on 2009-05-15 |
manually curated | Kanta H, et al. (2006) Suppressor analysis of a histone defect identifies a new function for the hda1 complex in chromosome segregation. Genetics 173(1):435-50 |
SGD |
| HSK3/YKL138C-A | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IPL1/YPL209C | IMP: Inferred from Mutant Phenotype Assigned on 2006-06-30 |
manually curated | Chan CS and Botstein D (1993) Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics 135(3):677-91 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IRR1/YIL026C | IEA: Inferred from Electronic Annotation with EBI:KW-0159 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
