Ontology: Biological Process (GO:0070525)

Definition: The chemical reactions and pathways involving threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.

Synonyms: t6A metabolic process; t6A metabolism; threonylcarbamoyladenosine metabolism

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term threonylcarbamoyladenosine metabolic process (4 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	threonylcarbamoyladenosine metabolic process	4
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term threonylcarbamoyladenosine metabolic process or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

threonylcarbamoyladenosine metabolic process      4 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
BUD32/YGR262C	IMP: Inferred from Mutant Phenotype Assigned on 2011-02-14	manually curated	Srinivasan M, et al.  (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30(5):873-81	SGD
KAE1/YKR038C	IMP: Inferred from Mutant Phenotype Assigned on 2011-02-14	manually curated	Srinivasan M, et al.  (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30(5):873-81	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-11-17	manually curated	Daugeron MC, et al.  (2011) Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. Nucleic Acids Res 39(14):6148-60	SGD
PCC1/YKR095W-A	IMP: Inferred from Mutant Phenotype Assigned on 2011-02-14	manually curated	Srinivasan M, et al.  (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30(5):873-81	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-11-17	manually curated	Daugeron MC, et al.  (2011) Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. Nucleic Acids Res 39(14):6148-60	SGD
SUA5/YGL169W	IMP: Inferred from Mutant Phenotype Assigned on 2011-02-14	manually curated	El Yacoubi B, et al.  (2009) The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA. Nucleic Acids Res 37(9):2894-909	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-02-14	manually curated	Srinivasan M, et al.  (2011) The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. EMBO J 30(5):873-81	SGD

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