Ontology: Biological Process (GO:0007015)

Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.

Synonyms: actin filament organisation; regulation of actin filament localization

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term actin filament organization (37 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	actin filament organization	37
High-throughput	none	none
Computational (download data)	actin filament organization	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term actin filament organization or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

actin filament organization      37 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ARC18/YLR370C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Winter DC, et al.  (1999) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A 96(13):7288-93	SGD
ARC40/YBR234C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Winter DC, et al.  (1999) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A 96(13):7288-93	SGD
ARK1/YNL020C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Cope MJ, et al.  (1999) Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. J Cell Biol 144(6):1203-18	SGD
ARP2/YDL029W	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Winter DC, et al.  (1999) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A 96(13):7288-93	SGD
ARP3/YJR065C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Winter DC, et al.  (1999) Genetic dissection of the budding yeast Arp2/3 complex: a comparison of the in vivo and structural roles of individual subunits. Proc Natl Acad Sci U S A 96(13):7288-93	SGD
BZZ1/YHR114W	IPI: Inferred from Physical Interaction with SGD:LAS17 Assigned on 2002-12-18	manually curated	Soulard A, et al.  (2002) Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. Mol Cell Biol 22(22):7889-906	SGD
CRN1/YLR429W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Goode BL, et al.  (1999) Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast. J Cell Biol 144(1):83-98	SGD
END3/YNL084C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR025604 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ENT1/YDL161W	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Wendland B, et al.  (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93	SGD
ENT2/YLR206W	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Wendland B, et al.  (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93	SGD
ENT3/YJR125C	ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Wendland B, et al.  (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93	SGD
ENT4/YLL038C	ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Wendland B, et al.  (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93	SGD
IQG1/YPL242C	IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Shannon KB and Li R  (1999) The multiple roles of Cyk1p in the assembly and function of the actomyosin ring in budding yeast. Mol Biol Cell 10(2):283-96	SGD
LAS17/YOR181W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Lechler T and Li R  (1997) In vitro reconstitution of cortical actin assembly sites in budding yeast. J Cell Biol 138(1):95-103	SGD
LSB5/YCL034W	IPI: Inferred from Physical Interaction Assigned on 2002-10-11	manually curated	Madania A, et al.  (1999) The Saccharomyces cerevisiae homologue of human Wiskott-Aldrich syndrome protein Las17p interacts with the Arp2/3 complex. Mol Biol Cell 10(10):3521-38	SGD
MSB3/YNL293W	IGI: Inferred from Genetic Interaction with SGD:MSB4, IPI: Inferred from Physical Interaction with SGD:CDC42, SGD:RHO1 Assigned on 2009-06-11	manually curated	Tcheperegine SE, et al.  (2005) Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components. Mol Cell Biol 25(19):8567-80	SGD
MSB4/YOL112W	IGI: Inferred from Genetic Interaction with SGD:MSB3, IPI: Inferred from Physical Interaction with SGD:CDC42, SGD:RHO1 Assigned on 2009-06-11	manually curated	Tcheperegine SE, et al.  (2005) Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components. Mol Cell Biol 25(19):8567-80	SGD
PBS2/YJL128C	IMP: Inferred from Mutant Phenotype Assigned on 2003-01-16	manually curated	Brewster JL and Gustin MC  (1994) Positioning of cell growth and division after osmotic stress requires a MAP kinase pathway. Yeast 10(4):425-39	SGD
PEA2/YER149C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states. J Cell Sci 113 ( Pt 3):365-75	SGD
PKC1/YBL105C	IGI: Inferred from Genetic Interaction Assigned on 2003-08-21	manually curated	Dong Y, et al.  (2003) Formin-dependent actin assembly is regulated by distinct modes of Rho signaling in yeast. J Cell Biol 161(6):1081-92	SGD
PPH21/YDL134C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Wang Y and Burke DJ  (1997) Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol Cell Biol 17(2):620-6	SGD
PPH22/YDL188C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Wang Y and Burke DJ  (1997) Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol Cell Biol 17(2):620-6	SGD
PRK1/YIL095W	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Zeng G and Cai M  (1999) Regulation of the actin cytoskeleton organization in yeast by a novel serine/threonine kinase Prk1p. J Cell Biol 144(1):71-82	SGD
RDI1/YDL135C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2003-01-16	manually curated	Koch G, et al.  (1997) Association of the Rho family small GTP-binding proteins with Rho GDP dissociation inhibitor (Rho GDI) in Saccharomyces cerevisiae. Oncogene 15(4):417-22	SGD
RGA1/YOR127W	IMP: Inferred from Mutant Phenotype Assigned on 2003-01-16	manually curated	Chen GC, et al.  (1996) The LIM domain-containing Dbm1 GTPase-activating protein is required for normal cellular morphogenesis in Saccharomyces cerevisiae. Mol Cell Biol 16(4):1376-90	SGD
RGA2/YDR379W	ISS: Inferred from Sequence or structural Similarity Assigned on 2003-01-16	manually curated	Stevenson BJ, et al.  (1995) Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae. Genes Dev 9(23):2949-63	SGD
RHO2/YNL090W	TAS: Traceable Author Statement Assigned on 2003-01-16	manually curated	Madden K and Snyder M  (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD
SAC6/YDR129C	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2003-08-27	manually curated	Karpova TS, et al.  (1995) Actin filaments in yeast are unstable in the absence of capping protein or fimbrin. J Cell Biol 131(6 Pt 1):1483-93	SGD
SCD5/YOR329C	IMP: Inferred from Mutant Phenotype Assigned on 2009-08-28	manually curated	Chang JS, et al.  (2002) Protein phosphatase-1 binding to scd5p is important for regulation of actin organization and endocytosis in yeast. J Biol Chem 277(50):48002-8	SGD
SCP1/YOR367W	IDA: Inferred from Direct Assay Assigned on 2003-08-28	manually curated	Goodman A, et al.  (2003) The Saccharomyces cerevisiae calponin/transgelin homolog Scp1 functions with fimbrin to regulate stability and organization of the actin cytoskeleton. Mol Biol Cell 14(7):2617-29	SGD

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