Ontology: Biological Process (GO:0070096)

Definition: The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex.

Synonyms: TOM complex assembly

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term mitochondrial outer membrane translocase complex assembly (8 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	mitochondrial outer membrane translocase complex assembly	8
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term mitochondrial outer membrane translocase complex assembly or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

mitochondrial outer membrane translocase complex assembly      8 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
MDM10/YAL010C	IMP: Inferred from Mutant Phenotype Assigned on 2011-02-02	manually curated	Meisinger C, et al.  (2004) The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell 7(1):61-71	SGD
	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:TOM22 Assigned on 2011-12-02	manually curated	Thornton N, et al.  (2010) Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of alpha-helical outer membrane proteins. J Mol Biol 396(3):540-9	SGD
MIM1/YOL026C	IMP: Inferred from Mutant Phenotype Assigned on 2011-03-31	manually curated	Waizenegger T, et al.  (2005) Mim1, a protein required for the assembly of the TOM complex of mitochondria. EMBO Rep 6(1):57-62	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-04-01	manually curated	Becker T, et al.  (2008) Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J Biol Chem 283(1):120-7	SGD
MIM2/YLR099W-A	IGI: Inferred from Genetic Interaction with SGD:MIM1, IPI: Inferred from Physical Interaction with SGD:MIM1 Assigned on 2012-05-03	manually curated	Dimmer KS, et al.  (2012) A crucial role for Mim2 in the biogenesis of mitochondrial outer membrane proteins. J Cell Sci 125(Pt 14):3464-73	SGD
SAM35/YHR083W	IMP: Inferred from Mutant Phenotype Assigned on 2009-04-09	manually curated	Milenkovic D, et al.  (2004) Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. J Biol Chem 279(21):22781-5	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2009-04-09	manually curated	Waizenegger T, et al.  (2004) Tob38, a novel essential component in the biogenesis of beta-barrel proteins of mitochondria. EMBO Rep 5(7):704-9	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2009-04-09	manually curated	Stojanovski D, et al.  (2007) Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins. J Cell Biol 179(5):881-93	SGD
SAM37/YMR060C	IMP: Inferred from Mutant Phenotype Assigned on 2009-04-10	manually curated	Wiedemann N, et al.  (2003) Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424(6948):565-71	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2009-04-10	manually curated	Stojanovski D, et al.  (2007) Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins. J Cell Biol 179(5):881-93	SGD
TOM20/YGR082W	IMP: Inferred from Mutant Phenotype Assigned on 2009-07-30	manually curated	Model K, et al.  (2002) Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex. J Mol Biol 316(3):657-66	SGD
TOM5/YPR133W-A	IDA: Inferred from Direct Assay Assigned on 2011-04-04	manually curated	Becker T, et al.  (2010) Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex. Mol Biol Cell 21(18):3106-13	SGD
TOM6/YOR045W	IDA: Inferred from Direct Assay Assigned on 2011-04-04	manually curated	Becker T, et al.  (2010) Assembly of the mitochondrial protein import channel: role of Tom5 in two-stage interaction of Tom40 with the SAM complex. Mol Biol Cell 21(18):3106-13	SGD

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