Ontology: Biological Process (GO:0007004)

Definition: The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.

Synonyms: telomerase-dependent telomere maintenance

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term telomere maintenance via telomerase (14 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	telomere maintenance via telomerase	14
High-throughput	none	none
Computational (download data)	telomere maintenance via telomerase	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term telomere maintenance via telomerase or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

telomere maintenance via telomerase      14 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CDC13/YDL220C	IGI: Inferred from Genetic Interaction with SGD:STN1, SGD:EST1 Assigned on 2007-06-27	manually curated	Pennock E, et al.  (2001) Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104(3):387-96	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-18	manually curated	Lendvay TS, et al.  (1996) Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144(4):1399-412	SGD
EST1/YLR233C	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-18	manually curated	Lendvay TS, et al.  (1996) Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144(4):1399-412	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2008-09-18	manually curated	Hughes TR, et al.  (2000) The Est3 protein is a subunit of yeast telomerase. Curr Biol 10(13):809-12	SGD
EST2/YLR318W	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-18	manually curated	Lendvay TS, et al.  (1996) Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144(4):1399-412	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2005-04-21	manually curated	Liao XH, et al.  (2005) Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. Biochem J 390(Pt 1):169-76	SGD
EST3/YIL009C-A	IMP: Inferred from Mutant Phenotype Assigned on 2007-01-19	manually curated	Morris DK and Lundblad V  (1997) Programmed translational frameshifting in a gene required for yeast telomere replication. Curr Biol 7(12):969-76	UniProtKB
	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-18	manually curated	Lendvay TS, et al.  (1996) Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144(4):1399-412	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR019437 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HEK2/YBL032W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-10-09	manually curated	Denisenko O and Bomsztyk K  (2002) Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length. Mol Cell Biol 22(1):286-97	SGD
LCD1/YDR499W	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-08	manually curated	Enomoto S, et al.  (2002) MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae. Mol Biol Cell 13(8):2626-38	SGD
RFA1/YAR007C	IPI: Inferred from Physical Interaction with SGD:RFA2 Assigned on 2007-09-18	manually curated	Brill SJ and Stillman B  (1989) Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replication. Nature 342(6245):92-5	SGD
RFA2/YNL312W	IMP: Inferred from Mutant Phenotype Assigned on 2007-09-18	manually curated	Schramke V, et al.  (2004) RPA regulates telomerase action by providing Est1p access to chromosome ends. Nat Genet 36(1):46-54	SGD
RFA3/YJL173C	IPI: Inferred from Physical Interaction with SGD:RFA2 Assigned on 2007-09-18	manually curated	Brill SJ and Stillman B  (1989) Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replication. Nature 342(6245):92-5	SGD
RIF2/YLR453C	IMP: Inferred from Mutant Phenotype Assigned on 2002-07-17	manually curated	Wotton D and Shore D  (1997) A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev 11(6):748-60	SGD
TEL2/YGR099W	IMP: Inferred from Mutant Phenotype Assigned on 2002-07-11	manually curated	Runge KW and Zakian VA  (1996) TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 16(6):3094-105	SGD
TEN1/YLR010C	IGI: Inferred from Genetic Interaction with SGD:TLC1, IMP: Inferred from Mutant Phenotype Assigned on 2007-10-29	manually curated	Grandin N, et al.  (2001) Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J 20(5):1173-83	SGD
TLC1	TAS: Traceable Author Statement Assigned on 2002-06-25	manually curated	Livengood AJ, et al.  (2002) Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol 22(7):2366-74	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2005-04-21	manually curated	Liao XH, et al.  (2005) Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. Biochem J 390(Pt 1):169-76	SGD
TOP3/YLR234W	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Kim RA, et al.  (1995) Effects of yeast DNA topoisomerase III on telomere structure. Proc Natl Acad Sci U S A 92(7):2667-71	SGD

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