GO term: mitotic sister chromatid segregation 
Ontology: Biological Process (GO:0000070)
Definition: The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
Synonyms: mitotic chromosome segregation; mitotic sister-chromatid adhesion release
Definition: The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
Synonyms: mitotic chromosome segregation; mitotic sister-chromatid adhesion release
This table lists the methods used to annotate genes either directly to the term
mitotic sister chromatid segregation (39 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | mitotic sister chromatid segregation | 38 |
| High-throughput | none | none |
| Computational (download data) | mitotic sister chromatid segregation | 1 |
Links to Additional Annotations:
Annotation details for genes that have been directly annotated to the term
mitotic sister chromatid segregation or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| mitotic sister chromatid segregation 39 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| APC1/YNL172W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| APC11/YDL008W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| APC2/YLR127C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| APC4/YDR118W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| APC5/YOR249C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| APC9/YLR102C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| BRN1/YBL097W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Ouspenski II, et al. (2000) Chromosome condensation factor Brn1p is required for chromatid separation in mitosis. Mol Biol Cell 11(4):1305-13 |
SGD |
| BUR2/YLR226W | IGI: Inferred from Genetic Interaction Assigned on 2001-01-18 |
manually curated | Ouspenski II, et al. (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8 |
SGD |
| CDC16/YKL022C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| CDC20/YGL116W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| CDC23/YHR166C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| CDC26/YFR036W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| CDC27/YBL084C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| CDH1/YGL003C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| CIK1/YMR198W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Manning BD, et al. (1999) Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. J Cell Biol 144(6):1219-33 |
SGD |
| CIN8/YEL061C | IGI: Inferred from Genetic Interaction with SGD:KIP1, SGD:DYN1 Assigned on 2008-10-08 |
manually curated | Saunders WS, et al. (1995) Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation. J Cell Biol 128(4):617-24 |
SGD |
| CSE2/YNR010W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Xiao Z, et al. (1993) CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Mol Cell Biol 13(8):4691-702 |
SGD |
| CSE4/YKL049C | IMP: Inferred from Mutant Phenotype Assigned on 2002-09-26 |
manually curated | Stoler S, et al. (1995) A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis. Genes Dev 9(5):573-86 |
SGD |
| DOC1/YGL240W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zachariae W and Nasmyth K (1999) Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13(16):2039-58 |
SGD |
| DYN1/YKR054C | IGI: Inferred from Genetic Interaction with SGD:CIN8, SGD:KIP1 Assigned on 2008-10-08 |
manually curated | Saunders WS, et al. (1995) Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation. J Cell Biol 128(4):617-24 |
SGD |
| ESP1/YGR098C | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-08-08 |
manually curated | Ciosk R, et al. (1998) An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93(6):1067-76 |
SGD |
| FIN1/YDR130C | IMP: Inferred from Mutant Phenotype Assigned on 2007-01-23 |
manually curated | Woodbury EL and Morgan DO (2007) Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol 9(1):106-12 |
SGD |
| KIP1/YBL063W | IGI: Inferred from Genetic Interaction with SGD:CIN8, SGD:DYN1 Assigned on 2008-10-08 |
manually curated | Saunders WS, et al. (1995) Saccharomyces cerevisiae kinesin- and dynein-related proteins required for anaphase chromosome segregation. J Cell Biol 128(4):617-24 |
SGD |
| MCK1/YNL307C | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Shero JH and Hieter P (1991) A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1). Genes Dev 5(4):549-60 |
SGD |
| MND2/YIR025W | IMP: Inferred from Mutant Phenotype Assigned on 2005-04-19 |
manually curated | Oelschlaegel T, et al. (2005) The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1. Cell 120(6):773-88 |
SGD |
| PDS1/YDR113C | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-08-08 |
manually curated | Ciosk R, et al. (1998) An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93(6):1067-76 |
SGD |
| SGO1/YOR073W | IMP: Inferred from Mutant Phenotype Assigned on 2004-02-09 |
manually curated | Kitajima TS, et al. (2004) The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis. Nature 427(6974):510-7 |
SGD |
| IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2005-02-25 |
manually curated | Indjeian VB, et al. (2005) The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes. Science 307(5706):130-3 |
SGD | |
| SGS1/YMR190C | IMP: Inferred from Mutant Phenotype Assigned on 2002-08-06 |
manually curated | Watt PM, et al. (1995) Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell 81(2):253-60 |
SGD |
| SMC1/YFL008W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Strunnikov AV, et al. (1993) SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family. J Cell Biol 123(6 Pt 2):1635-48 |
SGD |
| SMC2/YFR031C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Hirano T (1999) SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? Genes Dev 13(1):11-9 |
SGD |
This diagram shows the local area of the Gene Ontology and the numbers of yeast genes annotated to each term in the diagram. Within the diagram, click on the blue arrow to navigate up the tree and click on a GO term name to go to its GO term page.
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