Ontology: Biological Process (GO:0006897)

Definition: A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.

Synonyms: nonselective vesicle endocytosis; plasma membrane invagination; vesicle endocytosis

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term endocytosis (88 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	endocytosis	76
High-throughput	none	none
Computational (download data)	endocytosis	23

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term endocytosis or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

endocytosis      88 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
SLA2/YNL243W	IMP: Inferred from Mutant Phenotype Assigned on 2009-09-28	manually curated	Raths S, et al.  (1993) end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae. J Cell Biol 120(1):55-65	SGD
SLM6/YBR266C	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04	manually curated	Wiederkehr A, et al.  (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73	SGD
SNC1/YAL030W	IMP: Inferred from Mutant Phenotype Assigned on 2005-06-14	manually curated	Gurunathan S, et al.  (2000) Yeast exocytic v-SNAREs confer endocytosis. Mol Biol Cell 11(10):3629-43	SGD
SNC2/YOR327C	IGI: Inferred from Genetic Interaction with SGD:SNC1 Assigned on 2011-05-16	manually curated	Gurunathan S, et al.  (2000) Yeast exocytic v-SNAREs confer endocytosis. Mol Biol Cell 11(10):3629-43	SGD
SUR7/YML052W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2006-03-03	manually curated	Walther TC, et al.  (2006) Eisosomes mark static sites of endocytosis. Nature 439(7079):998-1003	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
SVL3/YPL032C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Zheng B, et al.  (1998) Isolation of yeast mutants defective for localization of vacuolar vital dyes. Proc Natl Acad Sci U S A 95(20):11721-6	SGD
SWH1/YAR042W	IGI: Inferred from Genetic Interaction with SGD:OSH2, SGD:OSH3, SGD:KES1, SGD:HES1, SGD:OSH6, SGD:OSH7 Assigned on 2006-10-20	manually curated	Beh CT and Rine J  (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96	SGD
SYP1/YCR030C	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
TLG1/YDR468C	IMP: Inferred from Mutant Phenotype Assigned on 2011-05-16	manually curated	Holthuis JC, et al.  (1998) Two syntaxin homologues in the TGN/endosomal system of yeast. EMBO J 17(1):113-26	SGD
TLG2/YOL018C	IMP: Inferred from Mutant Phenotype Assigned on 2011-05-16	manually curated	Holthuis JC, et al.  (1998) Two syntaxin homologues in the TGN/endosomal system of yeast. EMBO J 17(1):113-26	SGD
UBC1/YDR177W	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Hochstrasser M  (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39	SGD
VMA3/YEL027W	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Umemoto N, et al.  (1990) Roles of the VMA3 gene product, subunit c of the vacuolar membrane H(+)-ATPase on vacuolar acidification and protein transport. A study with VMA3-disrupted mutants of Saccharomyces cerevisiae. J Biol Chem 265(30):18447-53	SGD
VPS1/YKR001C	IGI: Inferred from Genetic Interaction with SGD:RVS167, IMP: Inferred from Mutant Phenotype Assigned on 2011-01-03	manually curated	Rooij II, et al.  (2010) A role for the dynamin-like protein Vps1 during endocytosis in yeast. J Cell Sci 123(Pt 20):3496-506	SGD
VPS21/YOR089C	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-13	manually curated	Singer-Kruger B, et al.  (1994) Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J Cell Biol 125(2):283-98	SGD
VPS33/YLR396C	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-19	manually curated	Subramanian S, et al.  (2004) The Sec1/Munc18 protein, Vps33p, functions at the endosome and the vacuole of Saccharomyces cerevisiae. Mol Biol Cell 15(6):2593-605	SGD
VRP1/YLR337C	IMP: Inferred from Mutant Phenotype Assigned on 2009-03-11	manually curated	Munn AL, et al.  (1995) end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 6(12):1721-42	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-08-10	manually curated	Naqvi SN, et al.  (1998) The WASp homologue Las17p functions with the WIP homologue End5p/verprolin and is essential for endocytosis in yeast. Curr Biol 8(17):959-62	SGD
WHI2/YOR043W	IMP: Inferred from Mutant Phenotype Assigned on 2004-07-12	manually curated	Care A, et al.  (2004) A synthetic lethal screen identifies a role for the cortical actin patch/endocytosis complex in the response to nutrient deprivation in Saccharomyces cerevisiae. Genetics 166(2):707-19	SGD
YAP1801/YHR161C	IPI: Inferred from Physical Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Wendland B and Emr SD  (1998) Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. J Cell Biol 141(1):71-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
YAP1802/YGR241C	IPI: Inferred from Physical Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Wendland B and Emr SD  (1998) Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. J Cell Biol 141(1):71-84	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
YCK1/YHR135C	IGI: Inferred from Genetic Interaction Assigned on 2003-01-31	manually curated	Robinson LC, et al.  (1999) The Yck2 yeast casein kinase 1 isoform shows cell cycle-specific localization to sites of polarized growth and is required for proper septin organization. Mol Biol Cell 10(4):1077-92	SGD
YCK2/YNL154C	IGI: Inferred from Genetic Interaction Assigned on 2003-01-31	manually curated	Robinson LC, et al.  (1999) The Yck2 yeast casein kinase 1 isoform shows cell cycle-specific localization to sites of polarized growth and is required for proper septin organization. Mol Biol Cell 10(4):1077-92	SGD
YOR223W	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
YPK1/YKL126W	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
YPP1/YGR198W	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
YPT52/YKR014C	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-13	manually curated	Singer-Kruger B, et al.  (1994) Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J Cell Biol 125(2):283-98	SGD
YPT53/YNL093W	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-13	manually curated	Singer-Kruger B, et al.  (1994) Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J Cell Biol 125(2):283-98	SGD
YPT7/YML001W	IMP: Inferred from Mutant Phenotype Assigned on 2006-08-17	manually curated	Wichmann H, et al.  (1992) Endocytosis in yeast: evidence for the involvement of a small GTP-binding protein (Ypt7p). Cell 71(7):1131-42	SGD
YSC84/YHR016C	IGI: Inferred from Genetic Interaction with SGD:LSB5 Assigned on 2009-09-25	manually curated	Dewar H, et al.  (2002) Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae. Mol Biol Cell 13(10):3646-61	SGD

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