Ontology: Biological Process (GO:0006897)

Definition: A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.

Synonyms: nonselective vesicle endocytosis; plasma membrane invagination; vesicle endocytosis

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term endocytosis (88 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	endocytosis	76
High-throughput	none	none
Computational (download data)	endocytosis	23

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term endocytosis or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

endocytosis      88 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
INP52/YNL106C	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
INP53/YOR109W	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
JJJ1/YNL227C	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04	manually curated	Wiederkehr A, et al.  (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73	SGD
KES1/YPL145C	IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH2, SGD:OSH3, SGD:HES1, SGD:OSH6, SGD:OSH7 Assigned on 2006-10-20	manually curated	Beh CT and Rine J  (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96	SGD
LDB17/YDL146W	IMP: Inferred from Mutant Phenotype Assigned on 2009-06-24	manually curated	Burston HE, et al.  (2009) Regulators of yeast endocytosis identified by systematic quantitative analysis. J Cell Biol 185(6):1097-110	SGD
LSB5/YCL034W	IGI: Inferred from Genetic Interaction with SGD:YSC84 Assigned on 2009-09-25	manually curated	Dewar H, et al.  (2002) Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae. Mol Biol Cell 13(10):3646-61	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
LSP1/YPL004C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2006-03-03	manually curated	Walther TC, et al.  (2006) Eisosomes mark static sites of endocytosis. Nature 439(7079):998-1003	SGD
MON2/YNL297C	IMP: Inferred from Mutant Phenotype Assigned on 2005-04-29	manually curated	Jochum A, et al.  (2002) Yeast Ysl2p, homologous to Sec7 domain guanine nucleotide exchange factors, functions in endocytosis and maintenance of vacuole integrity and interacts with the Arf-Like small GTPase Arl1p. Mol Cell Biol 22(13):4914-28	SGD
MSB3/YNL293W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:VPS21 Assigned on 2013-03-06	manually curated	Lachmann J, et al.  (2012) The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles. Mol Biol Cell 23(13):2516-26	SGD
MYO3/YKL129C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
MYO5/YMR109W	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
NEO1/YIL048W	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-02	manually curated	Wicky S, et al.  (2004) Molecular interactions of yeast Neo1p, an essential member of the Drs2 family of aminophospholipid translocases, and its role in membrane trafficking within the endomembrane system. Mol Cell Biol 24(17):7402-18	SGD
OSH2/YDL019C	IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH3, SGD:KES1, SGD:HES1, SGD:OSH6, SGD:OSH7 Assigned on 2006-10-20	manually curated	Beh CT and Rine J  (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96	SGD
OSH3/YHR073W	IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH2, SGD:KES1, SGD:HES1, SGD:OSH6, SGD:OSH7 Assigned on 2006-10-20	manually curated	Beh CT and Rine J  (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96	SGD
OSH6/YKR003W	IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH2, SGD:OSH3, SGD:KES1, SGD:HES1, SGD:OSH7 Assigned on 2006-10-20	manually curated	Beh CT and Rine J  (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96	SGD
OSH7/YHR001W	IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH2, SGD:OSH3, SGD:KES1, SGD:HES1, SGD:OSH6 Assigned on 2006-10-20	manually curated	Beh CT and Rine J  (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96	SGD
PAL1/YDR348C	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
PAN1/YIR006C	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-15	manually curated	Wendland B, et al.  (1996) A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J Cell Biol 135(6 Pt 1):1485-500	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR026812 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
PIL1/YGR086C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2006-03-03	manually curated	Walther TC, et al.  (2006) Eisosomes mark static sites of endocytosis. Nature 439(7079):998-1003	SGD
PKH1/YDR490C	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-08	manually curated	deHart AK, et al.  (2002) The conserved Pkh-Ypk kinase cascade is required for endocytosis in yeast. J Cell Biol 156(2):241-8	SGD
PKH2/YOL100W	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
RCY1/YJL204C	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04	manually curated	Wiederkehr A, et al.  (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04	manually curated	Wiederkehr A, et al.  (2000) The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling out of an early endosome in Saccharomyces cerevisiae. J Cell Biol 149(2):397-410	SGD
ROY1/YMR258C	IGI: Inferred from Genetic Interaction with SGD:VPS21 Assigned on 2011-03-21	manually curated	Liu Y, et al.  (2011) Non-SCF-type F-box protein Roy1/Ymr258c interacts with a Rab5-like GTPase Ypt52 and inhibits Ypt52 function. Mol Biol Cell 22(9):1575-84	SGD
RVS161/YCR009C	IMP: Inferred from Mutant Phenotype Assigned on 2009-03-11	manually curated	Munn AL, et al.  (1995) end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 6(12):1721-42	SGD
RVS167/YDR388W	IMP: Inferred from Mutant Phenotype Assigned on 2009-03-11	manually curated	Munn AL, et al.  (1995) end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 6(12):1721-42	SGD
SAC6/YDR129C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
SCD5/YOR329C	IMP: Inferred from Mutant Phenotype Assigned on 2009-08-28	manually curated	Chang JS, et al.  (2006) Cortical recruitment and nuclear-cytoplasmic shuttling of Scd5p, a protein phosphatase-1-targeting protein involved in actin organization and endocytosis. Mol Biol Cell 17(1):251-62	SGD
SDS24/YBR214W	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04	manually curated	Wiederkehr A, et al.  (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73	SGD
SIW14/YNL032W	IMP: Inferred from Mutant Phenotype Assigned on 2004-07-12	manually curated	Care A, et al.  (2004) A synthetic lethal screen identifies a role for the cortical actin patch/endocytosis complex in the response to nutrient deprivation in Saccharomyces cerevisiae. Genetics 166(2):707-19	SGD
SLA1/YBL007C	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2003-02-07	manually curated	Howard JP, et al.  (2002) Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis. J Cell Biol 157(2):315-26	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

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