GO term: endocytosis 
Ontology: Biological Process (GO:0006897)
Definition: A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle.
Synonyms: nonselective vesicle endocytosis; plasma membrane invagination; vesicle endocytosis
Definition: A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle.
Synonyms: nonselective vesicle endocytosis; plasma membrane invagination; vesicle endocytosis
This table lists the methods used to annotate genes either directly to the term
endocytosis (80 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | endocytosis | 73 |
| High-throughput | none | none |
| Computational (download data) | endocytosis | 18 |
Links to Additional Annotations:
Annotation details for genes that have been directly annotated to the term
endocytosis or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| endocytosis 80 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ACT1/YFL039C | IMP: Inferred from Mutant Phenotype Assigned on 2009-03-11 |
manually curated | Munn AL, et al. (1995) end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 6(12):1721-42 |
SGD |
| AKR1/YDR264C | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Givan SA and Sprague GF Jr (1997) The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors. Mol Biol Cell 8(7):1317-27 |
SGD |
| AKR2/YOR034C | ISS: Inferred from Sequence or structural Similarity Assigned on 2005-05-10 |
manually curated | Givan SA and Sprague GF Jr (1997) The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors. Mol Biol Cell 8(7):1317-27 |
SGD |
| ARF3/YOR094W | IGI: Inferred from Genetic Interaction with SGD:SLA1, IMP: Inferred from Mutant Phenotype Assigned on 2010-01-12 |
manually curated | Smaczynska-de Rooij II, et al. (2008) Yeast Arf3p Modulates Plasma Membrane PtdIns(4,5)P2 Levels to Facilitate Endocytosis. Traffic 9(4):559-73 |
SGD |
| ART5/YGR068C | IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| BRE4/YDL231C | IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04 |
manually curated | Wiederkehr A, et al. (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73 |
SGD |
| BSP1/YPR171W | IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| BZZ1/YHR114W | IGI: Inferred from Genetic Interaction with SGD:MYO5 Assigned on 2006-10-25 |
manually curated | Soulard A, et al. (2005) The WASP/Las17p-interacting protein Bzz1p functions with Myo5p in an early stage of endocytosis. Protoplasma 226(1-2):89-101 |
SGD |
| CDC50/YCR094W | IGI: Inferred from Genetic Interaction with SGD:ERG3 Assigned on 2005-12-08 |
manually curated | Kishimoto T, et al. (2005) Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeast. Mol Biol Cell 16(12):5592-609 |
SGD |
| CHC1/YGL206C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2006-08-31 |
manually curated | Newpher TM and Lemmon SK (2006) Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeast. Traffic 7(5):574-88 |
SGD |
| CLC1/YGR167W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:SLA2 Assigned on 2006-08-31 |
manually curated | Newpher TM and Lemmon SK (2006) Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeast. Traffic 7(5):574-88 |
SGD |
| COS10/YNR075W | IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04 |
manually curated | Wiederkehr A, et al. (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73 |
SGD |
| CUP5/YEL027W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Umemoto N, et al. (1990) Roles of the VMA3 gene product, subunit c of the vacuolar membrane H(+)-ATPase on vacuolar acidification and protein transport. A study with VMA3-disrupted mutants of Saccharomyces cerevisiae. J Biol Chem 265(30):18447-53 |
SGD |
| DNF1/YER166W | IGI: Inferred from Genetic Interaction with SGD:DRS2, SGD:DNF2, IMP: Inferred from Mutant Phenotype Assigned on 2005-04-21 |
manually curated | Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-54 |
SGD |
| DNF2/YDR093W | IGI: Inferred from Genetic Interaction with SGD:DRS2, SGD:DNF1, IMP: Inferred from Mutant Phenotype Assigned on 2005-04-21 |
manually curated | Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-54 |
SGD |
| DOA4/YDR069C | IMP: Inferred from Mutant Phenotype Assigned on 2003-10-21 |
manually curated | Lucero P and Lagunas R (1997) Catabolite inactivation of the yeast maltose transporter requires ubiquitin-ligase npi1/rsp5 and ubiquitin-hydrolase npi2/doa4. FEMS Microbiol Lett 147(2):273-7 |
SGD |
| DRS2/YAL026C | IGI: Inferred from Genetic Interaction with SGD:DNF2, SGD:DNF1 Assigned on 2006-10-12 |
manually curated | Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-54 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:ERG3 Assigned on 2005-12-08 |
manually curated | Kishimoto T, et al. (2005) Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeast. Mol Biol Cell 16(12):5592-609 |
SGD | |
| EDE1/YBL047C | IMP: Inferred from Mutant Phenotype Assigned on 2001-02-06 |
manually curated | Gagny B, et al. (2000) A novel EH domain protein of Saccharomyces cerevisiae, Ede1p, involved in endocytosis. J Cell Sci 113 ( Pt 18)():3309-19 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| END3/YNL084C | IMP: Inferred from Mutant Phenotype Assigned on 2009-09-28 |
manually curated | Raths S, et al. (1993) end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae. J Cell Biol 120(1):55-65 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ENT1/YDL161W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Wendland B, et al. (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ENT2/YLR206W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Wendland B, et al. (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ENT3/YJR125C | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Wendland B, et al. (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93 |
SGD |
| ENT4/YLL038C | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Wendland B, et al. (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93 |
SGD |
| ENT5/YDR153C | RCA: Reviewed Computational Analysis Assigned on 2009-09-03 |
computational | Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7 |
YeastFunc |
| ERG3/YLR056W | IGI: Inferred from Genetic Interaction with SGD:DRS2, SGD:CDC50 Assigned on 2005-12-08 |
manually curated | Kishimoto T, et al. (2005) Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeast. Mol Biol Cell 16(12):5592-609 |
SGD |
| FEN2/YCR028C | IMP: Inferred from Mutant Phenotype Assigned on 2004-07-12 |
manually curated | Care A, et al. (2004) A synthetic lethal screen identifies a role for the cortical actin patch/endocytosis complex in the response to nutrient deprivation in Saccharomyces cerevisiae. Genetics 166(2):707-19 |
SGD |
| FTH1/YBR207W | IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04 |
manually curated | Wiederkehr A, et al. (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73 |
SGD |
| GTS1/YGL181W | IMP: Inferred from Mutant Phenotype Assigned on 2007-09-13 |
manually curated | Yaguchi S, et al. (2007) Localization of Gts1p in cortical actin patches of yeast and its possible role in endocytosis. Eur J Cell Biol 86(5):275-85 |
SGD |
| GVP36/YIL041W | IMP: Inferred from Mutant Phenotype Assigned on 2008-06-01 |
manually curated | Querin L, et al. (2008) Proteomic Analysis of a Nutritional Shift-up in Saccharomyces cerevisiae Identifies Gvp36 as a BAR-containing Protein Involved in Vesicular Traffic and Nutritional Adaptation. J Biol Chem 283(8):4730-43 |
SGD |
| HES1/YOR237W | IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH2, SGD:OSH7, SGD:OSH3, SGD:OSH6, SGD:KES1 Assigned on 2006-10-20 |
manually curated | Beh CT and Rine J (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96 |
SGD |
This diagram shows the local area of the Gene Ontology and the numbers of yeast genes annotated to each term in the diagram. Within the diagram, click on the blue arrow to navigate up the tree and click on a GO term name to go to its GO term page.
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