GO term: endocytosis 
Ontology: Biological Process (GO:0006897)
Definition: A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
Synonyms: nonselective vesicle endocytosis; plasma membrane invagination; vesicle endocytosis
View Ontology:
(graph) | 
(text)
Definition: A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
Synonyms: nonselective vesicle endocytosis; plasma membrane invagination; vesicle endocytosis
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
endocytosis (88 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | endocytosis | 76 |
| High-throughput | none | none |
| Computational (download data) | endocytosis | 23 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
endocytosis or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| endocytosis 88 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ACT1/YFL039C | IMP: Inferred from Mutant Phenotype Assigned on 2009-03-11 |
manually curated | Munn AL, et al. (1995) end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 6(12):1721-42 |
SGD |
| AKR2/YOR034C | ISS: Inferred from Sequence or structural Similarity Assigned on 2005-05-10 |
manually curated | Givan SA and Sprague GF Jr (1997) The ankyrin repeat-containing protein Akr1p is required for the endocytosis of yeast pheromone receptors. Mol Biol Cell 8(7):1317-27 |
SGD |
| ARF3/YOR094W | IGI: Inferred from Genetic Interaction with SGD:SLA1, IMP: Inferred from Mutant Phenotype Assigned on 2010-01-12 |
manually curated | Smaczynska-de Rooij II, et al. (2008) Yeast Arf3p Modulates Plasma Membrane PtdIns(4,5)P2 Levels to Facilitate Endocytosis. Traffic 9(4):559-73 |
SGD |
| ART10/YLR392C | IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| ART5/YGR068C | IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| ARV1/YLR242C | IMP: Inferred from Mutant Phenotype Assigned on 2012-03-09 |
manually curated | Beh CT and Rine J (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96 |
SGD |
| BRE4/YDL231C | IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04 |
manually curated | Wiederkehr A, et al. (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73 |
SGD |
| BSP1/YPR171W | IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| BZZ1/YHR114W | IGI: Inferred from Genetic Interaction with SGD:MYO5 Assigned on 2006-10-25 |
manually curated | Soulard A, et al. (2005) The WASP/Las17p-interacting protein Bzz1p functions with Myo5p in an early stage of endocytosis. Protoplasma 226(1-2):89-101 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| CDC50/YCR094W | IGI: Inferred from Genetic Interaction with SGD:ERG3 Assigned on 2005-12-08 |
manually curated | Kishimoto T, et al. (2005) Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeast. Mol Biol Cell 16(12):5592-609 |
SGD |
| CHC1/YGL206C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2006-08-31 |
manually curated | Newpher TM and Lemmon SK (2006) Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeast. Traffic 7(5):574-88 |
SGD |
| CLC1/YGR167W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:SLA2 Assigned on 2006-08-31 |
manually curated | Newpher TM and Lemmon SK (2006) Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeast. Traffic 7(5):574-88 |
SGD |
| COF1/YLL050C | IMP: Inferred from Mutant Phenotype Assigned on 2013-01-30 |
manually curated | Curwin AJ, et al. (2012) Cofilin-mediated sorting and export of specific cargo from the Golgi apparatus in yeast. Mol Biol Cell 23(12):2327-38 |
SGD |
| COS10/YNR075W | IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04 |
manually curated | Wiederkehr A, et al. (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73 |
SGD |
| DNF1/YER166W | IGI: Inferred from Genetic Interaction with SGD:DRS2, SGD:DNF2, IMP: Inferred from Mutant Phenotype Assigned on 2005-04-21 |
manually curated | Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-54 |
SGD |
| DNF2/YDR093W | IGI: Inferred from Genetic Interaction with SGD:DNF1, SGD:DRS2, IMP: Inferred from Mutant Phenotype Assigned on 2005-04-21 |
manually curated | Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-54 |
SGD |
| DOA4/YDR069C | IMP: Inferred from Mutant Phenotype Assigned on 2003-10-21 |
manually curated | Lucero P and Lagunas R (1997) Catabolite inactivation of the yeast maltose transporter requires ubiquitin-ligase npi1/rsp5 and ubiquitin-hydrolase npi2/doa4. FEMS Microbiol Lett 147(2):273-7 |
SGD |
| DRS2/YAL026C | IGI: Inferred from Genetic Interaction with SGD:DNF1, SGD:DNF2 Assigned on 2006-10-12 |
manually curated | Pomorski T, et al. (2003) Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis. Mol Biol Cell 14(3):1240-54 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:ERG3 Assigned on 2005-12-08 |
manually curated | Kishimoto T, et al. (2005) Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeast. Mol Biol Cell 16(12):5592-609 |
SGD | |
| EDE1/YBL047C | IMP: Inferred from Mutant Phenotype Assigned on 2001-02-06 |
manually curated | Gagny B, et al. (2000) A novel EH domain protein of Saccharomyces cerevisiae, Ede1p, involved in endocytosis. J Cell Sci 113 ( Pt 18)():3309-19 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| END3/YNL084C | IMP: Inferred from Mutant Phenotype Assigned on 2009-09-28 |
manually curated | Raths S, et al. (1993) end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae. J Cell Biol 120(1):55-65 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR025604 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ENT1/YDL161W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Wendland B, et al. (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ENT2/YLR206W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Wendland B, et al. (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ENT3/YJR125C | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Wendland B, et al. (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93 |
SGD |
| ENT4/YLL038C | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Wendland B, et al. (1999) Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J 18(16):4383-93 |
SGD |
| FEN2/YCR028C | IMP: Inferred from Mutant Phenotype Assigned on 2004-07-12 |
manually curated | Care A, et al. (2004) A synthetic lethal screen identifies a role for the cortical actin patch/endocytosis complex in the response to nutrient deprivation in Saccharomyces cerevisiae. Genetics 166(2):707-19 |
SGD |
| FTH1/YBR207W | IMP: Inferred from Mutant Phenotype Assigned on 2002-10-04 |
manually curated | Wiederkehr A, et al. (2001) Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast 18(8):759-73 |
SGD |
| GTS1/YGL181W | IMP: Inferred from Mutant Phenotype Assigned on 2007-09-13 |
manually curated | Yaguchi S, et al. (2007) Localization of Gts1p in cortical actin patches of yeast and its possible role in endocytosis. Eur J Cell Biol 86(5):275-85 |
SGD |
| GVP36/YIL041W | IMP: Inferred from Mutant Phenotype Assigned on 2008-06-01 |
manually curated | Querin L, et al. (2008) Proteomic Analysis of a Nutritional Shift-up in Saccharomyces cerevisiae Identifies Gvp36 as a BAR-containing Protein Involved in Vesicular Traffic and Nutritional Adaptation. J Biol Chem 283(8):4730-43 |
SGD |
| HES1/YOR237W | IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH2, SGD:OSH3, SGD:KES1, SGD:OSH6, SGD:OSH7 Assigned on 2006-10-20 |
manually curated | Beh CT and Rine J (2004) A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution. J Cell Sci 117(Pt 14):2983-96 |
SGD |
| INP51/YIL002C | IEA: Inferred from Electronic Annotation with EBI:KW-0254 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
