Ontology: Biological Process (GO:0006890)

Definition: The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

Synonyms: retrograde (Golgi to ER) transport; retrograde transport, Golgi to endoplasmic reticulum; retrograde transport, Golgi to ER; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; cis-Golgi to rough endoplasmic reticulum transport; cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport; cis-Golgi to rough ER transport; cis-Golgi to rough ER vesicle-mediated transport

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term retrograde vesicle-mediated transport, Golgi to ER (28 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	retrograde vesicle-mediated transport, Golgi to ER	27
High-throughput	none	none
Computational (download data)	retrograde vesicle-mediated transport, Golgi to ER	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term retrograde vesicle-mediated transport, Golgi to ER or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

retrograde vesicle-mediated transport, Golgi to ER      28 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
BET1/YIL004C	IDA: Inferred from Direct Assay Assigned on 2002-07-16	manually curated	Spang A and Schekman R  (1998) Reconstitution of retrograde transport from the Golgi to the ER in vitro. J Cell Biol 143(3):589-99	SGD
COP1/YDL145C	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-07	manually curated	Letourneur F, et al.  (1994) Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell 79(7):1199-207	SGD
DSL1/YNL258C	IMP: Inferred from Mutant Phenotype Assigned on 2002-12-09	manually curated	Reilly BA, et al.  (2001) Golgi-to-endoplasmic reticulum (ER) retrograde traffic in yeast requires Dsl1p, a component of the ER target site that interacts with a COPI coat subunit. Mol Biol Cell 12(12):3783-96	SGD
GCS1/YDL226C	IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Poon PP, et al.  (1999) Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function. EMBO J 18(3):555-64	SGD
GEA1/YJR031C	IGI: Inferred from Genetic Interaction with SGD:GEA2 Assigned on 2005-01-04	manually curated	Spang A, et al.  (2001) The ADP ribosylation factor-nucleotide exchange factors Gea1p and Gea2p have overlapping, but not redundant functions in retrograde transport from the Golgi to the endoplasmic reticulum. Mol Biol Cell 12(4):1035-45	SGD
GEA2/YEL022W	IGI: Inferred from Genetic Interaction with SGD:SEC21 Assigned on 2005-01-04	manually curated	Spang A, et al.  (2001) The ADP ribosylation factor-nucleotide exchange factors Gea1p and Gea2p have overlapping, but not redundant functions in retrograde transport from the Golgi to the endoplasmic reticulum. Mol Biol Cell 12(4):1035-45	SGD
GET1/YGL020C	IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction with SGD:ERD2, IMP: Inferred from Mutant Phenotype Assigned on 2005-11-10	manually curated	Schuldiner M, et al.  (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19	SGD
GET2/YER083C	IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction with SGD:ERD2, IMP: Inferred from Mutant Phenotype Assigned on 2005-11-10	manually curated	Schuldiner M, et al.  (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19	SGD
GET3/YDL100C	IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction with SGD:ERD2, IMP: Inferred from Mutant Phenotype Assigned on 2005-11-10	manually curated	Schuldiner M, et al.  (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19	SGD
GLO3/YER122C	IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Poon PP, et al.  (1999) Retrograde transport from the yeast Golgi is mediated by two ARF GAP proteins with overlapping function. EMBO J 18(3):555-64	SGD
NEO1/YIL048W	IMP: Inferred from Mutant Phenotype Assigned on 2004-10-01	manually curated	Hua Z and Graham TR  (2003) Requirement for neo1p in retrograde transport from the Golgi complex to the endoplasmic reticulum. Mol Biol Cell 14(12):4971-83	SGD
RER1/YCL001W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2004-07-15	manually curated	Sato K, et al.  (2001) Rer1p, a retrieval receptor for endoplasmic reticulum membrane proteins, is dynamically localized to the Golgi apparatus by coatomer. J Cell Biol 152(5):935-44	SGD
RET2/YFR051C	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-20	manually curated	Cosson P, et al.  (1996) Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval. EMBO J 15(8):1792-8	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR027059 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RET3/YPL010W	IMP: Inferred from Mutant Phenotype Assigned on 2002-06-20	manually curated	Cosson P, et al.  (1996) Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval. EMBO J 15(8):1792-8	SGD
SEC20/YDR498C	IMP: Inferred from Mutant Phenotype Assigned on 2010-07-07	manually curated	Lewis MJ and Pelham HR  (1996) SNARE-mediated retrograde traffic from the Golgi complex to the endoplasmic reticulum. Cell 85(2):205-15	SGD
SEC21/YNL287W	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-07	manually curated	Letourneur F, et al.  (1994) Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell 79(7):1199-207	SGD
SEC22/YLR268W	IMP: Inferred from Mutant Phenotype Assigned on 2010-07-02	manually curated	Spang A and Schekman R  (1998) Reconstitution of retrograde transport from the Golgi to the ER in vitro. J Cell Biol 143(3):589-99	SGD
SEC27/YGL137W	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-07	manually curated	Letourneur F, et al.  (1994) Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum. Cell 79(7):1199-207	SGD
SEC28/YIL076W	IEA: Inferred from Electronic Annotation with EBI:IPR006822 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SEC39/YLR440C	IGI: Inferred from Genetic Interaction with SGD:DSL1, SGD:SLY1, IPI: Inferred from Physical Interaction with SGD:DSL1 Assigned on 2008-07-23	manually curated	Kraynack BA, et al.  (2005) Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast. Mol Biol Cell 16(9):3963-77	SGD
SLY1/YDR189W	IMP: Inferred from Mutant Phenotype Assigned on 2008-02-14	manually curated	Li Y, et al.  (2005) Structure-based functional analysis reveals a role for the SM protein Sly1p in retrograde transport to the endoplasmic reticulum. Mol Biol Cell 16(9):3951-62	SGD
TIP20/YGL145W	IGI: Inferred from Genetic Interaction Assigned on 2002-09-30	manually curated	Frigerio G  (1998) The Saccharomyces cerevisiae early secretion mutant tip20 is synthetic lethal with mutants in yeast coatomer and the SNARE proteins Sec22p and Ufe1p. Yeast 14(7):633-46	SGD
TRX1/YLR043C	IDA: Inferred from Direct Assay Assigned on 2005-06-21	manually curated	Spang A and Schekman R  (1998) Reconstitution of retrograde transport from the Golgi to the ER in vitro. J Cell Biol 143(3):589-99	SGD
TRX2/YGR209C	IDA: Inferred from Direct Assay Assigned on 2005-06-21	manually curated	Spang A and Schekman R  (1998) Reconstitution of retrograde transport from the Golgi to the ER in vitro. J Cell Biol 143(3):589-99	SGD
UFE1/YOR075W	IMP: Inferred from Mutant Phenotype Assigned on 2010-07-01	manually curated	Lewis MJ and Pelham HR  (1996) SNARE-mediated retrograde traffic from the Golgi complex to the endoplasmic reticulum. Cell 85(2):205-15	SGD
USE1/YGL098W	IMP: Inferred from Mutant Phenotype Assigned on 2003-07-17	manually curated	Dilcher M, et al.  (2003) Use1p is a yeast SNARE protein required for retrograde traffic to the ER. EMBO J 22(14):3664-74	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2010-07-01	manually curated	Burri L, et al.  (2003) A SNARE required for retrograde transport to the endoplasmic reticulum. Proc Natl Acad Sci U S A 100(17):9873-7	SGD
VPS74/YDR372C	IMP: Inferred from Mutant Phenotype Assigned on 2008-08-04	manually curated	Tu L, et al.  (2008) Signal-mediated dynamic retention of glycosyltransferases in the Golgi. Science 321(5887):404-7	SGD
YPT1/YFL038C	IGI: Inferred from Genetic Interaction with SGD:SLY1, IMP: Inferred from Mutant Phenotype Assigned on 2008-09-11	manually curated	Kamena F, et al.  (2008) Ypt1p is essential for retrograde Golgi-ER transport and for Golgi maintenance in S. cerevisiae. J Cell Sci 121(Pt 8):1293-302	SGD

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