Ontology: Biological Process (GO:0006888)

Definition: The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.

Synonyms: endoplasmic reticulum to Golgi transport; endoplasmic reticulum to Golgi vesicle-mediated transport; ER to Golgi transport; rough endoplasmic reticulum to cis-Golgi transport; rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport; rough ER to cis-Golgi transport; rough ER to cis-Golgi vesicle-mediated transport

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term ER to Golgi vesicle-mediated transport (80 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	ER to Golgi vesicle-mediated transport	73
High-throughput	none	none
Computational (download data)	ER to Golgi vesicle-mediated transport	12

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term ER to Golgi vesicle-mediated transport or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

ER to Golgi vesicle-mediated transport      80 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
AGE1/YDR524C	IGI: Inferred from Genetic Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-04-11	manually curated	Zhang CJ, et al.  (1998) A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae. J Biol Chem 273(31):19792-6	SGD
AGE2/YIL044C	IGI: Inferred from Genetic Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-04-11	manually curated	Zhang CJ, et al.  (1998) A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae. J Biol Chem 273(31):19792-6	SGD
ARF1/YDL192W	IDA: Inferred from Direct Assay Assigned on 2007-03-29	manually curated	Spang A and Schekman R  (1998) Reconstitution of retrograde transport from the Golgi to the ER in vitro. J Cell Biol 143(3):589-99	SGD
	IDA: Inferred from Direct Assay Assigned on 2007-03-29	manually curated	Spang A, et al.  (1998) Coatomer, Arf1p, and nucleotide are required to bud coat protein complex I-coated vesicles from large synthetic liposomes. Proc Natl Acad Sci U S A 95(19):11199-204	SGD
ARF2/YDL137W	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Moss J and Vaughan M  (1999) Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factors. Mol Cell Biochem 193(1-2):153-7	SGD
	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Moss J and Vaughan M  (1998) Molecules in the ARF orbit. J Biol Chem 273(34):21431-4	SGD
ATG8/YBL078C	IGI: Inferred from Genetic Interaction with SGD:BET1, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:BET1 Assigned on 2008-05-13	manually curated	Legesse-Miller A, et al.  (2000) Aut7p, a soluble autophagic factor, participates in multiple membrane trafficking processes. J Biol Chem 275(42):32966-73	SGD
BET1/YIL004C	IPI: Inferred from Physical Interaction Assigned on 2002-07-16	manually curated	Otte S, et al.  (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2002-07-16	manually curated	Newman AP and Ferro-Novick S  (1987) Characterization of new mutants in the early part of the yeast secretory pathway isolated by a [3H]mannose suicide selection. J Cell Biol 105(4):1587-94	SGD
BET2/YPR176C	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-27	manually curated	Li R, et al.  (1993) The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase. Nature 366(6450):82-4	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-18	manually curated	Newman AP and Ferro-Novick S  (1987) Characterization of new mutants in the early part of the yeast secretory pathway isolated by a [3H]mannose suicide selection. J Cell Biol 105(4):1587-94	SGD
BET3/YKR068C	IGI: Inferred from Genetic Interaction with SGD:BET1, SGD:SEC21, SGD:SEC22, SGD:YPT1, SGD:SEC17, SGD:SEC18, SGD:BOS1, IMP: Inferred from Mutant Phenotype Assigned on 2010-11-08	manually curated	Rossi G, et al.  (1995) BET3 encodes a novel hydrophilic protein that acts in conjunction with yeast SNAREs. Mol Biol Cell 6(12):1769-80	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2010-11-19	manually curated	Sacher M, et al.  (2001) TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport. Mol Cell 7(2):433-42	SGD
BET4/YJL031C	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-27	manually curated	Li R, et al.  (1993) The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase. Nature 366(6450):82-4	SGD
BET5/YML077W	IMP: Inferred from Mutant Phenotype Assigned on 2010-11-19	manually curated	Sacher M, et al.  (2001) TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport. Mol Cell 7(2):433-42	SGD
	IGI: Inferred from Genetic Interaction with SGD:BET1, SGD:BET3, SGD:YPT1, SGD:BOS1, SGD:DSS4, SGD:SEC2, SGD:USO1, IMP: Inferred from Mutant Phenotype Assigned on 2010-11-08	manually curated	Jiang Y, et al.  (1998) A high copy suppressor screen reveals genetic interactions between BET3 and a new gene. Evidence for a novel complex in ER-to-Golgi transport. Genetics 149(2):833-41	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR007233 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BOS1/YLR078C	IMP: Inferred from Mutant Phenotype Assigned on 2010-06-29	manually curated	Lian JP and Ferro-Novick S  (1993) Bos1p, an integral membrane protein of the endoplasmic reticulum to Golgi transport vesicles, is required for their fusion competence. Cell 73(4):735-45	SGD
BST1/YFL025C	IMP: Inferred from Mutant Phenotype Assigned on 2005-04-25	manually curated	Elrod-Erickson MJ and Kaiser CA  (1996) Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations. Mol Biol Cell 7(7):1043-58	SGD
BUG1/YDL099W	IPI: Inferred from Physical Interaction with SGD:GRH1, SGD:USO1 Assigned on 2005-11-11	manually curated	Schuldiner M, et al.  (2005) Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 123(3):507-19	SGD
	IGI: Inferred from Genetic Interaction with SGD:USO1, SGD:YPT1, SGD:SLY1, IMP: Inferred from Mutant Phenotype Assigned on 2007-06-05	manually curated	Behnia R, et al.  (2007) The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic. J Cell Biol 176(3):255-61	SGD
CHS7/YHR142W	IDA: Inferred from Direct Assay Assigned on 2002-08-07	manually curated	Trilla JA, et al.  (1999) Chs7p, a new protein involved in the control of protein export from the endoplasmic reticulum that is specifically engaged in the regulation of chitin synthesis in Saccharomyces cerevisiae. J Cell Biol 145(6):1153-63	SGD
COG2/YGR120C	IGI: Inferred from Genetic Interaction Assigned on 2001-11-05	manually curated	Kim DW, et al.  (1999) High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking. Mol Biol Cell 10(10):3317-29	SGD
COG3/YER157W	IGI: Inferred from Genetic Interaction Assigned on 2001-11-05	manually curated	Kim DW, et al.  (1999) High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking. Mol Biol Cell 10(10):3317-29	SGD
COP1/YDL145C	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-07	manually curated	Sutterlin C, et al.  (1997) Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast. J Cell Sci 110 ( Pt 21):2703-14	SGD
EMP24/YGL200C	IPI: Inferred from Physical Interaction Assigned on 2002-07-16	manually curated	Otte S, et al.  (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2005-04-25	manually curated	Elrod-Erickson MJ and Kaiser CA  (1996) Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations. Mol Biol Cell 7(7):1043-58	SGD
EMP46/YLR080W	IGI: Inferred from Genetic Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-12-09	manually curated	Sato K and Nakano A  (2002) Emp47p and its close homolog Emp46p have a tyrosine-containing endoplasmic reticulum exit signal and function in glycoprotein secretion in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2518-32	SGD
EMP47/YFL048C	IPI: Inferred from Physical Interaction Assigned on 2002-07-16	manually curated	Otte S, et al.  (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18	SGD
ERD2/YBL040C	IMP: Inferred from Mutant Phenotype Assigned on 2007-01-25	manually curated	Lewis MJ, et al.  (1990) The ERD2 gene determines the specificity of the luminal ER protein retention system. Cell 61(7):1359-63	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-01-25	manually curated	Aoe T, et al.  (1997) The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1. EMBO J 16(24):7305-16	SGD
ERP1/YAR002C-A	IPI: Inferred from Physical Interaction Assigned on 2002-07-16	manually curated	Otte S, et al.  (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18	SGD
ERP2/YAL007C	IPI: Inferred from Physical Interaction Assigned on 2002-07-16	manually curated	Otte S, et al.  (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18	SGD
ERP4/YOR016C	IGI: Inferred from Genetic Interaction with SGD:ERP2 Assigned on 2008-07-24	manually curated	Marzioch M, et al.  (1999) Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex. Mol Biol Cell 10(6):1923-38	SGD
ERP6/YGL002W	IGI: Inferred from Genetic Interaction with SGD:ERP1 Assigned on 2008-07-24	manually curated	Marzioch M, et al.  (1999) Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex. Mol Biol Cell 10(6):1923-38	SGD
ERV14/YGL054C	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Powers J and Barlowe C  (1998) Transport of axl2p depends on erv14p, an ER-vesicle protein related to the Drosophila cornichon gene product. J Cell Biol 142(5):1209-22	SGD
	IPI: Inferred from Physical Interaction Assigned on 2002-07-16	manually curated	Otte S, et al.  (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18	SGD
ERV15/YBR210W	IGI: Inferred from Genetic Interaction with SGD:ERV14 Assigned on 2007-02-22	manually curated	Nakanishi H, et al.  (2007) Erv14 family cargo receptors are necessary for ER exit during sporulation in Saccharomyces cerevisiae. J Cell Sci 120(Pt 5):908-16	SGD
ERV25/YML012W	IPI: Inferred from Physical Interaction Assigned on 2002-07-16	manually curated	Otte S, et al.  (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18	SGD
ERV29/YGR284C	IPI: Inferred from Physical Interaction Assigned on 2002-07-16	manually curated	Otte S, et al.  (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18	SGD
ERV41/YML067C	IPI: Inferred from Physical Interaction Assigned on 2002-07-16	manually curated	Otte S, et al.  (2001) Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol 152(3):503-18	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR027198 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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