GO term: exocytosis 
Ontology: Biological Process (GO:0006887)
Definition: A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells.
Synonyms: nonselective vesicle exocytosis; vesicle exocytosis
View Ontology:
(graph) | 
(text)
Definition: A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells.
Synonyms: nonselective vesicle exocytosis; vesicle exocytosis
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
exocytosis (43 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | exocytosis | 40 |
| High-throughput | none | none |
| Computational (download data) | exocytosis | 17 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
exocytosis or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| exocytosis 43 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ACT1/YFL039C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85 |
SGD |
| EXO70/YJL085W | IGI: Inferred from Genetic Interaction with SGD:SEC1, SGD:SEC4 Assigned on 2012-07-25 |
manually curated | Wiederkehr A, et al. (2004) Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p. J Cell Biol 167(5):875-87 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2012-07-24 |
manually curated | He B, et al. (2007) Exo70p mediates the secretion of specific exocytic vesicles at early stages of the cell cycle for polarized cell growth. J Cell Biol 176(6):771-7 |
SGD | |
| IGI: Inferred from Genetic Interaction with SGD:SEC3 Assigned on 2008-09-04 |
manually curated | He B, et al. (2007) Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane. EMBO J 26(18):4053-65 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR004140 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| EXO84/YBR102C | IGI: Inferred from Genetic Interaction with SGD:SEC5, IMP: Inferred from Mutant Phenotype Assigned on 2004-07-30 |
manually curated | Guo W, et al. (1999) Exo84p is an exocyst protein essential for secretion. J Biol Chem 274(33):23558-64 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2012-07-26 |
manually curated | Zhang X, et al. (2005) The critical role of Exo84p in the organization and polarized localization of the exocyst complex. J Biol Chem 280(21):20356-64 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| GYL1/YMR192W | IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| GYP5/YPL249C | IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| HES1/YOR237W | IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH2, SGD:OSH3, SGD:KES1, SGD:OSH6, SGD:OSH7, SGD:RHO1 Assigned on 2006-11-30 |
manually curated | Kozminski KG, et al. (2006) Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae. Traffic 7(9):1224-42 |
SGD |
| KES1/YPL145C | IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH2, SGD:OSH3, SGD:HES1, SGD:OSH6, SGD:OSH7, SGD:RHO1, SGD:SEC3, SGD:SEC4, SGD:SEC5, SGD:MSB3, SGD:MSB4 Assigned on 2006-11-30 |
manually curated | Kozminski KG, et al. (2006) Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae. Traffic 7(9):1224-42 |
SGD |
| KIN1/YDR122W | IGI: Inferred from Genetic Interaction with SGD:RHO3, SGD:CDC42, SGD:SEC4, SGD:SEC15, SGD:SEC3, SGD:SEC10, SGD:SEC1, SGD:SEC2, IPI: Inferred from Physical Interaction with SGD:SEC9, SGD:SRO7 Assigned on 2007-08-21 |
manually curated | Elbert M, et al. (2005) The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery. Mol Biol Cell 16(2):532-49 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| KIN2/YLR096W | IGI: Inferred from Genetic Interaction with SGD:RHO3, SGD:CDC42, SGD:SEC4, SGD:SEC15, SGD:SEC3, SGD:SEC10, SGD:SEC1, SGD:SEC2, IPI: Inferred from Physical Interaction with SGD:SEC9, SGD:SRO7 Assigned on 2005-02-16 |
manually curated | Elbert M, et al. (2005) The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery. Mol Biol Cell 16(2):532-49 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| MSB3/YNL293W | IGI: Inferred from Genetic Interaction with SGD:MSB4, SGD:SEC3, SGD:SEC9 Assigned on 2013-03-06 |
manually curated | Gao XD, et al. (2003) The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. J Cell Biol 162(4):635-46 |
SGD |
| MSB4/YOL112W | IGI: Inferred from Genetic Interaction with SGD:MSB3, SGD:SEC9, SGD:SEC3 Assigned on 2013-03-06 |
manually curated | Gao XD, et al. (2003) The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. J Cell Biol 162(4):635-46 |
SGD |
| MYO3/YKL129C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85 |
SGD |
| MYO5/YMR109W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85 |
SGD |
| OSH2/YDL019C | IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH3, SGD:KES1, SGD:HES1, SGD:OSH6, SGD:OSH7, SGD:RHO1, SGD:SEC3, SGD:SEC4, SGD:SEC5, SGD:MSB3, SGD:MSB4 Assigned on 2006-11-30 |
manually curated | Kozminski KG, et al. (2006) Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae. Traffic 7(9):1224-42 |
SGD |
| OSH3/YHR073W | IGI: Inferred from Genetic Interaction with SGD:OSH7, SGD:SWH1, SGD:OSH2, SGD:KES1, SGD:HES1, SGD:OSH6 Assigned on 2006-11-30 |
manually curated | Kozminski KG, et al. (2006) Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae. Traffic 7(9):1224-42 |
SGD |
| OSH6/YKR003W | IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH2, SGD:OSH3, SGD:KES1, SGD:HES1, SGD:OSH7, SGD:RHO1 Assigned on 2006-11-30 |
manually curated | Kozminski KG, et al. (2006) Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae. Traffic 7(9):1224-42 |
SGD |
| OSH7/YHR001W | IGI: Inferred from Genetic Interaction with SGD:SWH1, SGD:OSH2, SGD:OSH3, SGD:KES1, SGD:HES1, SGD:OSH6, SGD:RHO1 Assigned on 2006-11-30 |
manually curated | Kozminski KG, et al. (2006) Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae. Traffic 7(9):1224-42 |
SGD |
| PMR1/YGL167C | IGI: Inferred from Genetic Interaction with SGD:SEC15, SGD:GDI1, SGD:SEC21, SGD:YPT1, SGD:SEC9, SGD:SEC10, SGD:SEC13, SGD:SEC6 Assigned on 2008-08-01 |
manually curated | Antebi A and Fink GR (1992) The yeast Ca(2+)-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution. Mol Biol Cell 3(6):633-54 |
SGD |
| RCY1/YJL204C | IEA: Inferred from Electronic Annotation with EBI:IPR009976 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| SEC1/YDR164C | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-01-18 |
manually curated | Carr CM, et al. (1999) Sec1p binds to SNARE complexes and concentrates at sites of secretion. J Cell Biol 146(2):333-44 |
SGD |
| SEC10/YLR166C | IMP: Inferred from Mutant Phenotype Assigned on 2012-07-12 |
manually curated | Novick P, et al. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR009976 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SEC15/YGL233W | IMP: Inferred from Mutant Phenotype Assigned on 2012-07-12 |
manually curated | Novick P, et al. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SEC2/YNL272C | IMP: Inferred from Mutant Phenotype Assigned on 2002-07-29 |
manually curated | Ortiz D, et al. (2002) Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast. J Cell Biol 157(6):1005-15 |
SGD |
| SEC3/YER008C | IMP: Inferred from Mutant Phenotype Assigned on 2012-07-12 |
manually curated | Novick P, et al. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:SEC9, SGD:MSB3, SGD:MSB4 Assigned on 2013-03-06 |
manually curated | Gao XD, et al. (2003) The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. J Cell Biol 162(4):635-46 |
SGD | |
| IDA: Inferred from Direct Assay Assigned on 2006-06-19 |
manually curated | VerPlank L and Li R (2005) Cell cycle-regulated trafficking of Chs2 controls actomyosin ring stability during cytokinesis. Mol Biol Cell 16(5):2529-43 |
SGD | |
| IGI: Inferred from Genetic Interaction with SGD:EXO70 Assigned on 2008-09-04 |
manually curated | He B, et al. (2007) Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane. EMBO J 26(18):4053-65 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SEC4/YFL005W | IDA: Inferred from Direct Assay Assigned on 2006-06-19 |
manually curated | VerPlank L and Li R (2005) Cell cycle-regulated trafficking of Chs2 controls actomyosin ring stability during cytokinesis. Mol Biol Cell 16(5):2529-43 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SEC5/YDR166C | IMP: Inferred from Mutant Phenotype Assigned on 2012-07-12 |
manually curated | Novick P, et al. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:SEC1, SGD:SEC4 Assigned on 2012-07-25 |
manually curated | Wiederkehr A, et al. (2004) Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p. J Cell Biol 167(5):875-87 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SEC6/YIL068C | IMP: Inferred from Mutant Phenotype Assigned on 2012-07-12 |
manually curated | Novick P, et al. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR010326 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SEC8/YPR055W | IMP: Inferred from Mutant Phenotype Assigned on 2012-07-12 |
manually curated | Novick P, et al. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0268 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SEC9/YGR009C | IGI: Inferred from Genetic Interaction with SGD:MSB3, SGD:SEC3, SGD:MSB4 Assigned on 2013-03-06 |
manually curated | Gao XD, et al. (2003) The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization. J Cell Biol 162(4):635-46 |
SGD |
| SEM1/YDR363W-A | IGI: Inferred from Genetic Interaction, IPI: Inferred from Physical Interaction Assigned on 2002-12-16 |
manually curated | Jantti J, et al. (1999) SEM1, a homologue of the split hand/split foot malformation candidate gene Dss1, regulates exocytosis and pseudohyphal differentiation in yeast. Proc Natl Acad Sci U S A 96(3):909-14 |
SGD |
