GO term: ergosterol biosynthetic process 
Ontology: Biological Process (GO:0006696)
Definition: The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
Synonyms: ergosterol anabolism; ergosterol biosynthesis; ergosterol formation; ergosterol synthesis
Definition: The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds.
Synonyms: ergosterol anabolism; ergosterol biosynthesis; ergosterol formation; ergosterol synthesis
This table lists the methods used to annotate genes either directly to the term
ergosterol biosynthetic process (24 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | ergosterol biosynthetic process | 24 |
| High-throughput | none | none |
| Computational (download data) | ergosterol biosynthetic process | 1 |
Links to Additional Annotations:
Annotation details for genes that have been directly annotated to the term
ergosterol biosynthetic process or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| ergosterol biosynthetic process 24 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ERG1/YGR175C | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG10/YPL028W | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG11/YHR007C | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG12/YMR208W | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG13/YML126C | IMP: Inferred from Mutant Phenotype Assigned on 2006-06-05 |
manually curated | Servouse M, et al. (1984) Isolation and characterization of yeast mutants blocked in mevalonic acid formation. Biochem Biophys Res Commun 123(2):424-30 |
SGD |
| ERG2/YMR202W | IMP: Inferred from Mutant Phenotype Assigned on 2008-05-14 |
manually curated | Rahier A, et al. (2008) Identification of essential amino acid residues in a sterol 8,7-isomerase from Zea mays reveals functional homology and diversity with the isomerases of animal and fungal origin. Biochem J 414(2):247-59 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR006716 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB | |
| ERG20/YJL167W | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG24/YNL280C | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG25/YGR060W | IDA: Inferred from Direct Assay Assigned on 2001-01-18 |
manually curated | Li L and Kaplan J (1996) Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue. J Biol Chem 271(28):16927-33 |
SGD |
| ERG26/YGL001C | IDA: Inferred from Direct Assay Assigned on 2001-01-18 |
manually curated | Gachotte D, et al. (1998) Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. Proc Natl Acad Sci U S A 95(23):13794-9 |
SGD |
| ERG27/YLR100W | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Gachotte D, et al. (1999) Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation. Proc Natl Acad Sci U S A 96(22):12655-60 |
SGD |
| ERG28/YER044C | IDA: Inferred from Direct Assay Assigned on 2001-04-26 |
manually curated | Gachotte D, et al. (2001) A novel gene conserved from yeast to humans is involved in sterol biosynthesis. J Lipid Res 42(1):150-4 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2001-04-26 |
manually curated | Hughes TR, et al. (2000) Functional discovery via a compendium of expression profiles. Cell 102(1):109-26 |
SGD | |
| IPI: Inferred from Physical Interaction Assigned on 2005-07-11 |
manually curated | Mo C and Bard M (2005) Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex. J Lipid Res 46(9):1991-8 |
SGD | |
| ERG3/YLR056W | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG4/YGL012W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Zweytick D, et al. (2000) Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast saccharomyces cerevisiae. FEBS Lett 470(1):83-7 |
SGD |
| ERG5/YMR015C | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG6/YML008C | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG7/YHR072W | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG8/YMR220W | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| ERG9/YHR190W | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| HMG1/YML075C | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| HMG2/YLR450W | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| IDI1/YPL117C | TAS: Traceable Author Statement Assigned on 2001-01-19 |
manually curated | Paltauf F, et al. (1992) "Regulation and compartmentalization of lipid synthesis in yeast." Pp. 415-500 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press |
SGD |
| MCR1/YKL150W | IDA: Inferred from Direct Assay Assigned on 2002-09-26 |
manually curated | Lamb DC, et al. (1999) Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Lett 462(3):283-8 |
SGD |
| NCP1/YHR042W | IMP: Inferred from Mutant Phenotype Assigned on 2002-04-19 |
manually curated | Venkateswarlu K, et al. (1998) The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in sterol biosynthesis or in reconstitution of CYP activity. J Biol Chem 273(8):4492-6 |
SGD |
This diagram shows the local area of the Gene Ontology and the numbers of yeast genes annotated to each term in the diagram. Within the diagram, click on the blue arrow to navigate up the tree and click on a GO term name to go to its GO term page.
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