Ontology: Biological Process (GO:0006661)

Definition: The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

Synonyms: phosphatidylinositol anabolism; phosphatidylinositol biosynthesis; phosphatidylinositol formation; phosphatidylinositol synthesis; phosphoinositide biosynthesis; PtdIns biosynthesis; PtdIns biosynthetic process; phosphoinositide biosynthetic process

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term phosphatidylinositol biosynthetic process (5 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	phosphatidylinositol biosynthetic process	4
High-throughput	none	none
Computational (download data)	phosphatidylinositol biosynthetic process	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term phosphatidylinositol biosynthetic process or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

phosphatidylinositol biosynthetic process      5 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CMD1/YBR109C	IGI: Inferred from Genetic Interaction with SGD:MSS4, IMP: Inferred from Mutant Phenotype Assigned on 2007-07-18	manually curated	Desrivieres S, et al.  (2002) Calmodulin controls organization of the actin cytoskeleton via regulation of phosphatidylinositol (4,5)-bisphosphate synthesis in Saccharomyces cerevisiae. Biochem J 366(Pt 3):945-51	SGD
PIK1/YNL267W	IEA: Inferred from Electronic Annotation with EBI:IPR027003 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PIS1/YPR113W	IMP: Inferred from Mutant Phenotype Assigned on 2005-03-11	manually curated	Nikawa J and Yamashita S  (1984) Molecular cloning of the gene encoding CDPdiacylglycerol-inositol 3-phosphatidyl transferase in Saccharomyces cerevisiae. Eur J Biochem 143(2):251-6	SGD
	IDA: Inferred from Direct Assay Assigned on 2010-06-11	manually curated	Fischl AS, et al.  (1986) Phosphatidylinositol synthase from Saccharomyces cerevisiae. Reconstitution, characterization, and regulation of activity. J Biol Chem 261(7):3178-83	SGD
VAC14/YLR386W	IGI: Inferred from Genetic Interaction with SGD:FAB1, IMP: Inferred from Mutant Phenotype Assigned on 2010-05-03	manually curated	Bonangelino CJ, et al.  (2002) Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p. J Cell Biol 156(6):1015-28	SGD
VPS30/YPL120W	IMP: Inferred from Mutant Phenotype Assigned on 2008-05-30	manually curated	Burda P, et al.  (2002) Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. J Cell Sci 115(Pt 20):3889-900	SGD

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