Ontology: Biological Process (GO:0006635)

Definition: A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term fatty acid beta-oxidation (9 genes) or to its variants containing one or more qualifiers (2 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	fatty acid beta-oxidation	9
	NOT: fatty acid beta-oxidation	2
High-throughput	none	none
Computational (download data)	fatty acid beta-oxidation	3

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term fatty acid beta-oxidation or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

fatty acid beta-oxidation      9 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ANT1/YPR128C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2001-10-04	manually curated	van Roermund CW, et al.  (2001) Identification of a peroxisomal ATP carrier required for medium-chain fatty acid beta-oxidation and normal peroxisome proliferation in Saccharomyces cerevisiae. Mol Cell Biol 21(13):4321-9	SGD
	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2001-10-04	manually curated	Palmieri L, et al.  (2001) Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter. EMBO J 20(18):5049-59	SGD
DCI1/YOR180C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Gurvitz A, et al.  (1999) Alternatives to the isomerase-dependent pathway for the beta-oxidation of oleic acid are dispensable in Saccharomyces cerevisiae. Identification of YOR180c/DCI1 encoding peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase. J Biol Chem 274(35):24514-21	SGD
ECI1/YLR284C	IDA: Inferred from Direct Assay Assigned on 2002-10-24	manually curated	Gurvitz A, et al.  (1998) Peroxisomal Delta3-cis-Delta2-trans-enoyl-CoA isomerase encoded by ECI1 is required for growth of the yeast Saccharomyces cerevisiae on unsaturated fatty acids. J Biol Chem 273(47):31366-74	SGD
	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Geisbrecht BV, et al.  (1998) Molecular characterization of Saccharomyces cerevisiae Delta3, Delta2-enoyl-CoA isomerase. J Biol Chem 273(50):33184-91	SGD
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00659 Last Updated 2013-03-02	computational	UniProt-GOA  (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
FOX2/YKR009C	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-23	manually curated	Hiltunen JK, et al.  (1992) Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product. J Biol Chem 267(10):6646-53	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-23	manually curated	Qin YM, et al.  (1999) Yeast peroxisomal multifunctional enzyme: (3R)-hydroxyacyl-CoA dehydrogenase domains A and B are required for optimal growth on oleic acid. J Biol Chem 274(40):28619-25	SGD
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00659 Last Updated 2013-03-02	computational	UniProt-GOA  (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
IDP3/YNL009W	IMP: Inferred from Mutant Phenotype Assigned on 2002-12-02	manually curated	Henke B, et al.  (1998) IDP3 encodes a peroxisomal NADP-dependent isocitrate dehydrogenase required for the beta-oxidation of unsaturated fatty acids. J Biol Chem 273(6):3702-11	SGD
MDH3/YDL078C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	McAlister-Henn L and Small WC  (1997) Molecular genetics of yeast TCA cycle isozymes. Prog Nucleic Acid Res Mol Biol 57:317-39	SGD
POT1/YIL160C	IMP: Inferred from Mutant Phenotype Assigned on 2011-03-30	manually curated	Marchesini S and Poirier Y  (2003) Futile cycling of intermediates of fatty acid biosynthesis toward peroxisomal beta-oxidation in Saccharomyces cerevisiae. J Biol Chem 278(35):32596-601	SGD
POX1/YGL205W	IMP: Inferred from Mutant Phenotype Assigned on 2011-03-30	manually curated	Marchesini S and Poirier Y  (2003) Futile cycling of intermediates of fatty acid biosynthesis toward peroxisomal beta-oxidation in Saccharomyces cerevisiae. J Biol Chem 278(35):32596-601	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002655 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
TES1/YJR019C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2009-10-19	manually curated	Ntamack AG, et al.  (2009) Oleate beta-oxidation in yeast involves thioesterase but not Yor180c protein that is not a dienoyl-CoA isomerase. Biochim Biophys Acta 1791(5):371-8	SGD

NOT: fatty acid beta-oxidation      2 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DCI1/YOR180C	IMP: Inferred from Mutant Phenotype Assigned on 2010-01-04	manually curated	Ntamack AG, et al.  (2009) Oleate beta-oxidation in yeast involves thioesterase but not Yor180c protein that is not a dienoyl-CoA isomerase. Biochim Biophys Acta 1791(5):371-8	SGD
EHD3/YDR036C	IMP: Inferred from Mutant Phenotype Assigned on 2006-10-19	manually curated	Hiltunen JK, et al.  (2003) The biochemistry of peroxisomal beta-oxidation in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 27(1):35-64	SGD

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