Ontology: Biological Process (GO:0006626)

Definition: The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein.

Synonyms: mitochondrial protein import; mitochondrial translocation; protein targeting to mitochondria; protein-mitochondrial targeting; protein import into mitochondrion

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term protein targeting to mitochondrion (9 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	protein targeting to mitochondrion	8
High-throughput	none	none
Computational (download data)	protein targeting to mitochondrion	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term protein targeting to mitochondrion or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

protein targeting to mitochondrion      9 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ECM10/YEL030W	IGI: Inferred from Genetic Interaction Assigned on 2002-08-08	manually curated	Baumann F, et al.  (2000) Ecm10, a novel hsp70 homolog in the mitochondrial matrix of the yeast Saccharomyces cerevisiae. FEBS Lett 487(2):307-12	SGD
HSP82/YPL240C	IPI: Inferred from Physical Interaction with SGD:TOM70 Assigned on 2009-08-07	manually curated	Young JC, et al.  (2003) Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell 112(1):41-50	SGD
MSP1/YGR028W	IGI: Inferred from Genetic Interaction Assigned on 2003-11-19	manually curated	Nakai M, et al.  (1993) Intramitochondrial protein sorting. Isolation and characterization of the yeast MSP1 gene which belongs to a novel family of putative ATPases. J Biol Chem 268(32):24262-9	SGD
SAM37/YMR060C	IEA: Inferred from Electronic Annotation with EBI:IPR019564 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SSA1/YAL005C	IMP: Inferred from Mutant Phenotype Assigned on 2006-02-27	manually curated	Becker J, et al.  (1996) Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo. Mol Cell Biol 16(8):4378-86	SGD
TOM5/YPR133W-A	IMP: Inferred from Mutant Phenotype Assigned on 2009-04-10	manually curated	Dietmeier K, et al.  (1997) Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature 388(6638):195-200	SGD
TOM70/YNL121C	IGI: Inferred from Genetic Interaction with SGD:TOM71 Assigned on 2013-03-21	manually curated	Kondo-Okamoto N, et al.  (2008) Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis. EMBO Rep 9(1):63-9	SGD
TOM71/YHR117W	IGI: Inferred from Genetic Interaction with SGD:TOM70 Assigned on 2013-03-21	manually curated	Kondo-Okamoto N, et al.  (2008) Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis. EMBO Rep 9(1):63-9	SGD
YDJ1/YNL064C	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-06	manually curated	Atencio DP and Yaffe MP  (1992) MAS5, a yeast homolog of DnaJ involved in mitochondrial protein import. Mol Cell Biol 12(1):283-91	SGD

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