Ontology: Biological Process (GO:0006607)

Definition: The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane.

Synonyms: NLS-bearing substrate transport from cytoplasm to nucleus; NLS-bearing substrate-nucleus import; NLS-bearing substrate import into cell nucleus

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term NLS-bearing substrate import into nucleus (12 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	NLS-bearing substrate import into nucleus	12
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term NLS-bearing substrate import into nucleus or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

NLS-bearing substrate import into nucleus      12 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CMD1/YBR109C	IMP: Inferred from Mutant Phenotype Assigned on 2008-10-17	manually curated	Hanover JA, et al.  (2007) The High Mobility Group Box Transcription Factor Nhp6Ap Enters the Nucleus by a Calmodulin-dependent, Ran-independent Pathway. J Biol Chem 282(46):33743-51	SGD
KAP123/YER110C	IMP: Inferred from Mutant Phenotype Assigned on 2012-02-22	manually curated	Mosammaparast N, et al.  (2002) Pathways mediating the nuclear import of histones H3 and H4 in yeast. J Biol Chem 277(1):862-8	SGD
NSP1/YJL041W	IGI: Inferred from Genetic Interaction with SGD:NUP100, SGD:NUP145 Assigned on 2011-05-25	manually curated	Strawn LA, et al.  (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206	SGD
NUP1/YOR098C	IMP: Inferred from Mutant Phenotype Assigned on 2011-05-23	manually curated	Solsbacher J, et al.  (2000) Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha. Mol Cell Biol 20(22):8468-79	SGD
	IGI: Inferred from Genetic Interaction with SGD:NUP159, SGD:NUP42, SGD:NUP2, SGD:NUP60 Assigned on 2011-05-25	manually curated	Strawn LA, et al.  (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-05-23	manually curated	Belanger KD, et al.  (2005) Nuclear pore complex function in Saccharomyces cerevisiae is influenced by glycosylation of the transmembrane nucleoporin Pom152p. Genetics 171(3):935-47	SGD
NUP100/YKL068W	IGI: Inferred from Genetic Interaction with SGD:NUP145, SGD:NUP57 Assigned on 2011-05-25	manually curated	Strawn LA, et al.  (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206	SGD
NUP145/YGL092W	IGI: Inferred from Genetic Interaction with SGD:NUP57, SGD:NUP100 Assigned on 2011-05-25	manually curated	Strawn LA, et al.  (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206	SGD
NUP159/YIL115C	IGI: Inferred from Genetic Interaction with SGD:NUP60, SGD:NUP42, SGD:NUP1, SGD:NUP2 Assigned on 2011-05-25	manually curated	Strawn LA, et al.  (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206	SGD
NUP2/YLR335W	IMP: Inferred from Mutant Phenotype Assigned on 2012-12-10	manually curated	Solsbacher J, et al.  (2000) Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha. Mol Cell Biol 20(22):8468-79	SGD
	IGI: Inferred from Genetic Interaction with SGD:NUP159, SGD:NUP42, SGD:NUP1, SGD:NUP60 Assigned on 2011-05-25	manually curated	Strawn LA, et al.  (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206	SGD
NUP42/YDR192C	IGI: Inferred from Genetic Interaction with SGD:NUP159, SGD:NUP1, SGD:NUP2, SGD:NUP60 Assigned on 2011-05-25	manually curated	Strawn LA, et al.  (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206	SGD
NUP53/YMR153W	IGI: Inferred from Genetic Interaction with SGD:KAP95, IMP: Inferred from Mutant Phenotype Assigned on 2011-05-23	manually curated	Fahrenkrog B, et al.  (2000) The yeast nucleoporin Nup53p specifically interacts with Nic96p and is directly involved in nuclear protein import. Mol Biol Cell 11(11):3885-96	SGD
NUP57/YGR119C	IGI: Inferred from Genetic Interaction with SGD:NUP100, SGD:NUP145 Assigned on 2011-05-25	manually curated	Strawn LA, et al.  (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206	SGD
NUP60/YAR002W	IMP: Inferred from Mutant Phenotype Assigned on 2011-05-25	manually curated	Denning D, et al.  (2001) The nucleoporin Nup60p functions as a Gsp1p-GTP-sensitive tether for Nup2p at the nuclear pore complex. J Cell Biol 154(5):937-50	SGD
	IGI: Inferred from Genetic Interaction with SGD:NUP159, SGD:NUP42, SGD:NUP1, SGD:NUP2 Assigned on 2011-05-25	manually curated	Strawn LA, et al.  (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206	SGD

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