Ontology: Biological Process (GO:0006513)

Definition: Addition of a single ubiquitin group to a protein.

Synonyms: protein monoubiquitinylation; protein monoubiquitylation

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term protein monoubiquitination (17 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	protein monoubiquitination	17
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term protein monoubiquitination or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

protein monoubiquitination      17 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
BUL1/YMR275C	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Yashiroda H, et al.  (1996) Bul1, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae. Mol Cell Biol 16(7):3255-63	SGD
BUL2/YML111W	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Yashiroda H, et al.  (1998) The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions. Gene 225(1-2):39-46	SGD
LGE1/YPL055C	IMP: Inferred from Mutant Phenotype Assigned on 2003-03-07	manually curated	Hwang WW, et al.  (2003) A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Mol Cell 11(1):261-6	SGD
MUB1/YMR100W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2008-06-27	manually curated	Ju D, et al.  (2008) Genome-wide analysis identifies MYND-domain protein Mub1 as an essential factor for Rpn4 ubiquitylation. Mol Cell Biol 28(4):1404-12	SGD
PEX4/YGR133W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-06-20	manually curated	Platta HW, et al.  (2007) Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling. J Cell Biol 177(2):197-204	SGD
RAD18/YCR066W	IMP: Inferred from Mutant Phenotype Assigned on 2009-11-11	manually curated	Hoege C, et al.  (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419(6903):135-41	SGD
RAD6/YGL058W	IMP: Inferred from Mutant Phenotype Assigned on 2009-11-11	manually curated	Hoege C, et al.  (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419(6903):135-41	SGD
RSP5/YER125W	IGI: Inferred from Genetic Interaction with SGD:RVS167, IMP: Inferred from Mutant Phenotype Assigned on 2008-10-13	manually curated	Stamenova SD, et al.  (2004) The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167. J Biol Chem 279(16):16017-25	SGD
	IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction with SGD:GPA1, IMP: Inferred from Mutant Phenotype Assigned on 2009-02-11	manually curated	Torres MP, et al.  (2009) G Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase. J Biol Chem 284(13):8940-50	SGD
UBC1/YDR177W	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Hochstrasser M  (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39	SGD
UBC11/YOR339C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Hochstrasser M  (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39	SGD
UBC13/YDR092W	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Hochstrasser M  (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39	SGD
UBC4/YBR082C	IDA: Inferred from Direct Assay Assigned on 2005-01-03	manually curated	Parag HA, et al.  (1993) Selective ubiquitination of calmodulin by UBC4 and a putative ubiquitin protein ligase (E3) from Saccharomyces cerevisiae. FEBS Lett 325(3):242-6	SGD
UBC6/YER100W	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Hochstrasser M  (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39	SGD
UBC8/YEL012W	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Hochstrasser M  (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39	SGD
UBI4/YLL039C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Hochstrasser M  (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39	SGD
UBR2/YLR024C	IDA: Inferred from Direct Assay Assigned on 2008-06-27	manually curated	Ju D, et al.  (2008) Genome-wide analysis identifies MYND-domain protein Mub1 as an essential factor for Rpn4 ubiquitylation. Mol Cell Biol 28(4):1404-12	SGD
UFD4/YKL010C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Hochstrasser M  (1996) Ubiquitin-dependent protein degradation. Annu Rev Genet 30:405-39	SGD

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