Ontology: Biological Process (GO:0006493)

Definition: A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.

Synonyms: protein amino acid O-linked glycosylation

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term protein O-linked glycosylation (15 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	protein O-linked glycosylation	13
High-throughput	none	none
Computational (download data)	protein O-linked glycosylation	6

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term protein O-linked glycosylation or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

protein O-linked glycosylation      15 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DPM1/YPR183W	IMP: Inferred from Mutant Phenotype Assigned on 2002-09-26	manually curated	Orlean P  (1992) Enzymes that recognize dolichols participate in three glycosylation pathways and are required for protein secretion. Biochem Cell Biol 70(6):438-47	SGD
KRE2/YDR483W	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Hausler A, et al.  (1992) Yeast glycoprotein biosynthesis: MNT1 encodes an alpha-1,2-mannosyltransferase involved in O-glycosylation. Proc Natl Acad Sci U S A 89(15):6846-50	SGD
KTR1/YOR099W	IGI: Inferred from Genetic Interaction with SGD:KRE2, SGD:KTR3 Assigned on 2010-06-28	manually curated	Lussier M, et al.  (1997) The Ktr1p, Ktr3p, and Kre2p/Mnt1p mannosyltransferases participate in the elaboration of yeast O- and N-linked carbohydrate chains. J Biol Chem 272(24):15527-31	SGD
KTR3/YBR205W	IGI: Inferred from Genetic Interaction with SGD:KTR1, SGD:KRE2 Assigned on 2010-06-28	manually curated	Lussier M, et al.  (1997) The Ktr1p, Ktr3p, and Kre2p/Mnt1p mannosyltransferases participate in the elaboration of yeast O- and N-linked carbohydrate chains. J Biol Chem 272(24):15527-31	SGD
MNN1/YER001W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Graham TR, et al.  (1994) Clathrin-dependent localization of alpha 1,3 mannosyltransferase to the Golgi complex of Saccharomyces cerevisiae. J Cell Biol 127(3):667-78	SGD
MNN4/YKL201C	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-13	manually curated	Nakayama K, et al.  (1998) The involvement of mnn4 and mnn6 mutations in mannosylphosphorylation of O-linked oligosaccharide in yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1425(1):255-62	SGD
MNT2/YGL257C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Romero PA, et al.  (1999) Mnt2p and Mnt3p of Saccharomyces cerevisiae are members of the Mnn1p family of alpha-1,3-mannosyltransferases responsible for adding the terminal mannose residues of O-linked oligosaccharides. Glycobiology 9(10):1045-51	SGD
MNT3/YIL014W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Romero PA, et al.  (1999) Mnt2p and Mnt3p of Saccharomyces cerevisiae are members of the Mnn1p family of alpha-1,3-mannosyltransferases responsible for adding the terminal mannose residues of O-linked oligosaccharides. Glycobiology 9(10):1045-51	SGD
MNT4/YNR059W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Romero PA, et al.  (1999) Mnt2p and Mnt3p of Saccharomyces cerevisiae are members of the Mnn1p family of alpha-1,3-mannosyltransferases responsible for adding the terminal mannose residues of O-linked oligosaccharides. Glycobiology 9(10):1045-51	SGD
PMT1/YDL095W	IEA: Inferred from Electronic Annotation with EBI:IPR003342 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PMT2/YAL023C	IMP: Inferred from Mutant Phenotype Assigned on 2012-08-24	manually curated	Gentzsch M and Tanner W  (1997) Protein-O-glycosylation in yeast: protein-specific mannosyltransferases. Glycobiology 7(4):481-6	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR003342 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PMT3/YOR321W	ISA: Inferred from Sequence Alignment with SGD:PMT1, SGD:PMT2 Assigned on 2012-08-23	manually curated	Immervoll T, et al.  (1995) PMT3 and PMT4, two new members of the protein-O-mannosyltransferase gene family of Saccharomyces cerevisiae. Yeast 11(14):1345-51	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR003342 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PMT4/YJR143C	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Immervoll T, et al.  (1995) PMT3 and PMT4, two new members of the protein-O-mannosyltransferase gene family of Saccharomyces cerevisiae. Yeast 11(14):1345-51	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR003342 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PMT5/YDL093W	IEA: Inferred from Electronic Annotation with EBI:IPR003342 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
PMT6/YGR199W	IMP: Inferred from Mutant Phenotype Assigned on 2011-04-01	manually curated	Gentzsch M and Tanner W  (1997) Protein-O-glycosylation in yeast: protein-specific mannosyltransferases. Glycobiology 7(4):481-6	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR003342 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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