GO term: protein complex assembly 
Ontology: Biological Process (GO:0006461)
Definition: The aggregation, arrangement and bonding together of a set of components to form a protein complex.
Synonyms: chaperone activity; protein complex formation
View Ontology:
(graph) | 
(text)
Definition: The aggregation, arrangement and bonding together of a set of components to form a protein complex.
Synonyms: chaperone activity; protein complex formation
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
protein complex assembly (28 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | protein complex assembly | 25 |
| High-throughput | none | none |
| Computational (download data) | protein complex assembly | 3 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
protein complex assembly or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| protein complex assembly 28 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AFG3/YER017C | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Arlt H, et al. (1996) The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria. Cell 85(6):875-85 |
SGD |
| ATG34/YOL083W | IMP: Inferred from Mutant Phenotype Assigned on 2010-08-05 |
manually curated | Suzuki K, et al. (2010) Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p. J Biol Chem 285(39):30019-25 |
SGD |
| ATP11/YNL315C | IEA: Inferred from Electronic Annotation with EBI:IPR010591 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| ATP20/YPR020W | IMP: Inferred from Mutant Phenotype Assigned on 2007-09-18 |
manually curated | Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906 |
SGD |
| ATP22/YDR350C | IEA: Inferred from Electronic Annotation with EBI:IPR017207 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| ATP7/YKL016C | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2003-07-11 |
manually curated | Norais N, et al. (1991) ATP synthase of yeast mitochondria. Characterization of subunit d and sequence analysis of the structural gene ATP7. J Biol Chem 266(25):16541-9 |
SGD |
| COX11/YPL132W | IMP: Inferred from Mutant Phenotype Assigned on 2004-02-06 |
manually curated | Tzagoloff A, et al. (1990) Cytochrome oxidase assembly in yeast requires the product of COX11, a homolog of the P. denitrificans protein encoded by ORF3. EMBO J 9(9):2759-64 |
SGD |
| MDN1/YLR106C | IEA: Inferred from Electronic Annotation with EBI:IPR012099 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| OST3/YOR085W | IMP: Inferred from Mutant Phenotype Assigned on 2002-11-04 |
manually curated | Knauer R and Lehle L (1999) The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex. J Biol Chem 274(24):17249-56 |
SGD |
| OST6/YML019W | IMP: Inferred from Mutant Phenotype Assigned on 2002-11-04 |
manually curated | Knauer R and Lehle L (1999) The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex. J Biol Chem 274(24):17249-56 |
SGD |
| PNO1/YOR145C | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2003-03-11 |
manually curated | Tone Y and Toh-E A (2002) Nob1p is required for biogenesis of the 26S proteasome and degraded upon its maturation in Saccharomyces cerevisiae. Genes Dev 16(24):3142-57 |
SGD |
| SAM50/YNL026W | IMP: Inferred from Mutant Phenotype Assigned on 2004-03-03 |
manually curated | Kozjak V, et al. (2003) An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. J Biol Chem 278(49):48520-3 |
SGD |
| IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2004-03-10 |
manually curated | Paschen SA, et al. (2003) Evolutionary conservation of biogenesis of beta-barrel membrane proteins. Nature 426(6968):862-6 |
SGD | |
| SCO1/YBR037C | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Schulze M and Rodel G (1988) SCO1, a yeast nuclear gene essential for accumulation of mitochondrial cytochrome c oxidase subunit II. Mol Gen Genet 211(3):492-8 |
SGD |
| SGF73/YGL066W | IMP: Inferred from Mutant Phenotype Assigned on 2010-12-14 |
manually curated | Lee KK, et al. (2009) Yeast Sgf73/Ataxin-7 serves to anchor the deubiquitination module into both SAGA and Slik(SALSA) HAT complexes. Epigenetics Chromatin 2(1):2 |
SGD |
| SGT1/YOR057W | IGI: Inferred from Genetic Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2003-01-08 |
manually curated | Dubacq C, et al. (2002) Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Eukaryot Cell 1(4):568-82 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2004-09-04 |
manually curated | Rodrigo-Brenni MC, et al. (2004) Sgt1p and Skp1p modulate the assembly and turnover of CBF3 complexes required for proper kinetochore function. Mol Biol Cell 15(7):3366-78 |
SGD | |
| SKI8/YGL213C | IMP: Inferred from Mutant Phenotype Assigned on 2009-03-06 |
manually curated | Arora C, et al. (2004) Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol Cell 13(4):549-59 |
SGD |
| SKP1/YDR328C | IDA: Inferred from Direct Assay Assigned on 2004-09-04 |
manually curated | Rodrigo-Brenni MC, et al. (2004) Sgt1p and Skp1p modulate the assembly and turnover of CBF3 complexes required for proper kinetochore function. Mol Biol Cell 15(7):3366-78 |
SGD |
| SPT7/YBR081C | IMP: Inferred from Mutant Phenotype Assigned on 2003-06-09 |
manually curated | Wu PY and Winston F (2002) Analysis of Spt7 function in the Saccharomyces cerevisiae SAGA coactivator complex. Mol Cell Biol 22(15):5367-79 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2003-06-09 |
manually curated | Sterner DE, et al. (1999) Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction. Mol Cell Biol 19(1):86-98 |
SGD | |
| SSP1/YHR184W | IMP: Inferred from Mutant Phenotype Assigned on 2002-09-20 |
manually curated | Moreno-Borchart AC, et al. (2001) Prospore membrane formation linked to the leading edge protein (LEP) coat assembly. EMBO J 20(24):6946-57 |
SGD |
| TAZ1/YPR140W | IMP: Inferred from Mutant Phenotype Assigned on 2006-11-15 |
manually curated | Brandner K, et al. (2005) Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome. Mol Biol Cell 16(11):5202-14 |
SGD |
| TCA17/YEL048C | IMP: Inferred from Mutant Phenotype Assigned on 2011-04-12 |
manually curated | Choi C, et al. (2011) Organization and assembly of the TRAPPII complex. Traffic 12(6):715-25 |
SGD |
| TRS33/YOR115C | IGI: Inferred from Genetic Interaction with SGD:TRS130 Assigned on 2010-12-10 |
manually curated | Tokarev AA, et al. (2009) TRAPP II Complex Assembly Requires Trs33 or Trs65. Traffic 10(12):1831-44 |
SGD |
| TRS65/YGR166W | IGI: Inferred from Genetic Interaction with SGD:TRS120, SGD:TRS130 Assigned on 2010-12-10 |
manually curated | Liang Y, et al. (2007) The role of Trs65 in the Ypt/Rab guanine nucleotide exchange factor function of the TRAPP II complex. Mol Biol Cell 18(7):2533-41 |
SGD |
| VMA9/YCL005W-A | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:VMA21 Assigned on 2006-10-18 |
manually curated | Compton MA, et al. (2006) Vma9p (subunit e) is an integral membrane V0 subunit of the yeast V-ATPase. J Biol Chem 281(22):15312-9 |
SGD |
| VOA1/YGR106C | IMP: Inferred from Mutant Phenotype Assigned on 2008-12-02 |
manually curated | Ryan M, et al. (2008) Voa1p functions in V-ATPase assembly in the yeast endoplasmic reticulum. Mol Biol Cell 19(12):5131-42 |
SGD |
| VPH1/YOR270C | IMP: Inferred from Mutant Phenotype Assigned on 2006-10-19 |
manually curated | Leng XH, et al. (1996) Site-directed mutagenesis of the 100-kDa subunit (Vph1p) of the yeast vacuolar (H+)-ATPase. J Biol Chem 271(37):22487-93 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2006-10-19 |
manually curated | Manolson MF, et al. (1992) The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase. J Biol Chem 267(20):14294-303 |
SGD | |
| YPT1/YFL038C | IDA: Inferred from Direct Assay Assigned on 2002-07-31 |
manually curated | Sapperstein SK, et al. (1996) Assembly of the ER to Golgi SNARE complex requires Uso1p. J Cell Biol 132(5):755-67 |
SGD |
| YTA12/YMR089C | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Arlt H, et al. (1996) The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondria. Cell 85(6):875-85 |
SGD |
