Ontology: Biological Process (GO:0006457)

Definition: The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Synonyms: chaperone activity; chaperonin ATPase activity; co-chaperone activity; co-chaperonin activity; glycoprotein-specific chaperone activity; non-chaperonin molecular chaperone ATPase activity; protein complex assembly, multichaperone pathway; alpha-tubulin folding; beta-tubulin folding; chaperonin-mediated tubulin folding

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term protein folding (94 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	protein folding	64
High-throughput	none	none
Computational (download data)	protein folding	48

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term protein folding or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

protein folding      94 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
AHA1/YDR214W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:HSP82 Assigned on 2003-01-07	manually curated	Panaretou B, et al.  (2002) Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Mol Cell 10(6):1307-18	SGD
ALF1/YNL148C	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Feierbach B, et al.  (1999) Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin. J Cell Biol 144(1):113-24	SGD
APJ1/YNL077W	IEA: Inferred from Electronic Annotation with EBI:IPR002939, EBI:IPR008971 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BTN2/YGR142W	IGI: Inferred from Genetic Interaction with SGD:SIS1, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:SIS1 Assigned on 2012-12-03	manually curated	Malinovska L, et al.  (2012) Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates. Mol Biol Cell 23(16):3041-56	SGD
BUD27/YFL023W	IEA: Inferred from Electronic Annotation with EBI:IPR004127 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CAJ1/YER048C	ISS: Inferred from Sequence or structural Similarity with EBI:P08622 Assigned on 2009-03-04	manually curated	Mukai H, et al.  (1994) Isolation and characterization of CAJ1, a novel yeast homolog of dnaJ. Gene 145(1):125-7	SGD
CCT2/YIL142W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR012716, EBI:IPR002194 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT3/YJL014W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR012719, EBI:IPR002194 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT4/YDL143W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR012717, EBI:IPR002194 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT5/YJR064W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR012718, EBI:IPR002194 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT6/YDR188W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR012722, EBI:IPR002194 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT7/YJL111W	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR012720, EBI:IPR002194 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CCT8/YJL008C	IDA: Inferred from Direct Assay Assigned on 2009-06-16	manually curated	Pappenberger G, et al.  (2006) Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit. J Mol Biol 360(2):484-96	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR012721, EBI:IPR002194 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CHS7/YHR142W	IMP: Inferred from Mutant Phenotype Assigned on 2005-07-08	manually curated	Kota J and Ljungdahl PO  (2005) Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. J Cell Biol 168(1):79-88	SGD
CIN1/YOR349W	IGI: Inferred from Genetic Interaction with SGD:TUB2 Assigned on 2010-10-14	manually curated	Stearns T, et al.  (1990) Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124(2):251-62	SGD
	ISS: Inferred from Sequence or structural Similarity with GenBank/EMBL/DDBJ:AAB17537 Assigned on 2010-10-14	manually curated	Hoyt MA, et al.  (1997) Saccharomyces cerevisiae PAC2 functions with CIN1, 2 and 4 in a pathway leading to normal microtubule stability. Genetics 146(3):849-57	SGD
CIN2/YPL241C	IGI: Inferred from Genetic Interaction with SGD:TUB1 Assigned on 2010-10-14	manually curated	Stearns T, et al.  (1990) Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124(2):251-62	SGD
CIN4/YMR138W	IGI: Inferred from Genetic Interaction with SGD:TUB2 Assigned on 2010-10-14	manually curated	Stearns T, et al.  (1990) Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124(2):251-62	SGD
CNE1/YAL058W	IMP: Inferred from Mutant Phenotype Assigned on 2005-05-03	manually curated	Xu X, et al.  (2004) Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue. J Biochem 135(5):615-8	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001580 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CNS1/YBR155W	IPI: Inferred from Physical Interaction with SGD:HSP82, SGD:SSA1 Assigned on 2005-05-09	manually curated	Hainzl O, et al.  (2004) Cns1 is an activator of the Ssa1 ATPase activity. J Biol Chem 279(22):23267-73	SGD
	IGI: Inferred from Genetic Interaction Assigned on 2002-10-09	manually curated	Dolinski KJ, et al.  (1998) CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90. Mol Cell Biol 18(12):7344-52	SGD
CPR1/YDR155C	IEA: Inferred from Electronic Annotation with EBI:IPR002130, EBI:IPR020892, EBI:IPR024936 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0697 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CPR2/YHR057C	IEA: Inferred from Electronic Annotation with EBI:IPR002130, EBI:IPR020892, EBI:IPR024936 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0697 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CPR3/YML078W	IDA: Inferred from Direct Assay Assigned on 2002-12-02	manually curated	Matouschek A, et al.  (1995) Cyclophilin catalyzes protein folding in yeast mitochondria. Proc Natl Acad Sci U S A 92(14):6319-23	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR020892, EBI:IPR024936, EBI:IPR002130 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0697 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CPR4/YCR069W	IEA: Inferred from Electronic Annotation with EBI:IPR002130 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0697 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CPR5/YDR304C	IEA: Inferred from Electronic Annotation with EBI:IPR020892, EBI:IPR024936, EBI:IPR002130 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0697 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CPR6/YLR216C	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Prodromou C, et al.  (1999) Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO J 18(3):754-62	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002130, EBI:IPR020892 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0697 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CPR7/YJR032W	IEA: Inferred from Electronic Annotation with EBI:IPR020892, EBI:IPR002130 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0697 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CPR8/YNR028W	IEA: Inferred from Electronic Annotation with EBI:IPR002130 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0697 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
CUR1/YPR158W	IGI: Inferred from Genetic Interaction with SGD:SIS1, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:SIS1 Assigned on 2012-12-03	manually curated	Malinovska L, et al.  (2012) Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates. Mol Biol Cell 23(16):3041-56	SGD
CWC27/YPL064C	IEA: Inferred from Electronic Annotation with EBI:IPR002130 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0697 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ECM10/YEL030W	IEA: Inferred from Electronic Annotation with EBI:IPR012725 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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