Ontology: Biological Process (GO:0006450)

Definition: Any process that modulates the ability of the translational apparatus to interpret the genetic code.

Synonyms: regulation of translational accuracy

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term regulation of translational fidelity (18 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	regulation of translational fidelity	12
High-throughput	none	none
Computational (download data)	regulation of translational fidelity	6

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term regulation of translational fidelity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

regulation of translational fidelity      18 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CDC60/YPL160W	IEA: Inferred from Electronic Annotation with EBI:IPR009008 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	GOC
ILS1/YBL076C	IEA: Inferred from Electronic Annotation with EBI:IPR009008 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	GOC
ISM1/YPL040C	IEA: Inferred from Electronic Annotation with EBI:IPR009008 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	GOC
NAM2/YLR382C	IEA: Inferred from Electronic Annotation with EBI:IPR009008, EBI:IPR025709 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	GOC
RDN25-1	IMP: Inferred from Mutant Phenotype Assigned on 2007-05-23	manually curated	Liu R and Liebman SW  (1996) A translational fidelity mutation in the universally conserved sarcin/ricin domain of 25S yeast ribosomal RNA. RNA 2(3):254-63	SGD
RDN25-2	IMP: Inferred from Mutant Phenotype Assigned on 2007-05-23	manually curated	Liu R and Liebman SW  (1996) A translational fidelity mutation in the universally conserved sarcin/ricin domain of 25S yeast ribosomal RNA. RNA 2(3):254-63	SGD
RPL31A/YDL075W	IMP: Inferred from Mutant Phenotype Assigned on 2008-10-15	manually curated	Peisker K, et al.  (2008) Ribosome-associated complex binds to ribosomes in close proximity of Rpl31 at the exit of the polypeptide tunnel in yeast. Mol Biol Cell 19(12):5279-88	SGD
RPL31B/YLR406C	IMP: Inferred from Mutant Phenotype Assigned on 2008-10-15	manually curated	Peisker K, et al.  (2008) Ribosome-associated complex binds to ribosomes in close proximity of Rpl31 at the exit of the polypeptide tunnel in yeast. Mol Biol Cell 19(12):5279-88	SGD
RPS23A/YGR118W	IGI: Inferred from Genetic Interaction with SGD:RPS9B, SGD:RPS2, IMP: Inferred from Mutant Phenotype Assigned on 2008-09-17	manually curated	Anthony RA and Liebman SW  (1995) Alterations in ribosomal protein RPS28 can diversely affect translational accuracy in Saccharomyces cerevisiae. Genetics 140(4):1247-58	SGD
	IGI: Inferred from Genetic Interaction with SGD:RPS23B, SGD:RPS2, IMP: Inferred from Mutant Phenotype Assigned on 2000-10-02	manually curated	Synetos D, et al.  (1996) Mutations in yeast ribosomal proteins S28 and S4 affect the accuracy of translation and alter the sensitivity of the ribosomes to paromomycin. Biochim Biophys Acta 1309(1-2):156-66	SGD
	IGI: Inferred from Genetic Interaction with SGD:RPS23B, SGD:RPS2, IMP: Inferred from Mutant Phenotype Assigned on 2008-09-17	manually curated	Alksne LE, et al.  (1993) An accuracy center in the ribosome conserved over 2 billion years. Proc Natl Acad Sci U S A 90(20):9538-41	SGD
RPS23B/YPR132W	IGI: Inferred from Genetic Interaction with SGD:RPS23A, SGD:RPS2, IMP: Inferred from Mutant Phenotype Assigned on 2000-10-02	manually curated	Synetos D, et al.  (1996) Mutations in yeast ribosomal proteins S28 and S4 affect the accuracy of translation and alter the sensitivity of the ribosomes to paromomycin. Biochim Biophys Acta 1309(1-2):156-66	SGD
	IGI: Inferred from Genetic Interaction with SGD:RPS23A, SGD:RPS2, IMP: Inferred from Mutant Phenotype Assigned on 2008-09-17	manually curated	Alksne LE, et al.  (1993) An accuracy center in the ribosome conserved over 2 billion years. Proc Natl Acad Sci U S A 90(20):9538-41	SGD
RPS5/YJR123W	ISA: Inferred from Sequence Alignment with EBI:P46782 Assigned on 2008-12-03	manually curated	Galkin O, et al.  (2007) Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5. RNA 13(12):2116-2128	SGD
SSB1/YDL229W	IMP: Inferred from Mutant Phenotype Assigned on 2006-01-24	manually curated	Rakwalska M and Rospert S  (2004) The ribosome-bound chaperones RAC and Ssb1/2p are required for accurate translation in Saccharomyces cerevisiae. Mol Cell Biol 24(20):9186-97	SGD
SSB2/YNL209W	IMP: Inferred from Mutant Phenotype Assigned on 2006-01-24	manually curated	Rakwalska M and Rospert S  (2004) The ribosome-bound chaperones RAC and Ssb1/2p are required for accurate translation in Saccharomyces cerevisiae. Mol Cell Biol 24(20):9186-97	SGD
SSZ1/YHR064C	IMP: Inferred from Mutant Phenotype Assigned on 2006-01-24	manually curated	Rakwalska M and Rospert S  (2004) The ribosome-bound chaperones RAC and Ssb1/2p are required for accurate translation in Saccharomyces cerevisiae. Mol Cell Biol 24(20):9186-97	SGD
SUA5/YGL169W	IMP: Inferred from Mutant Phenotype Assigned on 2010-11-29	manually curated	Lin CA, et al.  (2010) The sua5 protein is essential for normal translational regulation in yeast. Mol Cell Biol 30(1):354-63	SGD
VAS1/YGR094W	IEA: Inferred from Electronic Annotation with EBI:IPR009008 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	GOC
YHR020W	IEA: Inferred from Electronic Annotation with EBI:IPR007214 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	GOC
ZUO1/YGR285C	IMP: Inferred from Mutant Phenotype Assigned on 2006-01-24	manually curated	Rakwalska M and Rospert S  (2004) The ribosome-bound chaperones RAC and Ssb1/2p are required for accurate translation in Saccharomyces cerevisiae. Mol Cell Biol 24(20):9186-97	SGD

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