GO term: translational initiation 
Ontology: Biological Process (GO:0006413)
Definition: The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
Synonyms: biopolymerisation; biopolymerization; protein synthesis initiation; translation initiation
View Ontology:
(graph) | 
(text)
Definition: The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
Synonyms: biopolymerisation; biopolymerization; protein synthesis initiation; translation initiation
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
translational initiation (48 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | translational initiation | 32 |
| High-throughput | none | none |
| Computational (download data) | translational initiation | 36 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
translational initiation or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| translational initiation 48 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| CAF20/YOR276W | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| CDC33/YOL139C | TAS: Traceable Author Statement Assigned on 2001-01-24 |
manually curated | McCarthy JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev 62(4):1492-553 |
SGD |
| ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Brenner C, et al. (1988) CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiae. Mol Cell Biol 8(8):3556-9 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR001040, EBI:IPR019770 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| CLU1/YMR012W | IPI: Inferred from Physical Interaction Assigned on 2003-04-23 |
manually curated | Vornlocher HP, et al. (1999) A 110-kilodalton subunit of translation initiation factor eIF3 and an associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes. J Biol Chem 274(24):16802-12 |
SGD |
| DBP1/YPL119C | IMP: Inferred from Mutant Phenotype Assigned on 2004-08-11 |
manually curated | Berthelot K, et al. (2004) Dynamics and processivity of 40S ribosome scanning on mRNA in yeast. Mol Microbiol 51(4):987-1001 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| DED1/YOR204W | IMP: Inferred from Mutant Phenotype Assigned on 2002-11-12 |
manually curated | Chuang RY, et al. (1997) Requirement of the DEAD-Box protein ded1p for messenger RNA translation. Science 275(5305):1468-71 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2004-08-11 |
manually curated | Berthelot K, et al. (2004) Dynamics and processivity of 40S ribosome scanning on mRNA in yeast. Mol Microbiol 51(4):987-1001 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| FMT1/YBL013W | IEA: Inferred from Electronic Annotation with EBI:IPR005794 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
GOC |
| IEA: Inferred from Electronic Annotation with IUBMB:2.1.2.9 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
GOC | |
| FUN12/YAL035W | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| GCD1/YOR260W | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| GCD10/YNL062C | IEA: Inferred from Electronic Annotation with EBI:IPR017423, EBI:IPR007316 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| GCD11/YER025W | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| GCD2/YGR083C | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| GCD6/YDR211W | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| GCD7/YLR291C | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| GCN3/YKR026C | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| HCR1/YLR192C | IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IFM1/YOL023W | ISA: Inferred from Sequence Alignment with GenBank/EMBL/DDBJ:ACB04247.1 Assigned on 2008-11-20 |
manually curated | Vambutas A, et al. (1991) Mitochondrial translational-initiation and elongation factors in Saccharomyces cerevisiae. Eur J Biochem 201(3):643-52 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR006847, EBI:IPR000178 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IMT1/tM(CAU)O1 | NAS: Non-traceable Author Statement Assigned on 2003-05-07 |
manually curated | Percudani R, et al. (1997) Transfer RNA gene redundancy and translational selection in Saccharomyces cerevisiae. J Mol Biol 268(2):322-30 |
SGD |
| IMT2/tM(CAU)P | NAS: Non-traceable Author Statement Assigned on 2003-05-07 |
manually curated | Percudani R, et al. (1997) Transfer RNA gene redundancy and translational selection in Saccharomyces cerevisiae. J Mol Biol 268(2):322-30 |
SGD |
| IMT3/tM(CAU)J3 | NAS: Non-traceable Author Statement Assigned on 2003-05-07 |
manually curated | Percudani R, et al. (1997) Transfer RNA gene redundancy and translational selection in Saccharomyces cerevisiae. J Mol Biol 268(2):322-30 |
SGD |
| IMT4/tM(CAU)E | NAS: Non-traceable Author Statement Assigned on 2003-05-07 |
manually curated | Percudani R, et al. (1997) Transfer RNA gene redundancy and translational selection in Saccharomyces cerevisiae. J Mol Biol 268(2):322-30 |
SGD |
| LTO1/YNL260C | IMP: Inferred from Mutant Phenotype Assigned on 2013-01-22 |
manually curated | Zhai C, et al. (2013) The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome.LID - 10.1038/onc.2012.604 [doi] Oncogene () |
SGD |
| NIP1/YMR309C | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-01-16 |
manually curated | Greenberg JR, et al. (1998) Nip1p associates with 40 S ribosomes and the Prt1p subunit of eukaryotic initiation factor 3 and is required for efficient translation initiation. J Biol Chem 273(36):23485-94 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2002-01-16 |
manually curated | Phan L, et al. (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18(8):4935-46 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR008905 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| PET122/YER153C | IEA: Inferred from Electronic Annotation with EBI:IPR008732 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| PRT1/YOR361C | IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18 |
manually curated | Hanic-Joyce PJ, et al. (1987) Molecular characterization of the yeast PRT1 gene in which mutations affect translation initiation and regulation of cell proliferation. J Biol Chem 262(6):2845-51 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2002-01-16 |
manually curated | Phan L, et al. (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18(8):4935-46 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR011400 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| RLI1/YDR091C | IMP: Inferred from Mutant Phenotype Assigned on 2005-02-17 |
manually curated | Dong J, et al. (2004) The essential ATP-binding cassette protein RLI1 functions in translation by promoting preinitiation complex assembly. J Biol Chem 279(40):42157-68 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2005-04-04 |
manually curated | Kispal G, et al. (2005) Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J 24(3):589-98 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| RMD9/YGL107C | IGI: Inferred from Genetic Interaction with SGD:RSM28 Assigned on 2007-06-11 |
manually curated | Williams EH, et al. (2007) Translation initiation in Saccharomyces cerevisiae mitochondria: functional interactions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p. Genetics 175(3):1117-26 |
SGD |
| RPG1/YBR079C | IDA: Inferred from Direct Assay Assigned on 2002-01-16 |
manually curated | Phan L, et al. (1998) Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5. Mol Cell Biol 18(8):4935-46 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0396 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| RSM28/YDR494W | IGI: Inferred from Genetic Interaction Assigned on 2005-03-01 |
manually curated | Williams EH, et al. (2005) Alteration of a novel dispensable mitochondrial ribosomal small-subunit protein, Rsm28p, allows translation of defective COX2 mRNAs. Eukaryot Cell 4(2):337-45 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:IFM1, SGD:FMT1 Assigned on 2007-06-11 |
manually curated | Williams EH, et al. (2007) Translation initiation in Saccharomyces cerevisiae mitochondria: functional interactions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p. Genetics 175(3):1117-26 |
SGD | |
| SIS1/YNL007C | IMP: Inferred from Mutant Phenotype Assigned on 2002-10-01 |
manually curated | Zhong T and Arndt KT (1993) The yeast SIS1 protein, a DnaJ homolog, is required for the initiation of translation. Cell 73(6):1175-86 |
SGD |
| SUI1/YNL244C | TAS: Traceable Author Statement Assigned on 2001-01-24 |
manually curated | McCarthy JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev 62(4):1492-553 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR001950 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
