Ontology: Biological Process (GO:0006406)

Definition: The directed movement of mRNA from the nucleus to the cytoplasm.

Synonyms: mRNA export out of nucleus; mRNA transport from nucleus to cytoplasm; mRNA-nucleus export; mRNA export from cell nucleus

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term mRNA export from nucleus (34 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	mRNA export from nucleus	34
High-throughput (download data)	mRNA export from nucleus	1
Computational (download data)	mRNA export from nucleus	3

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term mRNA export from nucleus or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

mRNA export from nucleus      34 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
APQ12/YIL040W	IMP: Inferred from Mutant Phenotype Assigned on 2004-10-05	manually curated	Baker KE, et al.  (2004) The yeast Apq12 protein affects nucleocytoplasmic mRNA transport. RNA 10(9):1352-8	SGD
BRL1/YHR036W	IMP: Inferred from Mutant Phenotype Assigned on 2005-08-10	manually curated	Saitoh Yh, et al.  (2005) Brl1p -- a novel nuclear envelope protein required for nuclear transport. Traffic 6(6):502-17	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR018767 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BRR6/YGL247W	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-01	manually curated	de Bruyn Kops A and Guthrie C  (2001) An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport. EMBO J 20(15):4183-93	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR018767 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BUD13/YGL174W	IMP: Inferred from Mutant Phenotype Assigned on 2005-10-06	manually curated	Dziembowski A, et al.  (2004) Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing. EMBO J 23(24):4847-56	SGD
CRM1/YGR218W	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-07	manually curated	Stade K, et al.  (1997) Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90(6):1041-50	SGD
DBP5/YOR046C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-09-30	manually curated	Snay-Hodge CA, et al.  (1998) Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export. EMBO J 17(9):2663-76	SGD
GFD1/YMR255W	IGI: Inferred from Genetic Interaction Assigned on 2001-01-18	manually curated	Strahm Y, et al.  (1999) The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p. EMBO J 18(20):5761-77	SGD
	IGI: Inferred from Genetic Interaction Assigned on 2001-01-18	manually curated	Hodge CA, et al.  (1999) Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells. EMBO J 18(20):5778-88	SGD
GLE1/YDL207W	IMP: Inferred from Mutant Phenotype Assigned on 2010-10-26	manually curated	Alcazar-Roman AR, et al.  (2010) Control of mRNA export and translation termination by inositol hexakisphosphate requires specific interaction with Gle1. J Biol Chem 285(22):16683-92	SGD
HMT1/YBR034C	IGI: Inferred from Genetic Interaction Assigned on 2002-07-26	manually curated	Henry MF and Silver PA  (1996) A novel methyltransferase (Hmt1p) modifies poly(A)+-RNA-binding proteins. Mol Cell Biol 16(7):3668-78	SGD
	IGI: Inferred from Genetic Interaction Assigned on 2002-07-26	manually curated	Yun CY and Fu XD  (2000) Conserved SR protein kinase functions in nuclear import and its action is counteracted by arginine methylation in Saccharomyces cerevisiae. J Cell Biol 150(4):707-18	SGD
HPR1/YDR138W	IMP: Inferred from Mutant Phenotype Assigned on 2003-02-14	manually curated	Strasser K, et al.  (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417(6886):304-8	SGD
	IGI: Inferred from Genetic Interaction Assigned on 2003-01-07	manually curated	Zenklusen D, et al.  (2002) Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p. Mol Cell Biol 22(23):8241-53	SGD
IST3/YIR005W	IMP: Inferred from Mutant Phenotype Assigned on 2005-10-06	manually curated	Dziembowski A, et al.  (2004) Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing. EMBO J 23(24):4847-56	SGD
MEX67/YPL169C	IMP: Inferred from Mutant Phenotype Assigned on 2002-09-30	manually curated	Hurt E, et al.  (2000) Mex67p mediates nuclear export of a variety of RNA polymerase II transcripts. J Biol Chem 275(12):8361-8	SGD
MFT1/YML062C	IMP: Inferred from Mutant Phenotype Assigned on 2003-02-14	manually curated	Strasser K, et al.  (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417(6886):304-8	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR027186 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MIP6/YHR015W	IPI: Inferred from Physical Interaction Assigned on 2002-08-20	manually curated	Segref A, et al.  (1997) Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J 16(11):3256-71	SGD
NPL3/YDR432W	IGI: Inferred from Genetic Interaction Assigned on 2002-03-04	manually curated	Lei EP, et al.  (2001) Messenger RNAs are recruited for nuclear export during transcription. Genes Dev 15(14):1771-82	SGD
NUP100/YKL068W	IPI: Inferred from Physical Interaction with SGD:MEX67 Assigned on 2011-05-23	manually curated	Strawn LA, et al.  (2001) The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex. J Biol Chem 276(9):6445-52	SGD
NUP116/YMR047C	IPI: Inferred from Physical Interaction with SGD:MEX67 Assigned on 2011-05-23	manually curated	Strawn LA, et al.  (2001) The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex. J Biol Chem 276(9):6445-52	SGD
NUP120/YKL057C	IMP: Inferred from Mutant Phenotype Assigned on 2012-06-07	manually curated	Heath CV, et al.  (1995) Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene. J Cell Biol 131(6 Pt 2):1677-97	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2012-06-07	manually curated	Aitchison JD, et al.  (1995) Nup120p: a yeast nucleoporin required for NPC distribution and mRNA transport. J Cell Biol 131(6 Pt 2):1659-75	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2012-06-07	manually curated	Siniossoglou S, et al.  (1996) A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Cell 84(2):265-75	SGD
NUP82/YJL061W	IMP: Inferred from Mutant Phenotype Assigned on 2011-04-06	manually curated	Grandi P, et al.  (1995) A novel nuclear pore protein Nup82p which specifically binds to a fraction of Nsp1p. J Cell Biol 130(6):1263-73	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-04-06	manually curated	Hurwitz ME and Blobel G  (1995) NUP82 is an essential yeast nucleoporin required for poly(A)+ RNA export. J Cell Biol 130(6):1275-81	SGD
NUP84/YDL116W	IMP: Inferred from Mutant Phenotype Assigned on 2012-06-07	manually curated	Siniossoglou S, et al.  (1996) A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Cell 84(2):265-75	SGD
NUP85/YJR042W	IMP: Inferred from Mutant Phenotype Assigned on 2012-06-11	manually curated	Goldstein AL, et al.  (1996) Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p. Mol Biol Cell 7(6):917-34	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2012-06-07	manually curated	Siniossoglou S, et al.  (1996) A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Cell 84(2):265-75	SGD
PML1/YLR016C	IMP: Inferred from Mutant Phenotype Assigned on 2005-10-06	manually curated	Dziembowski A, et al.  (2004) Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing. EMBO J 23(24):4847-56	SGD
PSE1/YMR308C	IGI: Inferred from Genetic Interaction with SGD:KAP123 Assigned on 2009-10-20	manually curated	Seedorf M and Silver PA  (1997) Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A 94(16):8590-5	SGD
SAC3/YDR159W	IMP: Inferred from Mutant Phenotype Assigned on 2009-01-23	manually curated	Fischer T, et al.  (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52	SGD
	IGI: Inferred from Genetic Interaction with SGD:MTR2, SGD:MEX67, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:MTR2, SGD:MEX67, SGD:DBP5, SGD:NUP116, SGD:NSP1 Assigned on 2003-07-09	manually curated	Lei EP, et al.  (2003) Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell 14(3):836-47	SGD
SEM1/YDR363W-A	IGI: Inferred from Genetic Interaction with SGD:SAC3, SGD:THP1, SGD:MEX67, SGD:APQ12, SGD:DBP5, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:SAC3, SGD:THP1 Assigned on 2009-01-23	manually curated, high-throughput	Wilmes GM, et al.  (2008) A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell 32(5):735-46	SGD
SGF73/YGL066W	IMP: Inferred from Mutant Phenotype Assigned on 2011-01-27	manually curated	Kohler A, et al.  (2008) Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export. Nat Cell Biol 10(6):707-15	SGD
SUB2/YDL084W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2002-02-13	manually curated	Jensen TH, et al.  (2001) The DECD box putative ATPase Sub2p is an early mRNA export factor. Curr Biol 11(21):1711-5	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-02-13	manually curated	Strasser K and Hurt E  (2001) Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature 413(6856):648-52	SGD
SXM1/YDR395W	IGI: Inferred from Genetic Interaction Assigned on 2002-06-24	manually curated	Seedorf M and Silver PA  (1997) Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc Natl Acad Sci U S A 94(16):8590-5	SGD
TEX1/YNL253W	IC: Inferred By Curator from transcription export complex Assigned on 2003-02-21	manually curated	Strasser K, et al.  (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417(6886):304-8	SGD
THO2/YNL139C	IMP: Inferred from Mutant Phenotype Assigned on 2003-02-14	manually curated	Strasser K, et al.  (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417(6886):304-8	SGD

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