GO term: mRNA cleavage 
Ontology: Biological Process (GO:0006379)
Definition: Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
Synonyms: cleavage and polyadenylylation specificity factor activity; cleavage stimulation factor activity; pre-mRNA cleavage factor activity
View Ontology:
(graph) | 
(text)
Definition: Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
Synonyms: cleavage and polyadenylylation specificity factor activity; cleavage stimulation factor activity; pre-mRNA cleavage factor activity
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
mRNA cleavage (28 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | mRNA cleavage | 28 |
| High-throughput | none | none |
| Computational (download data) | mRNA cleavage | 1 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
mRNA cleavage or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| mRNA cleavage 28 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| CFT1/YDR301W | IDA: Inferred from Direct Assay, TAS: Traceable Author Statement Assigned on 2002-04-10 |
manually curated | Gross S and Moore C (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5 |
SGD |
| CFT2/YLR115W | IDA: Inferred from Direct Assay, TAS: Traceable Author Statement Assigned on 2002-04-10 |
manually curated | Gross S and Moore C (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5 |
SGD |
| CLP1/YOR250C | IDA: Inferred from Direct Assay Assigned on 2002-04-09 |
manually curated | Gross S and Moore C (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5 |
SGD |
| DST1/YGL043W | IMP: Inferred from Mutant Phenotype Assigned on 2011-07-28 |
manually curated | Awrey DE, et al. (1998) Yeast transcript elongation factor (TFIIS), structure and function. II: RNA polymerase binding, transcript cleavage, and read-through. J Biol Chem 273(35):22595-605 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2011-07-28 |
manually curated | Weilbaecher RG, et al. (2003) Intrinsic transcript cleavage in yeast RNA polymerase II elongation complexes. J Biol Chem 278(26):24189-99 |
SGD | |
| FIP1/YJR093C | IDA: Inferred from Direct Assay Assigned on 2002-04-10 |
manually curated | Gross S and Moore C (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5 |
SGD |
| HRP1/YOL123W | IDA: Inferred from Direct Assay Assigned on 2002-04-09 |
manually curated | Gross S and Moore C (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5 |
SGD |
| MPE1/YKL059C | IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-12-02 |
manually curated | Vo LT, et al. (2001) Mpe1, a zinc knuckle protein, is an essential component of yeast cleavage and polyadenylation factor required for the cleavage and polyadenylation of mRNA. Mol Cell Biol 21(24):8346-56 |
SGD |
| NME1 | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| PCF11/YDR228C | IDA: Inferred from Direct Assay Assigned on 2002-04-09 |
manually curated | Gross S and Moore C (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5 |
SGD |
| PFS2/YNL317W | IDA: Inferred from Direct Assay Assigned on 2002-04-10 |
manually curated | Gross S and Moore C (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2002-04-10 |
manually curated | Ohnacker M, et al. (2000) The WD-repeat protein pfs2p bridges two essential factors within the yeast pre-mRNA 3'-end-processing complex. EMBO J 19(1):37-47 |
SGD | |
| POP1/YNL221C | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| POP3/YNL282W | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| POP4/YBR257W | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR002730, EBI:IPR016848 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| POP5/YAL033W | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| POP6/YGR030C | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| POP7/YBR167C | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| POP8/YBL018C | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| PTA1/YAL043C | IMP: Inferred from Mutant Phenotype Assigned on 2004-09-28 |
manually curated | Zhao J, et al. (1999) Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursor. Mol Cell Biol 19(11):7733-40 |
SGD |
| PTI1/YGR156W | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:PTA1, SGD:RNA14, SGD:PCF11 Assigned on 2003-01-06 |
manually curated | Skaar DA and Greenleaf AL (2002) The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Mol Cell 10(6):1429-39 |
SGD |
| RMP1/YLR145W | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| RNA14/YMR061W | IDA: Inferred from Direct Assay Assigned on 2002-04-09 |
manually curated | Gross S and Moore C (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5 |
SGD |
| RNA15/YGL044C | IDA: Inferred from Direct Assay Assigned on 2002-04-09 |
manually curated | Gross S and Moore C (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5 |
SGD |
| RNT1/YMR239C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2011-03-29 |
manually curated | Larose S, et al. (2007) RNase III-dependent regulation of yeast telomerase. J Biol Chem 282(7):4373-81 |
SGD |
| RPP1/YHR062C | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| SNM1/YDR478W | IPI: Inferred from Physical Interaction Assigned on 2007-03-08 |
manually curated | Gill T, et al. (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53 |
SGD |
| SSU72/YNL222W | IMP: Inferred from Mutant Phenotype Assigned on 2012-06-21 |
manually curated | He X, et al. (2003) Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1. Genes Dev 17(8):1030-42 |
SGD |
| YSH1/YLR277C | IMP: Inferred from Mutant Phenotype Assigned on 2009-04-16 |
manually curated | Garas M, et al. (2008) The role of the putative 3' end processing endonuclease Ysh1p in mRNA and snoRNA synthesis. RNA 14(12):2671-2684 |
SGD |
| YTH1/YPR107C | IDA: Inferred from Direct Assay, TAS: Traceable Author Statement Assigned on 2002-04-10 |
manually curated | Gross S and Moore C (2001) Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I. Proc Natl Acad Sci U S A 98(11):6080-5 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2002-04-10 |
manually curated | Barabino SM, et al. (2000) Distinct roles of two Yth1p domains in 3'-end cleavage and polyadenylation of yeast pre-mRNAs. EMBO J 19(14):3778-87 |
SGD | |
