Ontology: Biological Process (GO:0006348)

Definition: Repression of transcription of telomeric DNA by altering the structure of chromatin.

Synonyms: heterochromatic silencing at telomere; telomeric silencing; telomere chromatin silencing

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term chromatin silencing at telomere (52 genes) or to its variants containing one or more qualifiers (2 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	chromatin silencing at telomere	52
	NOT: chromatin silencing at telomere	2
High-throughput	none	none
Computational (download data)	chromatin silencing at telomere	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term chromatin silencing at telomere or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

NOT: chromatin silencing at telomere      2 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ISW2/YOR304W	IMP: Inferred from Mutant Phenotype Assigned on 2007-08-17	manually curated	Mueller JE, et al.  (2007) Isw2 regulates gene silencing at the ribosomal DNA locus in Saccharomyces cerevisiae. Biochem Biophys Res Commun 361(4):1017-21	SGD
SCS22/YBL091C-A	IDA: Inferred from Direct Assay, IGI: Inferred from Genetic Interaction with SGD:SCS2, IMP: Inferred from Mutant Phenotype Assigned on 2003-11-04	manually curated	Craven RJ and Petes TD  (2001) The Saccharomyces cerevisiae suppressor of choline sensitivity (SCS2) gene is a multicopy Suppressor of mec1 telomeric silencing defects. Genetics 158(1):145-54	SGD

chromatin silencing at telomere      52 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ADA2/YDR448W	IMP: Inferred from Mutant Phenotype Assigned on 2009-11-13	manually curated	Jacobson S and Pillus L  (2009) The SAGA subunit Ada2 functions in transcriptional silencing. Mol Cell Biol 29(22):6033-45	SGD
ASF1/YJL115W	IGI: Inferred from Genetic Interaction with SGD:RLF2 Assigned on 2006-09-15	manually curated	Mousson F, et al.  (2005) Structural basis for the interaction of Asf1 with histone H3 and its functional implications. Proc Natl Acad Sci U S A 102(17):5975-80	SGD
BRE1/YDL074C	IMP: Inferred from Mutant Phenotype Assigned on 2009-11-11	manually curated	Wood A, et al.  (2003) Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell 11(1):267-74	SGD
BRE2/YLR015W	IMP: Inferred from Mutant Phenotype Assigned on 2002-02-12	manually curated	Miller T, et al.  (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2005-05-25	manually curated	Krogan NJ, et al.  (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5	SGD
DLS1/YJL065C	IMP: Inferred from Mutant Phenotype Assigned on 2004-02-10	manually curated	Iida T and Araki H  (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27	SGD
DOT1/YDR440W	IMP: Inferred from Mutant Phenotype Assigned on 2002-09-18	manually curated	San-Segundo PA and Roeder GS  (2000) Role for the silencing protein Dot1 in meiotic checkpoint control. Mol Biol Cell 11(10):3601-15	SGD
DOT6/YER088C	IGI: Inferred from Genetic Interaction Assigned on 2002-08-08	manually curated	Singer MS, et al.  (1998) Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics 150(2):613-32	SGD
ESC1/YMR219W	IMP: Inferred from Mutant Phenotype Assigned on 2003-01-13	manually curated	Andrulis ED, et al.  (2002) Esc1, a nuclear periphery protein required for Sir4-based plasmid anchoring and partitioning. Mol Cell Biol 22(23):8292-301	SGD
FUN30/YAL019W	IMP: Inferred from Mutant Phenotype Assigned on 2009-12-15	manually curated	Neves-Costa A, et al.  (2009) The SNF2-family member Fun30 promotes gene silencing in heterochromatic loci. PLoS One 4(12):e8111	SGD
GTR1/YML121W	IMP: Inferred from Mutant Phenotype Assigned on 2008-04-16	manually curated	Sekiguchi T, et al.  (2008) Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae. Biochem Biophys Res Commun 368(3):748-54	SGD
HAT1/YPL001W	IGI: Inferred from Genetic Interaction with SGD:HHT1, SGD:HHT2 Assigned on 2007-02-16	manually curated	Kelly TJ, et al.  (2000) Type B histone acetyltransferase Hat1p participates in telomeric silencing. Mol Cell Biol 20(19):7051-8	SGD
	IGI: Inferred from Genetic Interaction with SGD:HHT1, SGD:HHT2 Assigned on 2007-02-16	manually curated	Ai X and Parthun MR  (2004) The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly. Mol Cell 14(2):195-205	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR017380, EBI:IPR013523 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HAT2/YEL056W	IGI: Inferred from Genetic Interaction with SGD:HHT1, SGD:HHT2 Assigned on 2007-02-16	manually curated	Kelly TJ, et al.  (2000) Type B histone acetyltransferase Hat1p participates in telomeric silencing. Mol Cell Biol 20(19):7051-8	SGD
HIF1/YLL022C	IGI: Inferred from Genetic Interaction with SGD:HHT1, SGD:HHT2 Assigned on 2007-02-16	manually curated	Poveda A, et al.  (2004) Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus. J Biol Chem 279(16):16033-43	SGD
	IGI: Inferred from Genetic Interaction with SGD:HHT1, SGD:HHT2 Assigned on 2007-02-16	manually curated	Ai X and Parthun MR  (2004) The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly. Mol Cell 14(2):195-205	SGD
HST3/YOR025W	IGI: Inferred from Genetic Interaction Assigned on 2002-10-01	manually curated	Brachmann CB, et al.  (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9(23):2888-902	SGD
HST4/YDR191W	IGI: Inferred from Genetic Interaction Assigned on 2002-10-01	manually curated	Brachmann CB, et al.  (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9(23):2888-902	SGD
IES3/YLR052W	IMP: Inferred from Mutant Phenotype Assigned on 2007-06-27	manually curated	Yu EY, et al.  (2007) Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex. Mol Cell Biol 27(16):5639-49	SGD
IFH1/YLR223C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Singer MS, et al.  (1998) Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics 150(2):613-32	SGD
INO80/YGL150C	IMP: Inferred from Mutant Phenotype Assigned on 2008-04-16	manually curated	Sekiguchi T, et al.  (2008) Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae. Biochem Biophys Res Commun 368(3):748-54	SGD
ISW2/YOR304W	IMP: Inferred from Mutant Phenotype Assigned on 2004-02-10	manually curated	Iida T and Araki H  (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27	SGD
ITC1/YGL133W	IMP: Inferred from Mutant Phenotype Assigned on 2004-02-10	manually curated	Iida T and Araki H  (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27	SGD
MCM10/YIL150C	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:SIR2, SGD:SIR3 Assigned on 2005-09-26	manually curated	Liachko I and Tye BK  (2005) Mcm10 is required for the maintenance of transcriptional silencing in Saccharomyces cerevisiae. Genetics 171(2):503-15	SGD
MCM3/YEL032W	IMP: Inferred from Mutant Phenotype Assigned on 2009-01-09	manually curated	Liachko I and Tye BK  (2009) Mcm10 mediates the interaction between DNA replication and silencing machineries. Genetics 181(2):379-91	SGD
MCM5/YLR274W	IMP: Inferred from Mutant Phenotype Assigned on 2007-08-16	manually curated	Rehman MA, et al.  (2006) Differential requirement of DNA replication factors for subtelomeric ARS consensus sequence protosilencers in Saccharomyces cerevisiae. Genetics 174(4):1801-10	SGD
MCM7/YBR202W	IMP: Inferred from Mutant Phenotype Assigned on 2009-01-09	manually curated	Liachko I and Tye BK  (2009) Mcm10 mediates the interaction between DNA replication and silencing machineries. Genetics 181(2):379-91	SGD
MEC3/YLR288C	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-21	manually curated	Corda Y, et al.  (1999) Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions. Nat Genet 21(2):204-8	SGD
MPS3/YJL019W	IMP: Inferred from Mutant Phenotype Assigned on 2012-12-11	manually curated	Ghosh S, et al.  (2012) Acetylation of the SUN protein Mps3 by Eco1 regulates its function in nuclear organization. Mol Biol Cell 23(13):2546-59	SGD
MRC1/YCL061C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2001-08-14	manually curated	Hu F, et al.  (2001) Asf1 links Rad53 to control of chromatin assembly. Genes Dev 15(9):1061-6	SGD
NPT1/YOR209C	IMP: Inferred from Mutant Phenotype Assigned on 2002-07-08	manually curated	Sandmeier JJ, et al.  (2002) Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway. Genetics 160(3):877-89	SGD
ORC2/YBR060C	IMP: Inferred from Mutant Phenotype Assigned on 2007-08-16	manually curated	Rehman MA, et al.  (2006) Differential requirement of DNA replication factors for subtelomeric ARS consensus sequence protosilencers in Saccharomyces cerevisiae. Genetics 174(4):1801-10	SGD
PNC1/YGL037C	IMP: Inferred from Mutant Phenotype Assigned on 2002-07-08	manually curated	Sandmeier JJ, et al.  (2002) Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway. Genetics 160(3):877-89	SGD

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