Ontology: Biological Process (GO:0006283)

Definition: The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.

Synonyms: TCR; TC-NER; transcription-coupled NER; transcription-coupled repair

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term transcription-coupled nucleotide-excision repair (9 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	transcription-coupled nucleotide-excision repair	9
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term transcription-coupled nucleotide-excision repair or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

transcription-coupled nucleotide-excision repair      9 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DEF1/YKL054C	IGI: Inferred from Genetic Interaction with SGD:HPR1, SGD:RAD7 Assigned on 2007-07-06	manually curated	Gaillard H, et al.  (2007) A new connection of mRNP biogenesis and export with transcription-coupled repair. Nucleic Acids Res 35(12):3893-906	SGD
HPR1/YDR138W	IMP: Inferred from Mutant Phenotype Assigned on 2007-07-06	manually curated	Gaillard H, et al.  (2007) A new connection of mRNP biogenesis and export with transcription-coupled repair. Nucleic Acids Res 35(12):3893-906	SGD
RAD26/YJR035W	IGI: Inferred from Genetic Interaction with SGD:RPB9, SGD:RAD26 Assigned on 2007-03-16	manually curated	Li S, et al.  (2006) Modulation of Rad26- and Rpb9-mediated DNA repair by different promoter elements. J Biol Chem 281(48):36643-51	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-16	manually curated	van Gool AJ, et al.  (1994) RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6. EMBO J 13(22):5361-9	SGD
RPB9/YGL070C	IGI: Inferred from Genetic Interaction with SGD:RAD16, SGD:RAD26 Assigned on 2007-03-16	manually curated	Li S, et al.  (2006) Evidence that the transcription elongation function of Rpb9 is involved in transcription-coupled DNA repair in Saccharomyces cerevisiae. Mol Cell Biol 26(24):9430-41	SGD
SAC3/YDR159W	IMP: Inferred from Mutant Phenotype Assigned on 2007-07-06	manually curated	Gaillard H, et al.  (2007) A new connection of mRNP biogenesis and export with transcription-coupled repair. Nucleic Acids Res 35(12):3893-906	SGD
SUB2/YDL084W	IMP: Inferred from Mutant Phenotype Assigned on 2007-07-06	manually curated	Gaillard H, et al.  (2007) A new connection of mRNP biogenesis and export with transcription-coupled repair. Nucleic Acids Res 35(12):3893-906	SGD
THO2/YNL139C	IMP: Inferred from Mutant Phenotype Assigned on 2007-07-06	manually curated	Gaillard H, et al.  (2007) A new connection of mRNP biogenesis and export with transcription-coupled repair. Nucleic Acids Res 35(12):3893-906	SGD
THP1/YOL072W	IMP: Inferred from Mutant Phenotype Assigned on 2007-07-06	manually curated	Gaillard H, et al.  (2007) A new connection of mRNP biogenesis and export with transcription-coupled repair. Nucleic Acids Res 35(12):3893-906	SGD
YRA1/YDR381W	IMP: Inferred from Mutant Phenotype Assigned on 2007-07-06	manually curated	Gaillard H, et al.  (2007) A new connection of mRNP biogenesis and export with transcription-coupled repair. Nucleic Acids Res 35(12):3893-906	SGD

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