GO term: DNA repair 
Ontology: Biological Process (GO:0006281)
Definition: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
View Ontology:
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(text)
Definition: The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
DNA repair (188 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | DNA repair | 64 |
| High-throughput (download data) | DNA repair | 2 |
| Computational (download data) | DNA repair | 166 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
DNA repair or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| DNA repair 188 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| SIR2/YDL042C | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| SIT4/YDL047W | IMP: Inferred from Mutant Phenotype Assigned on 2005-03-09 |
manually curated | Douville J, et al. (2004) The yeast phosphotyrosyl phosphatase activator protein, yPtpa1/Rrd1, interacts with Sit4 phosphatase to mediate resistance to 4-nitroquinoline-1-oxide and UVA. Curr Genet 46(2):72-81 |
SGD |
| SLX1/YBR228W | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| SLX4/YLR135W | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| SLX5/YDL013W | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| SLX8/YER116C | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| SMC1/YFL008W | IEA: Inferred from Electronic Annotation with EBI:IPR024704 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| SMC2/YFR031C | IEA: Inferred from Electronic Annotation with EBI:IPR024704 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| SMC4/YLR086W | IEA: Inferred from Electronic Annotation with EBI:IPR024704 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| SMC5/YOL034W | IDA: Inferred from Direct Assay Assigned on 2002-06-22 |
manually curated | Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2006-03-09 |
manually curated | Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR027131 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SMC6/YLR383W | IDA: Inferred from Direct Assay Assigned on 2002-06-22 |
manually curated | Fujioka Y, et al. (2002) Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. J Biol Chem 277(24):21585-91 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2006-03-09 |
manually curated | Zhao X and Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR027132 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SOH1/YGL127C | IPI: Inferred from Physical Interaction Assigned on 2002-10-09 |
manually curated | Fan HY, et al. (1996) Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae. Genetics 142(3):749-59 |
SGD |
| SPT10/YJL127C | IMP: Inferred from Mutant Phenotype Assigned on 2006-11-08 |
manually curated | Tounekti K, et al. (2006) Deletion of the chromatin remodeling gene SPT10 sensitizes yeast cells to a subclass of DNA-damaging agents. Environ Mol Mutagen 47(9):707-17 |
SGD |
| SPT16/YGL207W | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| SRS2/YJL092W | IGI: Inferred from Genetic Interaction Assigned on 2001-01-18 |
manually curated | Milne GT, et al. (1995) Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51. Genetics 139(3):1189-99 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SSL1/YLR005W | IEA: Inferred from Electronic Annotation with EBI:IPR004595 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| SSL2/YIL143C | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| SWC4/YGR002C | IDA: Inferred from Direct Assay Assigned on 2007-01-03 |
manually curated | Utley RT, et al. (2005) Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4. Mol Cell Biol 25(18):8179-90 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR027109 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| TDP1/YBR223C | IMP: Inferred from Mutant Phenotype Assigned on 2002-10-09 |
manually curated | Pouliot JJ, et al. (1999) Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes. Science 286(5439):552-5 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2009-01-21 |
manually curated | Liu C, et al. (2004) The role of TDP1 from budding yeast in the repair of DNA damage. DNA Repair (Amst) 3(6):593-601 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR010347 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| TEL1/YBL088C | IEA: Inferred from Electronic Annotation with EBI:IPR015519 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| TFB1/YDR311W | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| TFB2/YPL122C | IEA: Inferred from Electronic Annotation with EBI:KW-0228, EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| TFB4/YPR056W | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| TFB5/YDR079C-A | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| TOF1/YNL273W | IGI: Inferred from Genetic Interaction with SGD:RAD9, IMP: Inferred from Mutant Phenotype Assigned on 2009-07-13 |
manually curated | Redon C, et al. (2006) Genetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damage. Genetics 172(1):67-76 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| TPP1/YMR156C | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| TRA1/YHR099W | IDA: Inferred from Direct Assay Assigned on 2007-01-03 |
manually curated | Utley RT, et al. (2005) Regulation of NuA4 histone acetyltransferase activity in transcription and DNA repair by phosphorylation of histone H4. Mol Cell Biol 25(18):8179-90 |
SGD |
| TRM2/YKR056W | IGI: Inferred from Genetic Interaction with SGD:RAD52, SGD:EXO1, SGD:YKU80, IMP: Inferred from Mutant Phenotype Assigned on 2007-01-17 |
manually curated | Choudhury SA, et al. (2007) Functional and genetic analysis of the Saccharomyces cerevisiae RNC1/TRM2: evidences for its involvement in DNA double-strand break repair. Mol Cell Biochem 300(1-2):215-26 |
SGD |
| UBI4/YLL039C | IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| UNG1/YML021C | IMP: Inferred from Mutant Phenotype Assigned on 2002-10-23 |
manually curated | Impellizzeri KJ, et al. (1991) The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair. J Bacteriol 173(21):6807-10 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR002043, EBI:IPR018085 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0234 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
