Ontology: Biological Process (GO:0006276)

Definition: The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division.

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This table lists the methods used to annotate genes either directly to the term plasmid maintenance (6 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	plasmid maintenance	6
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term plasmid maintenance or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

plasmid maintenance      6 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DML1/YMR211W	IMP: Inferred from Mutant Phenotype Assigned on 2003-04-29	manually curated	Gurvitz A, et al.  (2002) Preliminary characterisation of DML1, an essential Saccharomyces cerevisiae gene related to misato of Drosophila melanogaster. FEMS Yeast Res 2(2):123-35	SGD
PAH1/YMR165C	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-01	manually curated	Irie K, et al.  (1993) A gene, SMP2, involved in plasmid maintenance and respiration in Saccharomyces cerevisiae encodes a highly charged protein. Mol Gen Genet 236(2-3):283-8	SGD
RAF1/R0030W	IMP: Inferred from Mutant Phenotype Assigned on 2006-08-17	manually curated	Murray JA, et al.  (1987) Antagonistic controls regulate copy number of the yeast 2 mu plasmid. EMBO J 6(13):4205-12	SGD
RSC2/YLR357W	IMP: Inferred from Mutant Phenotype Assigned on 2004-03-26	manually curated	Wong MC, et al.  (2002) RSC2, encoding a component of the RSC nucleosome remodeling complex, is essential for 2 microm plasmid maintenance in Saccharomyces cerevisiae. Mol Cell Biol 22(12):4218-29	UniProtKB
SMP3/YOR149C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Irie K, et al.  (1991) Mutations in a Saccharomyces cerevisiae host showing increased holding stability of the heterologous plasmid pSR1. Mol Gen Genet 225(2):257-65	SGD
ULP2/YIL031W	IMP: Inferred from Mutant Phenotype Assigned on 2002-04-03	manually curated	Li SJ and Hochstrasser M  (2000) The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol Cell Biol 20(7):2367-77	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2002-04-03	manually curated	Strunnikov AV, et al.  (2001) Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation. Genetics 158(1):95-107	SGD

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