Ontology: Biological Process (GO:0006270)

Definition: The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

Synonyms: DNA re-replication initiation; DNA endoreduplication initiation; DNA-dependent DNA replication initiation

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term DNA replication initiation (33 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	DNA replication initiation	32
High-throughput	none	none
Computational (download data)	DNA replication initiation	8

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term DNA replication initiation or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

DNA replication initiation      33 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
RAD53/YPL153C	IMP: Inferred from Mutant Phenotype Assigned on 2006-08-16	manually curated	Dohrmann PR and Sclafani RA  (2006) Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae. Genetics 174(1):87-99	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR016256 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SLD2/YKL108W	IGI: Inferred from Genetic Interaction with SGD:CDC45, SGD:DPB11 Assigned on 2011-07-19	manually curated	Tanaka S, et al.  (2007) CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Nature 445(7125):328-32	SGD
	IGI: Inferred from Genetic Interaction with SGD:SLD3, SGD:DPB11 Assigned on 2011-07-19	manually curated	Zegerman P and Diffley JF  (2007) Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 445(7125):281-5	SGD
SLD3/YGL113W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-04-12	manually curated	Kamimura Y, et al.  (2001) Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae. EMBO J 20(8):2097-107	SGD

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