GO term: DNA replication initiation 
Ontology: Biological Process (GO:0006270)
Definition: The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
Synonyms: DNA re-replication initiation; DNA endoreduplication initiation; DNA-dependent DNA replication initiation
View Ontology:
(graph) | 
(text)
Definition: The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
Synonyms: DNA re-replication initiation; DNA endoreduplication initiation; DNA-dependent DNA replication initiation
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
DNA replication initiation (33 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | DNA replication initiation | 32 |
| High-throughput | none | none |
| Computational (download data) | DNA replication initiation | 8 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
DNA replication initiation or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| DNA replication initiation 33 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ADK1/YDR226W | IMP: Inferred from Mutant Phenotype Assigned on 2011-03-15 |
manually curated | Ma L, et al. (2010) Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle 9(21):4399-410 |
SGD |
| BMH2/YDR099W | IGI: Inferred from Genetic Interaction with SGD:BMH1 Assigned on 2009-11-30 |
manually curated | Yahyaoui W and Zannis-Hadjopoulos M (2009) 14-3-3 proteins function in the initiation and elongation steps of DNA replication in Saccharomyces cerevisiae. J Cell Sci 122(Pt 24):4419-26 |
SGD |
| CDC45/YLR103C | IGI: Inferred from Genetic Interaction with SGD:MCM7, IMP: Inferred from Mutant Phenotype Assigned on 2007-08-02 |
manually curated | Hennessy KM, et al. (1991) A group of interacting yeast DNA replication genes. Genes Dev 5(6):958-69 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR003874 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| CDC7/YDL017W | IMP: Inferred from Mutant Phenotype Assigned on 2006-12-11 |
manually curated | Donaldson AD, et al. (1998) Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev 12(4):491-501 |
SGD |
| CHL1/YPL008W | IMP: Inferred from Mutant Phenotype Assigned on 2011-03-15 |
manually curated | Ma L, et al. (2010) Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle 9(21):4399-410 |
SGD |
| CLF1/YLR117C | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:ORC2 Assigned on 2008-02-01 |
manually curated | Zhu W, et al. (2002) Evidence that the pre-mRNA splicing factor Clf1p plays a role in DNA replication in Saccharomyces cerevisiae. Genetics 160(4):1319-33 |
SGD |
| CTF18/YMR078C | IMP: Inferred from Mutant Phenotype Assigned on 2011-03-15 |
manually curated | Ma L, et al. (2010) Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle 9(21):4399-410 |
SGD |
| CTF3/YLR381W | IMP: Inferred from Mutant Phenotype Assigned on 2011-03-15 |
manually curated | Ma L, et al. (2010) Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle 9(21):4399-410 |
SGD |
| CTF4/YPR135W | IMP: Inferred from Mutant Phenotype Assigned on 2011-03-15 |
manually curated | Ma L, et al. (2010) Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle 9(21):4399-410 |
SGD |
| DBF4/YDR052C | IPI: Inferred from Physical Interaction with SGD:CDC7 Assigned on 2006-12-18 |
manually curated | Jackson AL, et al. (1993) Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol Cell Biol 13(5):2899-908 |
SGD |
| DPB11/YJL090C | TAS: Traceable Author Statement Assigned on 2003-05-08 |
manually curated | Takayama Y, et al. (2003) GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev 17(9):1153-65 |
SGD |
| MCM1/YMR043W | IMP: Inferred from Mutant Phenotype Assigned on 2010-04-21 |
manually curated | Chang VK, et al. (2003) Mcm1 binds replication origins. J Biol Chem 278(8):6093-100 |
SGD |
| MCM10/YIL150C | IGI: Inferred from Genetic Interaction with SGD:MCM7, IMP: Inferred from Mutant Phenotype Assigned on 2007-08-13 |
manually curated | Homesley L, et al. (2000) Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev 14(8):913-26 |
SGD |
| IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-01-18 |
manually curated | Merchant AM, et al. (1997) A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae. Mol Cell Biol 17(6):3261-71 |
SGD | |
| MCM2/YBL023C | IEA: Inferred from Electronic Annotation with EBI:IPR008045 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| MCM3/YEL032W | IMP: Inferred from Mutant Phenotype Assigned on 2007-08-14 |
manually curated | Lei M, et al. (2002) Two mcm3 mutations affect different steps in the initiation of DNA replication. J Biol Chem 277(34):30824-31 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR008046 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| MCM4/YPR019W | IGI: Inferred from Genetic Interaction with SGD:MCM5 Assigned on 2007-08-02 |
manually curated | Hennessy KM, et al. (1991) A group of interacting yeast DNA replication genes. Genes Dev 5(6):958-69 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR008047 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| MCM5/YLR274W | IMP: Inferred from Mutant Phenotype Assigned on 2007-08-01 |
manually curated | Hennessy KM, et al. (1990) Subcellular localization of yeast CDC46 varies with the cell cycle. Genes Dev 4(12B):2252-63 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR008048 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| MCM6/YGL201C | IPI: Inferred from Physical Interaction Assigned on 2002-12-02 |
manually curated | Aparicio OM, et al. (1997) Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 91(1):59-69 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR008049 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| MCM7/YBR202W | IGI: Inferred from Genetic Interaction with SGD:MCM10, IMP: Inferred from Mutant Phenotype Assigned on 2007-08-13 |
manually curated | Homesley L, et al. (2000) Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev 14(8):913-26 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:CDC45, IMP: Inferred from Mutant Phenotype Assigned on 2007-08-02 |
manually curated | Hennessy KM, et al. (1991) A group of interacting yeast DNA replication genes. Genes Dev 5(6):958-69 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR008050 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| NOC3/YLR002C | IDA: Inferred from Direct Assay Assigned on 2002-08-20 |
manually curated | Zhang Y, et al. (2002) Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell 109(7):849-60 |
SGD |
| ORC1/YML065W | IMP: Inferred from Mutant Phenotype Assigned on 2007-09-28 |
manually curated | Gibson DG, et al. (2006) Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae. Genes Cells 11(6):557-73 |
SGD |
| ORC2/YBR060C | IGI: Inferred from Genetic Interaction with SGD:MCM4, IMP: Inferred from Mutant Phenotype Assigned on 2007-08-02 |
manually curated | Loo S, et al. (1995) The origin recognition complex in silencing, cell cycle progression, and DNA replication. Mol Biol Cell 6(6):741-56 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2007-09-28 |
manually curated | Gibson DG, et al. (2006) Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae. Genes Cells 11(6):557-73 |
SGD | |
| ORC3/YLL004W | IMP: Inferred from Mutant Phenotype Assigned on 2007-09-28 |
manually curated | Gibson DG, et al. (2006) Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae. Genes Cells 11(6):557-73 |
SGD |
| ORC4/YPR162C | IMP: Inferred from Mutant Phenotype Assigned on 2007-09-28 |
manually curated | Gibson DG, et al. (2006) Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae. Genes Cells 11(6):557-73 |
SGD |
| ORC5/YNL261W | IGI: Inferred from Genetic Interaction with SGD:MCM4, IMP: Inferred from Mutant Phenotype Assigned on 2007-08-02 |
manually curated | Loo S, et al. (1995) The origin recognition complex in silencing, cell cycle progression, and DNA replication. Mol Biol Cell 6(6):741-56 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2007-09-28 |
manually curated | Gibson DG, et al. (2006) Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae. Genes Cells 11(6):557-73 |
SGD | |
| ORC6/YHR118C | IMP: Inferred from Mutant Phenotype Assigned on 2010-05-14 |
manually curated | Semple JW, et al. (2006) An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes. EMBO J 25(21):5150-8 |
SGD |
| POL1/YNL102W | IC: Inferred By Curator from alpha DNA polymerase:primase complex Assigned on 2006-09-13 |
manually curated | Plevani P, et al. (1985) Polypeptide structure of DNA primase from a yeast DNA polymerase-primase complex. J Biol Chem 260(11):7102-7 |
SGD |
| POL12/YBL035C | IMP: Inferred from Mutant Phenotype Assigned on 2006-09-14 |
manually curated | Foiani M, et al. (1994) The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication. Mol Cell Biol 14(2):923-33 |
SGD |
| PRI1/YIR008C | IC: Inferred By Curator from alpha DNA polymerase:primase complex Assigned on 2006-09-13 |
manually curated | Plevani P, et al. (1985) Polypeptide structure of DNA primase from a yeast DNA polymerase-primase complex. J Biol Chem 260(11):7102-7 |
SGD |
| PRI2/YKL045W | IC: Inferred By Curator from alpha DNA polymerase:primase complex Assigned on 2006-09-13 |
manually curated | Plevani P, et al. (1985) Polypeptide structure of DNA primase from a yeast DNA polymerase-primase complex. J Biol Chem 260(11):7102-7 |
SGD |
