Ontology: Biological Process (GO:0006260)

Definition: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term DNA replication (75 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	DNA replication	15
	NOT: DNA replication	1
High-throughput	none	none
Computational (download data)	DNA replication	69

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term DNA replication or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

DNA replication      75 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
RFC5/YBR087W	IEA: Inferred from Electronic Annotation with EBI:IPR008921 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
RIM1/YCR028C-A	IEA: Inferred from Electronic Annotation with EBI:IPR011344 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
RNR1/YER070W	IEA: Inferred from Electronic Annotation with EBI:IPR000788, EBI:IPR008926, EBI:IPR013509 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00326 Last Updated 2013-03-02	computational	UniProt-GOA  (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
RNR2/YJL026W	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00326 Last Updated 2013-03-02	computational	UniProt-GOA  (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
RNR3/YIL066C	IEA: Inferred from Electronic Annotation with EBI:IPR000788, EBI:IPR008926, EBI:IPR013509 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00326 Last Updated 2013-03-02	computational	UniProt-GOA  (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
RNR4/YGR180C	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00326 Last Updated 2013-03-02	computational	UniProt-GOA  (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
RRM3/YHR031C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-12-05	manually curated	Ivessa AS, et al.  (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100(4):479-89	SGD
SGS1/YMR190C	IEA: Inferred from Electronic Annotation with EBI:IPR018982 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SLD2/YKL108W	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
SLD3/YGL113W	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
SLD5/YDR489W	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
SLD7/YOR060C	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
SLX4/YLR135W	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-08	manually curated	Kaliraman V and Brill SJ  (2002) Role of SGS1 and SLX4 in maintaining rDNA structure in Saccharomyces cerevisiae. Curr Genet 41(6):389-400	SGD
SPT16/YGL207W	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
TOF1/YNL273W	IMP: Inferred from Mutant Phenotype Assigned on 2009-07-10	manually curated	Tourriere H, et al.  (2005) Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53. Mol Cell 19(5):699-706	SGD

NOT: DNA replication      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
POL5/YEL055C	IMP: Inferred from Mutant Phenotype Assigned on 2006-10-13	manually curated	Shimizu K, et al.  (2002) The fifth essential DNA polymerase phi in Saccharomyces cerevisiae is localized to the nucleolus and plays an important role in synthesis of rRNA. Proc Natl Acad Sci U S A 99(14):9133-8	SGD

SGD Home About Blog Site Map Help Terms of Use
© Stanford University, Stanford, CA 94305.