GO term: pentose-phosphate shunt 
Ontology: Biological Process (GO:0006098)
Definition: The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses.
Synonyms: hexose monophosphate pathway; pentose phosphate pathway; pentose phosphate shunt; pentose-phosphate pathway
Definition: The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses.
Synonyms: hexose monophosphate pathway; pentose phosphate pathway; pentose phosphate shunt; pentose-phosphate pathway
This table lists the methods used to annotate genes either directly to the term
pentose-phosphate shunt (14 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | pentose-phosphate shunt | 6 |
| High-throughput | none | none |
| Computational (download data) | pentose-phosphate shunt | 9 |
Links to Additional Annotations:
Annotation details for genes that have been directly annotated to the term
pentose-phosphate shunt or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| pentose-phosphate shunt 14 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| GND1/YHR183W | IEA: Inferred from Electronic Annotation with EBI:IPR006113, EBI:IPR006114, EBI:IPR006115, EBI:IPR006183, EBI:IPR006184 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:KW-0570 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| GND2/YGR256W | IEA: Inferred from Electronic Annotation with EBI:IPR006113, EBI:IPR006114, EBI:IPR006115, EBI:IPR006183, EBI:IPR006184 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:KW-0570 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| NQM1/YGR043C | IEA: Inferred from Electronic Annotation with EBI:IPR004730 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:KW-0570 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| PGI1/YBR196C | IMP: Inferred from Mutant Phenotype Assigned on 2005-07-28 |
manually curated | Boles E, et al. (1993) The role of the NAD-dependent glutamate dehydrogenase in restoring growth on glucose of a Saccharomyces cerevisiae phosphoglucose isomerase mutant. Eur J Biochem 217(1):469-77 |
SGD |
| RKI1/YOR095C | IGI: Inferred from Genetic Interaction Assigned on 2002-06-07 |
manually curated | Miosga T and Zimmermann FK (1996) Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway. Curr Genet 30(5):404-9 |
SGD |
| RPE1/YJL121C | IMP: Inferred from Mutant Phenotype Assigned on 2002-06-07 |
manually curated | Miosga T and Zimmermann FK (1996) Cloning and characterization of the first two genes of the non-oxidative part of the Saccharomyces cerevisiae pentose-phosphate pathway. Curr Genet 30(5):404-9 |
SGD |
| SOL1/YNR034W | IEA: Inferred from Electronic Annotation with EBI:IPR005900 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB |
| SOL2/YCR073W-A | IEA: Inferred from Electronic Annotation with EBI:IPR005900 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB |
| SOL3/YHR163W | IEA: Inferred from Electronic Annotation with EBI:IPR005900 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB |
| SOL4/YGR248W | IEA: Inferred from Electronic Annotation with EBI:IPR005900 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB |
| TAL1/YLR354C | TAS: Traceable Author Statement Assigned on 2002-09-30 |
manually curated | Walfridsson M, et al. (1995) Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase. Appl Environ Microbiol 61(12):4184-90 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2002-09-30 |
manually curated | Schaaff-Gerstenschlager I and Zimmermann FK (1993) Pentose-phosphate pathway in Saccharomyces cerevisiae: analysis of deletion mutants for transketolase, transaldolase, and glucose 6-phosphate dehydrogenase. Curr Genet 24(5):373-6 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR004730 Last Updated 2009-11-20 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0570 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| TKL1/YPR074C | TAS: Traceable Author Statement Assigned on 2002-09-30 |
manually curated | Walfridsson M, et al. (1995) Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase. Appl Environ Microbiol 61(12):4184-90 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2002-09-30 |
manually curated | Schaaff-Gerstenschlager I and Zimmermann FK (1993) Pentose-phosphate pathway in Saccharomyces cerevisiae: analysis of deletion mutants for transketolase, transaldolase, and glucose 6-phosphate dehydrogenase. Curr Genet 24(5):373-6 |
SGD | |
| TKL2/YBR117C | IGI: Inferred from Genetic Interaction Assigned on 2002-09-30 |
manually curated | Schaaff-Gerstenschlager I, et al. (1993) TKL2, a second transketolase gene of Saccharomyces cerevisiae. Cloning, sequence and deletion analysis of the gene. Eur J Biochem 217(1):487-92 |
SGD |
| TPI1/YDR050C | IEA: Inferred from Electronic Annotation with EBI:KW-0570 Last Updated 2009-11-20 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
This diagram shows the local area of the Gene Ontology and the numbers of yeast genes annotated to each term in the diagram. Within the diagram, click on the blue arrow to navigate up the tree and click on a GO term name to go to its GO term page.
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