Ontology: Cellular Component (GO:0005946)

Definition: A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present.

Synonyms: trehalose-6-phosphate synthase complex; trehalose-6-phosphate synthase/phosphatase; UDP-glucose-glucosephosphate glucosyltransferase complex

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) (4 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)	4
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)      4 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
TPS1/YBR126C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-04-23	manually curated	Bell W, et al.  (1998) Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex. J Biol Chem 273(50):33311-9	SGD
	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Bell W, et al.  (1992) Characterization of the 56-kDa subunit of yeast trehalose-6-phosphate synthase and cloning of its gene reveal its identity with the product of CIF1, a regulator of carbon catabolite inactivation. Eur J Biochem 209(3):951-9	SGD
TPS2/YDR074W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-04-23	manually curated	Bell W, et al.  (1998) Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex. J Biol Chem 273(50):33311-9	SGD
TPS3/YMR261C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-04-23	manually curated	Bell W, et al.  (1998) Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex. J Biol Chem 273(50):33311-9	SGD
TSL1/YML100W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2002-04-23	manually curated	Bell W, et al.  (1998) Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex. J Biol Chem 273(50):33311-9	SGD

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