GO term: plasma membrane 
Ontology: Cellular Component (GO:0005886)
Definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Synonyms: bacterial inner membrane; cell membrane; cytoplasmic membrane; inner endospore membrane; juxtamembrane; plasmalemma; plasma membrane lipid bilayer
View Ontology:
(graph) | 
(text)
Definition: The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Synonyms: bacterial inner membrane; cell membrane; cytoplasmic membrane; inner endospore membrane; juxtamembrane; plasmalemma; plasma membrane lipid bilayer
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
plasma membrane (429 genes)
or to its variants containing one or more
qualifiers (6 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | colocalizes_with: plasma membrane | 1 |
| NOT: plasma membrane | 3 | |
| plasma membrane | 261 | |
| High-throughput (download data) | plasma membrane | 107 |
| Computational (download data) | NOT: plasma membrane | 2 |
| plasma membrane | 226 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
plasma membrane or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| NOT: plasma membrane 5 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| CDC25/YLR310C | IDA: Inferred from Direct Assay Assigned on 2009-04-01 |
manually curated | Tisi R, et al. (2008) The budding yeast RasGEF Cdc25 reveals an unexpected nuclear localization. Biochim Biophys Acta 1783(12):2363-74 |
SGD |
| IST2/YBR086C | IDA: Inferred from Direct Assay Assigned on 2013-02-01 |
manually curated | Manford AG, et al. (2012) ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology. Dev Cell 23(6):1129-40 |
SGD |
| MDL1/YLR188W | IRD: Inferred from Rapid Divergence with PANTHER:PTHR24221_AN459 Assigned on 2010-07-28 |
computational | Gaudet P, et al. (2011) Annotation inferences using phylogenetic trees. |
RefGenome |
| MDL2/YPL270W | IRD: Inferred from Rapid Divergence with PANTHER:PTHR24221_AN459 Assigned on 2010-07-28 |
computational | Gaudet P, et al. (2011) Annotation inferences using phylogenetic trees. |
RefGenome |
| TCB3/YML072C | IDA: Inferred from Direct Assay Assigned on 2013-02-01 |
manually curated | Manford AG, et al. (2012) ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology. Dev Cell 23(6):1129-40 |
SGD |
| colocalizes_with: plasma membrane 1 gene directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| SLI1/YGR212W | IDA: Inferred from Direct Assay Assigned on 2005-05-05 |
manually curated | Momoi M, et al. (2004) SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast. Biochem J 381(Pt 1):321-8 |
SGD |
| plasma membrane 429 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ADE17/YMR120C | IDA: Inferred from Direct Assay Assigned on 2009-04-29 |
high-throughput | Delom F, et al. (2006) The plasma membrane proteome of Saccharomyces cerevisiae and its response to the antifungal calcofluor. Proteomics 6(10):3029-39 |
SGD |
| ADH1/YOL086C | IDA: Inferred from Direct Assay Assigned on 2009-04-29 |
high-throughput | Delom F, et al. (2006) The plasma membrane proteome of Saccharomyces cerevisiae and its response to the antifungal calcofluor. Proteomics 6(10):3029-39 |
SGD |
| ADY2/YCR010C | IDA: Inferred from Direct Assay Assigned on 2007-04-05 |
manually curated | Ricicova M, et al. (2007) Association of putative ammonium exporters Ato with detergent-resistant compartments of plasma membrane during yeast colony development: pH affects Ato1p localisation in patches. Biochim Biophys Acta 1768(5):1170-1178 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2009-04-29 |
high-throughput | Delom F, et al. (2006) The plasma membrane proteome of Saccharomyces cerevisiae and its response to the antifungal calcofluor. Proteomics 6(10):3029-39 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AFI1/YOR129C | IMP: Inferred from Mutant Phenotype Assigned on 2008-04-15 |
manually curated | Wysocka M, et al. (2003) YOR129c, a new element interacting with Cnm67p, a component of the spindle pole body of Saccharomyces cerevisiae. Acta Biochim Pol 50(3):883-90 |
SGD |
| IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2008-04-15 |
manually curated | Tsai PC, et al. (2008) Afi1p Functions as an Arf3p Polarization-specific Docking Factor for Development of Polarity. J Biol Chem 283(24):16915-27 |
SGD | |
| AGP1/YCL025C | ISS: Inferred from Sequence or structural Similarity Assigned on 2002-08-05 |
manually curated | Regenberg B, et al. (1999) Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Curr Genet 36(6):317-28 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AGP3/YFL055W | ISS: Inferred from Sequence or structural Similarity Assigned on 2002-10-02 |
manually curated | Regenberg B, et al. (1999) Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Curr Genet 36(6):317-28 |
SGD |
| AHP1/YLR109W | IDA: Inferred from Direct Assay Assigned on 2009-04-29 |
high-throughput | Delom F, et al. (2006) The plasma membrane proteome of Saccharomyces cerevisiae and its response to the antifungal calcofluor. Proteomics 6(10):3029-39 |
SGD |
| AIF1/YNR074C | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-12-28 |
manually curated | Ververidis P, et al. (2001) A novel putative reductase (Cpd1p) and the multidrug exporter Snq2p are involved in resistance to cercosporin and other singlet oxygen-generating photosensitizers in Saccharomyces cerevisiae. Curr Genet 39(3):127-36 |
SGD |
| ALP1/YNL270C | ISS: Inferred from Sequence or structural Similarity Assigned on 2002-08-05 |
manually curated | Regenberg B, et al. (1999) Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae. Curr Genet 36(6):317-28 |
SGD |
| ALR1/YOL130W | IMP: Inferred from Mutant Phenotype Assigned on 2001-04-12 |
manually curated | MacDiarmid CW and Gardner RC (1998) Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion. J Biol Chem 273(3):1727-32 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2011-08-04 |
manually curated | Lim PH, et al. (2011) Regulation of alr1 mg transporter activity by intracellular magnesium. PLoS One 6(6):e20896 |
SGD | |
| ALR2/YFL050C | IMP: Inferred from Mutant Phenotype Assigned on 2001-04-12 |
manually curated | MacDiarmid CW and Gardner RC (1998) Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion. J Biol Chem 273(3):1727-32 |
SGD |
| ANS1/YHR126C | IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| APL1/YJR005W | IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| APL2/YKL135C | IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| APL3/YBL037W | IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| APS2/YJR058C | IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AQR1/YNL065W | IDA: Inferred from Direct Assay Assigned on 2002-12-12 |
manually curated | Tenreiro S, et al. (2002) AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae. Biochem Biophys Res Commun 292(3):741-8 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2012-12-12 |
high-throughput | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
SGD | |
| AQY1/YPR192W | IDA: Inferred from Direct Assay Assigned on 2003-01-08 |
manually curated | Laize V, et al. (1999) Molecular and functional study of AQY1 from Saccharomyces cerevisiae: role of the C-terminal domain. Biochem Biophys Res Commun 257(1):139-44 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AQY2/YLL052C | IDA: Inferred from Direct Assay Assigned on 2003-01-08 |
manually curated | Meyrial V, et al. (2001) Existence of a tightly regulated water channel in Saccharomyces cerevisiae. Eur J Biochem 268(2):334-43 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ARN1/YHL040C | IDA: Inferred from Direct Assay Assigned on 2009-06-30 |
manually curated | Kim Y, et al. (2005) A receptor domain controls the intracellular sorting of the ferrichrome transporter, ARN1. EMBO J 24(5):952-62 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ARN2/YHL047C | ISS: Inferred from Sequence or structural Similarity Assigned on 2002-03-14 |
manually curated | Heymann P, et al. (1999) Identification of a fungal triacetylfusarinine C siderophore transport gene (TAF1) in Saccharomyces cerevisiae as a member of the major facilitator superfamily. Biometals 12(4):301-6 |
SGD |
| ARP3/YJR065C | IDA: Inferred from Direct Assay Assigned on 2009-04-29 |
high-throughput | Delom F, et al. (2006) The plasma membrane proteome of Saccharomyces cerevisiae and its response to the antifungal calcofluor. Proteomics 6(10):3029-39 |
SGD |
| ARR3/YPR201W | IDA: Inferred from Direct Assay Assigned on 2010-08-12 |
manually curated | Maciaszczyk-Dziubinska E, et al. (2010) The yeast permease Acr3p is a dual arsenite and antimonite plasma membrane transporter. Biochim Biophys Acta 1798(11):2170-5 |
SGD |
| ASG7/YJL170C | IDA: Inferred from Direct Assay Assigned on 2002-09-16 |
manually curated | Kim J, et al. (2000) Localization and signaling of G(beta) subunit Ste4p are controlled by a-factor receptor and the a-specific protein Asg7p. Mol Cell Biol 20(23):8826-35 |
SGD |
| AST1/YBL069W | IDA: Inferred from Direct Assay Assigned on 2012-05-10 |
manually curated | Bagnat M, et al. (2001) Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast. Mol Biol Cell 12(12):4129-38 |
SGD |
| ATO2/YNR002C | IDA: Inferred from Direct Assay Assigned on 2007-04-05 |
manually curated | Ricicova M, et al. (2007) Association of putative ammonium exporters Ato with detergent-resistant compartments of plasma membrane during yeast colony development: pH affects Ato1p localisation in patches. Biochim Biophys Acta 1768(5):1170-1178 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ATO3/YDR384C | IDA: Inferred from Direct Assay Assigned on 2003-12-28 |
manually curated | Guaragnella N and Butow RA (2003) ATO3 encoding a putative outward ammonium transporter is an RTG-independent retrograde responsive gene regulated by GCN4 and the Ssy1-Ptr3-Ssy5 amino acid sensor system. J Biol Chem 278(46):45882-7 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ATR1/YML116W | IDA: Inferred from Direct Assay Assigned on 2009-05-13 |
manually curated | Kaya A, et al. (2009) Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast. Mol Cell Biol 29(13):3665-74 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2002-07-12 |
manually curated | Gompel-Klein P and Brendel M (1990) Allelism of SNQ1 and ATR1, genes of the yeast Saccharomyces cerevisiae required for controlling sensitivity to 4-nitroquinoline-N-oxide and aminotriazole. Curr Genet 18(1):93-6 |
SGD | |
| AUS1/YOR011W | IDA: Inferred from Direct Assay Assigned on 2011-05-16 |
manually curated | Marek M, et al. (2011) The yeast plasma membrane ATP binding cassette (ABC) transporter Aus1: purification, characterization, and the effect of lipids on its activity. J Biol Chem 286(24):21835-43 |
SGD |
| AVO1/YOL078W | IDA: Inferred from Direct Assay Assigned on 2009-01-21 |
manually curated | Berchtold D and Walther TC (2009) TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain. Mol Biol Cell 20(5):1565-75 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
