GO term: endoplasmic reticulum Help



Ontology: Cellular Component (GO:0005783)

Definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

Synonyms: ER

View Ontology: GO Tree Graph (graph) | Amigo (text)

Annotation Summary


This table lists the methods used to annotate genes either directly to the term endoplasmic reticulum (435 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method GO Term # Yeast Genes Annotated
Manually curated (download data) endoplasmic reticulum 139
NOT: endoplasmic reticulum 1
High-throughput (download data) endoplasmic reticulum 123
Computational (download data) endoplasmic reticulum 364

Links to Additional Annotations:
Genes Annotated with this Term
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Annotation details for genes that have been directly annotated to the term endoplasmic reticulum or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

endoplasmic reticulum
     435 genes directly annotated to this term
Locus Evidence Annotation Method Reference Assigned By
ACC1/YNR016C IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ACS1/YAL054C IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ADP1/YCR011C IDA: Inferred from Direct Assay
Assigned on 2002-05-07
high-throughput Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALE1/YOR175C IDA: Inferred from Direct Assay
Assigned on 2007-10-23
manually curated Tamaki H, et al.  (2007) LPT1 Encodes a Membrane-bound O-Acyltransferase Involved in the Acylation of Lysophospholipids in the Yeast Saccharomyces cerevisiae. J Biol Chem 282(47):34288-98 SGD
IDA: Inferred from Direct Assay
Assigned on 2003-10-28
high-throughput Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG1/YBR110W IPI: Inferred from Physical Interaction
with SGD:ALG11
Assigned on 2005-03-01
manually curated Gao XD, et al.  (2004) Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum. Glycobiology 14(6):559-70 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG11/YNL048W IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG12/YNR030W IDA: Inferred from Direct Assay
Assigned on 2003-10-28
high-throughput Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG13/YGL047W IDA: Inferred from Direct Assay
Assigned on 2003-10-28
high-throughput Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0095
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ALG14/YBR070C IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG2/YGL065C TAS: Traceable Author Statement
Assigned on 2002-11-15
manually curated Cipollo JF, et al.  (2001) The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum. J Biol Chem 276(24):21828-40 SGD
IC: Inferred By Curator
from oligosaccharide-lipid intermediate biosynthetic process
Assigned on 2007-04-17
manually curated O'Reilly MK, et al.  (2006) In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis. Biochemistry 45(31):9593-603 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG3/YBL082C IMP: Inferred from Mutant Phenotype,
ISS: Inferred from Sequence or structural Similarity
Assigned on 2002-11-14
manually curated Aebi M, et al.  (1996) Cloning and characterization of the ALG3 gene of Saccharomyces cerevisiae. Glycobiology 6(4):439-44 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR007873
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG5/YPL227C IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG6/YOR002W IMP: Inferred from Mutant Phenotype
Assigned on 2002-08-30
manually curated Reiss G, et al.  (1996) Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway. Glycobiology 6(5):493-8 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG7/YBR243C IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG8/YOR067C IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ALG9/YNL219C IMP: Inferred from Mutant Phenotype,
ISS: Inferred from Sequence or structural Similarity
Assigned on 2002-11-15
manually curated Burda P, et al.  (1996) Stepwise assembly of the lipid-linked oligosaccharide in the endoplasmic reticulum of Saccharomyces cerevisiae: identification of the ALG9 gene encoding a putative mannosyl transferase. Proc Natl Acad Sci U S A 93(14):7160-5 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ANP1/YEL036C IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
APQ12/YIL040W IDA: Inferred from Direct Assay
Assigned on 2003-10-28
high-throughput Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
AQY1/YPR192W IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
AQY2/YLL052C IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ARE1/YCR048W IDA: Inferred from Direct Assay
Assigned on 2002-09-06
manually curated Zweytick D, et al.  (2000) Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem 267(4):1075-82 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ARE2/YNR019W IDA: Inferred from Direct Assay
Assigned on 2002-09-06
manually curated Zweytick D, et al.  (2000) Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem 267(4):1075-82 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ARV1/YLR242C IDA: Inferred from Direct Assay
Assigned on 2003-01-23
manually curated Swain E, et al.  (2002) Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. J Biol Chem 277(39):36152-60 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
ASP3-1/YLR155C IDA: Inferred from Direct Assay
Assigned on 2002-05-07
high-throughput Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 SGD
ATF2/YGR177C IDA: Inferred from Direct Assay
Assigned on 2003-10-28
high-throughput Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD
ATG15/YCR068W IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
AVT2/YEL064C IDA: Inferred from Direct Assay
Assigned on 2006-07-24
manually curated Russnak R, et al.  (2001) A family of yeast proteins mediating bidirectional vacuolar amino acid transport. J Biol Chem 276(26):23849-57 SGD
AYR1/YIL124W IDA: Inferred from Direct Assay
Assigned on 2001-01-18
manually curated Athenstaedt K and Daum G  (2000) 1-Acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles. J Biol Chem 275(1):235-40 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0095
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
BET1/YIL004C IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
BET3/YKR068C IEA: Inferred from Electronic Annotation
with EBI:KW-0256
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0095
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB

NOT: endoplasmic reticulum
     1 gene directly annotated to this term
Locus Evidence Annotation Method Reference Assigned By
CHO1/YER026C IDA: Inferred from Direct Assay
Assigned on 2012-08-09
manually curated Zinser E, et al.  (1991) Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eukaryote Saccharomyces cerevisiae. J Bacteriol 173(6):2026-34 SGD