GO term: endoplasmic reticulum 
Ontology: Cellular Component (GO:0005783)
Definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
Synonyms: ER
Definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
Synonyms: ER
This table lists the methods used to annotate genes either directly to the term
endoplasmic reticulum (413 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | endoplasmic reticulum | 140 |
| High-throughput (download data) | endoplasmic reticulum | 110 |
| Computational (download data) | endoplasmic reticulum | 333 |
Links to Additional Annotations:
Annotation details for genes that have been directly annotated to the term
endoplasmic reticulum or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| endoplasmic reticulum 413 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ACS1/YAL054C | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| ADP1/YCR011C | IDA: Inferred from Direct Assay Assigned on 2002-05-07 |
high-throughput | Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| AIM27/YKL207W | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| ALE1/YOR175C | IDA: Inferred from Direct Assay Assigned on 2007-10-23 |
manually curated | Tamaki H, et al. (2007) LPT1 Encodes a Membrane-bound O-Acyltransferase Involved in the Acylation of Lysophospholipids in the Yeast Saccharomyces cerevisiae. J Biol Chem 282(47):34288-98 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ALG1/YBR110W | IPI: Inferred from Physical Interaction with SGD:ALG11 Assigned on 2005-03-01 |
manually curated | Gao XD, et al. (2004) Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum. Glycobiology 14(6):559-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ALG11/YNL048W | IDA: Inferred from Direct Assay Assigned on 2001-06-22 |
manually curated | Cipollo JF, et al. (2001) The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum. J Biol Chem 276(24):21828-40 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ALG12/YNR030W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ALG13/YGL047W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0095 Last Updated 2009-10-01 |
computational | GOA curators and UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. |
UniProtKB | |
| ALG14/YBR070C | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| ALG2/YGL065C | TAS: Traceable Author Statement Assigned on 2002-11-15 |
manually curated | Cipollo JF, et al. (2001) The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum. J Biol Chem 276(24):21828-40 |
SGD |
| IC: Inferred By Curator from oligosaccharide-lipid intermediate assembly Assigned on 2007-04-17 |
manually curated | O'Reilly MK, et al. (2006) In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis. Biochemistry 45(31):9593-603 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ALG3/YBL082C | IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-11-14 |
manually curated | Aebi M, et al. (1996) Cloning and characterization of the ALG3 gene of Saccharomyces cerevisiae. Glycobiology 6(4):439-44 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR007873 Last Updated 2009-10-01 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ALG5/YPL227C | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| ALG6/YOR002W | IMP: Inferred from Mutant Phenotype Assigned on 2002-08-30 |
manually curated | Reiss G, et al. (1996) Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway. Glycobiology 6(5):493-8 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ALG7/YBR243C | IC: Inferred By Curator from protein amino acid N-linked glycosylation Assigned on 2002-11-13 |
manually curated | Burda P and Aebi M (1999) The dolichol pathway of N-linked glycosylation. Biochim Biophys Acta 1426(2):239-57 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ALG8/YOR067C | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| ALG9/YNL219C | IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-11-15 |
manually curated | Burda P, et al. (1996) Stepwise assembly of the lipid-linked oligosaccharide in the endoplasmic reticulum of Saccharomyces cerevisiae: identification of the ALG9 gene encoding a putative mannosyl transferase. Proc Natl Acad Sci U S A 93(14):7160-5 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ANP1/YEL036C | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| APQ12/YIL040W | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| AQY1/YPR192W | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| ARE1/YCR048W | IDA: Inferred from Direct Assay Assigned on 2002-09-06 |
manually curated | Zweytick D, et al. (2000) Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem 267(4):1075-82 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ARE2/YNR019W | IDA: Inferred from Direct Assay Assigned on 2002-09-06 |
manually curated | Zweytick D, et al. (2000) Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem 267(4):1075-82 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ARV1/YLR242C | IDA: Inferred from Direct Assay Assigned on 2003-01-23 |
manually curated | Swain E, et al. (2002) Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. J Biol Chem 277(39):36152-60 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| ASP3-1/YLR155C | IDA: Inferred from Direct Assay Assigned on 2002-05-07 |
high-throughput | Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 |
SGD |
| ATF2/YGR177C | IDA: Inferred from Direct Assay Assigned on 2003-10-28 |
high-throughput | Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 |
SGD |
| ATG15/YCR068W | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| AVT2/YEL064C | IDA: Inferred from Direct Assay Assigned on 2006-07-24 |
manually curated | Russnak R, et al. (2001) A family of yeast proteins mediating bidirectional vacuolar amino acid transport. J Biol Chem 276(26):23849-57 |
SGD |
| AYR1/YIL124W | IDA: Inferred from Direct Assay Assigned on 2001-01-18 |
manually curated | Athenstaedt K and Daum G (2000) 1-Acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles. J Biol Chem 275(1):235-40 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB | |
| IEA: Inferred from Electronic Annotation with EBI:SL-0095 Last Updated 2009-10-01 |
computational | GOA curators and UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. |
UniProtKB | |
| BET1/YIL004C | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| BET3/YKR068C | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0095 Last Updated 2009-10-01 |
computational | GOA curators and UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. |
UniProtKB | |
| BET5/YML077W | IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2009-10-01 |
computational | GOA curators (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. |
UniProtKB |
| IEA: Inferred from Electronic Annotation with EBI:SL-0095 Last Updated 2009-10-01 |
computational | GOA curators and UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. |
UniProtKB | |
This diagram shows the local area of the Gene Ontology and the numbers of yeast genes annotated to each term in the diagram. Within the diagram, click on the blue arrow to navigate up the tree and click on a GO term name to go to its GO term page.
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