Ontology: Cellular Component (GO:0005783)

Definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

Synonyms: ER

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term endoplasmic reticulum (435 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	endoplasmic reticulum	139
	NOT: endoplasmic reticulum	1
High-throughput (download data)	endoplasmic reticulum	123
Computational (download data)	endoplasmic reticulum	364

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term endoplasmic reticulum or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

endoplasmic reticulum      435 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ACC1/YNR016C	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ACS1/YAL054C	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ADP1/YCR011C	IDA: Inferred from Direct Assay Assigned on 2002-05-07	high-throughput	Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALE1/YOR175C	IDA: Inferred from Direct Assay Assigned on 2007-10-23	manually curated	Tamaki H, et al.  (2007) LPT1 Encodes a Membrane-bound O-Acyltransferase Involved in the Acylation of Lysophospholipids in the Yeast Saccharomyces cerevisiae. J Biol Chem 282(47):34288-98	SGD
	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG1/YBR110W	IPI: Inferred from Physical Interaction with SGD:ALG11 Assigned on 2005-03-01	manually curated	Gao XD, et al.  (2004) Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum. Glycobiology 14(6):559-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG11/YNL048W	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG12/YNR030W	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG13/YGL047W	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0095 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG14/YBR070C	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG2/YGL065C	TAS: Traceable Author Statement Assigned on 2002-11-15	manually curated	Cipollo JF, et al.  (2001) The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum. J Biol Chem 276(24):21828-40	SGD
	IC: Inferred By Curator from oligosaccharide-lipid intermediate biosynthetic process Assigned on 2007-04-17	manually curated	O'Reilly MK, et al.  (2006) In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis. Biochemistry 45(31):9593-603	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG3/YBL082C	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-11-14	manually curated	Aebi M, et al.  (1996) Cloning and characterization of the ALG3 gene of Saccharomyces cerevisiae. Glycobiology 6(4):439-44	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR007873 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG5/YPL227C	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG6/YOR002W	IMP: Inferred from Mutant Phenotype Assigned on 2002-08-30	manually curated	Reiss G, et al.  (1996) Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway. Glycobiology 6(5):493-8	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG7/YBR243C	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG8/YOR067C	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ALG9/YNL219C	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2002-11-15	manually curated	Burda P, et al.  (1996) Stepwise assembly of the lipid-linked oligosaccharide in the endoplasmic reticulum of Saccharomyces cerevisiae: identification of the ALG9 gene encoding a putative mannosyl transferase. Proc Natl Acad Sci U S A 93(14):7160-5	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ANP1/YEL036C	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
APQ12/YIL040W	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
AQY1/YPR192W	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
AQY2/YLL052C	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ARE1/YCR048W	IDA: Inferred from Direct Assay Assigned on 2002-09-06	manually curated	Zweytick D, et al.  (2000) Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem 267(4):1075-82	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ARE2/YNR019W	IDA: Inferred from Direct Assay Assigned on 2002-09-06	manually curated	Zweytick D, et al.  (2000) Contribution of Are1p and Are2p to steryl ester synthesis in the yeast Saccharomyces cerevisiae. Eur J Biochem 267(4):1075-82	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ARV1/YLR242C	IDA: Inferred from Direct Assay Assigned on 2003-01-23	manually curated	Swain E, et al.  (2002) Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1. J Biol Chem 277(39):36152-60	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ASP3-1/YLR155C	IDA: Inferred from Direct Assay Assigned on 2002-05-07	high-throughput	Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19	SGD
ATF2/YGR177C	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
ATG15/YCR068W	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
AVT2/YEL064C	IDA: Inferred from Direct Assay Assigned on 2006-07-24	manually curated	Russnak R, et al.  (2001) A family of yeast proteins mediating bidirectional vacuolar amino acid transport. J Biol Chem 276(26):23849-57	SGD
AYR1/YIL124W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Athenstaedt K and Daum G  (2000) 1-Acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles. J Biol Chem 275(1):235-40	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0095 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
BET1/YIL004C	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
BET3/YKR068C	IEA: Inferred from Electronic Annotation with EBI:KW-0256 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0095 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB

NOT: endoplasmic reticulum      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
CHO1/YER026C	IDA: Inferred from Direct Assay Assigned on 2012-08-09	manually curated	Zinser E, et al.  (1991) Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eukaryote Saccharomyces cerevisiae. J Bacteriol 173(6):2026-34	SGD

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