GO term: mitochondrial inner membrane Help



Ontology: Cellular Component (GO:0005743)

Definition: The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

Synonyms: inner mitochondrial membrane

View Ontology: GO Tree Graph (graph) | Amigo (text)

Annotation Summary


This table lists the methods used to annotate genes either directly to the term mitochondrial inner membrane (217 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method GO Term # Yeast Genes Annotated
Manually curated (download data) colocalizes_with: mitochondrial inner membrane 1
mitochondrial inner membrane 96
High-throughput none none
Computational (download data) mitochondrial inner membrane 200

Links to Additional Annotations:
Genes Annotated with this Term
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Annotation details for genes that have been directly annotated to the term mitochondrial inner membrane or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

colocalizes_with: mitochondrial inner membrane
     1 gene directly annotated to this term
Locus Evidence Annotation Method Reference Assigned By
FZO1/YBR179C IDA: Inferred from Direct Assay
Assigned on 2005-05-10
manually curated Fritz S, et al.  (2001) Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion. J Cell Biol 152(4):683-92 SGD

mitochondrial inner membrane
     217 genes directly annotated to this term
Locus Evidence Annotation Method Reference Assigned By
AAC1/YMR056C IDA: Inferred from Direct Assay
Assigned on 2013-02-17
manually curated Dyall SD, et al.  (2003) The dynamic dimerization of the yeast ADP/ATP carrier in the inner mitochondrial membrane is affected by conserved cysteine residues. J Biol Chem 278(29):26757-64 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR002113
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
AAC3/YBR085W ISA: Inferred from Sequence Alignment
with SGD:AAC1, SGD:PET9
Assigned on 2008-04-16
manually curated Kolarov J, et al.  (1990) A third ADP/ATP translocator gene in yeast. J Biol Chem 265(21):12711-6 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR002113
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ADK2/YER170W IDA: Inferred from Direct Assay
Assigned on 2002-09-27
manually curated Schricker R, et al.  (1995) Strain-dependent occurrence of functional GTP:AMP phosphotransferase (AK3) in Saccharomyces cerevisiae. J Biol Chem 270(52):31103-10 SGD
IDA: Inferred from Direct Assay
Assigned on 2005-03-14
manually curated Gu Y, et al.  (2005) A GTP:AMP phosphotransferase, Adk2p, in Saccharomyces cerevisiae. Role of the C terminus in protein folding/stabilization, thermal tolerance, and enzymatic activity. J Biol Chem 280(19):18604-9 SGD
AEP3/YPL005W IDA: Inferred from Direct Assay
Assigned on 2004-04-27
manually curated Ellis TP, et al.  (2004) Aep3p stabilizes the mitochondrial bicistronic mRNA encoding subunits 6 and 8 of the H+-translocating ATP synthase of Saccharomyces cerevisiae. J Biol Chem 279(16):15728-33 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
AFG1/YEL052W IDA: Inferred from Direct Assay
Assigned on 2007-06-08
manually curated Khalimonchuk O, et al.  (2007) Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase. J Biol Chem 282(24):17442-9 SGD
AFG3/YER017C IDA: Inferred from Direct Assay
Assigned on 2001-01-18
manually curated Tauer R, et al.  (1994) Yta10p, a member of a novel ATPase family in yeast, is essential for mitochondrial function. FEBS Lett 353(2):197-200 SGD
AGC1/YPR021C ISS: Inferred from Sequence or structural Similarity
with SGD:PET9
Assigned on 2007-06-20
manually curated Belenkiy R, et al.  (2000) The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins. Biochim Biophys Acta 1467(1):207-18 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
AIM13/YFR011C IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
AIM37/YNL100W IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
AIM5/YBR262C IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ARH1/YDR376W IDA: Inferred from Direct Assay
Assigned on 2002-08-20
manually curated Lacour T, et al.  (1998) Characterization of recombinant adrenodoxin reductase homologue (Arh1p) from yeast. Implication in in vitro cytochrome p45011beta monooxygenase system. J Biol Chem 273(37):23984-92 SGD
ATM1/YMR301C IDA: Inferred from Direct Assay
Assigned on 2001-01-18
manually curated Leighton J and Schatz G  (1995) An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast. EMBO J 14(1):188-95 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP1/YBL099W IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP10/YLR393W IPI: Inferred from Physical Interaction
with SGD:ATP6
Assigned on 2008-02-04
manually curated Tzagoloff A, et al.  (2004) Atp10p assists assembly of Atp6p into the F0 unit of the yeast mitochondrial ATPase. J Biol Chem 279(19):19775-80 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR007849
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP14/YLR295C IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP15/YPL271W IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP16/YDL004W IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP17/YDR377W IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP19/YOL077W-A IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP2/YJR121W IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP22/YDR350C IDA: Inferred from Direct Assay
Assigned on 2003-06-18
manually curated Helfenbein KG, et al.  (2003) ATP22, a nuclear gene required for expression of the F0 sector of mitochondrial ATPase in Saccharomyces cerevisiae. J Biol Chem 278(22):19751-6 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR017207
Last Updated 2013-03-02
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. InterPro
IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP23/YNR020C IDA: Inferred from Direct Assay
Assigned on 2007-02-14
manually curated Zeng X, et al.  (2007) The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase. Mol Biol Cell 18(2):617-26 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP25/YMR098C IDA: Inferred from Direct Assay
Assigned on 2008-04-01
manually curated Zeng X, et al.  (2008) ATP25, a New Nuclear Gene of Saccharomyces cerevisiae Required for Expression and Assembly of the Atp9p Subunit of Mitochondrial ATPase. Mol Biol Cell 19(4):1366-77 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP3/YBR039W IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP4/YPL078C IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP5/YDR298C IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP6/Q0085 IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
ATP7/YKL016C IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
BCS1/YDR375C IDA: Inferred from Direct Assay
Assigned on 2001-01-18
manually curated Folsch H, et al.  (1996) Internal targeting signal of the BCS1 protein: a novel mechanism of import into mitochondria. EMBO J 15(3):479-87 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB
BI2/Q0110 IEA: Inferred from Electronic Annotation
with EBI:KW-0999
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0168
Last Updated 2013-03-02
computational UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. UniProtKB