GO term: mitochondrion Help


Ontology: Cellular Component (GO:0005739)

Definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Synonyms: mitochondria

Annotation Summary


This table lists the methods used to annotate genes either directly to the term mitochondrion (1099 genes) or to its variants containing one or more qualifiers (2 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method GO Term # Yeast Genes Annotated
Manually curated (download data) mitochondrion 297
NOT: mitochondrion 2
High-throughput (download data) mitochondrion 915
Computational (download data) mitochondrion 682

Links to Additional Annotations:
Genes Annotated with this Term


Annotation details for genes that have been directly annotated to the term mitochondrion or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

mitochondrion
     1099 genes directly annotated to this term
Locus Evidence Annotation Method Reference Assigned By
AAC1/YMR056C IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
AAC3/YBR085W IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
AAT1/YKL106W TAS: Traceable Author Statement
Assigned on 2001-01-18
manually curated Morin PJ, et al.  (1992) AAT1, a gene encoding a mitochondrial aspartate aminotransferase in Saccharomyces cerevisiae. Biochim Biophys Acta 1171(2):211-4 SGD
IDA: Inferred from Direct Assay
Assigned on 2004-09-28
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
ABC1/YGL119W IDA: Inferred from Direct Assay
Assigned on 2003-02-04
manually curated Do TQ, et al.  (2001) A defect in coenzyme Q biosynthesis is responsible for the respiratory deficiency in Saccharomyces cerevisiae abc1 mutants. J Biol Chem 276(21):18161-8 SGD
ISS: Inferred from Sequence or structural Similarity
Assigned on 2003-05-23
manually curated Bousquet I, et al.  (1991) ABC1, a novel yeast nuclear gene has a dual function in mitochondria: it suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex. EMBO J 10(8):2023-31 SGD
IDA: Inferred from Direct Assay
Assigned on 2004-09-24
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
ABF2/YMR072W IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
ACC1/YNR016C IDA: Inferred from Direct Assay
Assigned on 2004-09-28
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
ACH1/YBL015W IDA: Inferred from Direct Assay
Assigned on 2003-05-19
manually curated Buu LM, et al.  (2003) Functional characterization and localization of acetyl-CoA hydrolase, Ach1p, in Saccharomyces cerevisiae. J Biol Chem 278(19):17203-9 SGD
IDA: Inferred from Direct Assay
Assigned on 2004-09-24
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
ACK1/YDL203C IDA: Inferred from Direct Assay
Assigned on 2004-08-13
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
ACN9/YDR511W IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:IPR008381
Last Updated 2009-11-20
computational DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
ACO1/YLR304C IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
ACO2/YJL200C IDA: Inferred from Direct Assay
Assigned on 2003-10-28
high-throughput Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD
IDA: Inferred from Direct Assay
Assigned on 2003-12-10
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
ACP1/YKL192C IDA: Inferred from Direct Assay
Assigned on 2004-09-28
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
ACS1/YAL054C IDA: Inferred from Direct Assay
Assigned on 2004-09-28
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
ADH3/YMR083W IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
ADH4/YGL256W IDA: Inferred from Direct Assay
Assigned on 2010-02-01
manually curated Perocchi F, et al.  (2006) Assessing Systems Properties of Yeast Mitochondria through an Interaction Map of the Organelle. PLoS Genet 2(10):e170 SGD
IDA: Inferred from Direct Assay
Assigned on 2003-10-28
high-throughput Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
ADK1/YDR226W IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
ADK2/YER170W IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
ADY2/YCR010C IDA: Inferred from Direct Assay
Assigned on 2004-09-28
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
AEP1/YMR064W IDA: Inferred from Direct Assay
Assigned on 2003-10-28
high-throughput Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
AEP2/YMR282C IDA: Inferred from Direct Assay
Assigned on 2008-11-20
manually curated Finnegan PM, et al.  (1995) The mature AEP2 gene product of Saccharomyces cerevisiae, required for the expression of subunit 9 of ATP synthase, is a 58 kDa mitochondrial protein. FEBS Lett 368(3):505-8 SGD
IDA: Inferred from Direct Assay
Assigned on 2004-09-28
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
AEP3/YPL005W IDA: Inferred from Direct Assay
Assigned on 2003-10-28
high-throughput Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
AFG1/YEL052W IDA: Inferred from Direct Assay
Assigned on 2003-10-28
high-throughput Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD
IDA: Inferred from Direct Assay
Assigned on 2004-09-24
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
AFG3/YER017C IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
AFT2/YPL202C IDA: Inferred from Direct Assay
Assigned on 2004-09-28
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
AGC1/YPR021C IDA: Inferred from Direct Assay
Assigned on 2007-06-21
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
AGX1/YFL030W IDA: Inferred from Direct Assay
Assigned on 2004-09-23
high-throughput Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD
IDA: Inferred from Direct Assay
Assigned on 2006-12-12
high-throughput Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD
AI1/Q0050 TAS: Traceable Author Statement
Assigned on 2002-10-24
manually curated Anziano PQ and Butow RA  (1991) Splicing-defective mutants of the yeast mitochondrial COXI gene can be corrected by transformation with a hybrid maturase gene. Proc Natl Acad Sci U S A 88(13):5592-6 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
AI2/Q0055 TAS: Traceable Author Statement
Assigned on 2002-10-24
manually curated Anziano PQ and Butow RA  (1991) Splicing-defective mutants of the yeast mitochondrial COXI gene can be corrected by transformation with a hybrid maturase gene. Proc Natl Acad Sci U S A 88(13):5592-6 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
AI3/Q0060 TAS: Traceable Author Statement
Assigned on 2002-11-18
manually curated Guo WW, et al.  (1995) The mobile group I intron 3 alpha of the yeast mitochondrial COXI gene encodes a 35-kDa processed protein that is an endonuclease but not a maturase. J Biol Chem 270(26):15563-70 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB
AI4/Q0065 TAS: Traceable Author Statement
Assigned on 2002-11-14
manually curated Henke RM, et al.  (1995) Maturase and endonuclease functions depend on separate conserved domains of the bifunctional protein encoded by the group I intron aI4 alpha of yeast mitochondrial DNA. EMBO J 14(20):5094-9 SGD
IEA: Inferred from Electronic Annotation
with EBI:KW-0496
Last Updated 2009-11-20
computational GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping. UniProtKB
IEA: Inferred from Electronic Annotation
with EBI:SL-0173
Last Updated 2009-11-20
computational GOA curators and UniProt curators  (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. UniProtKB

NOT: mitochondrion
     2 genes directly annotated to this term
Locus Evidence Annotation Method Reference Assigned By
NAM7/YMR080C IDA: Inferred from Direct Assay
Assigned on 2005-03-01
manually curated de Pinto B, et al.  (2004) Overexpression of Upf1p compensates for mitochondrial splicing deficiency independently of its role in mRNA surveillance. Mol Microbiol 51(4):1129-42 SGD
NBP35/YGL091C IDA: Inferred from Direct Assay
Assigned on 2006-10-31
manually curated Hausmann A, et al.  (2005) The eukaryotic P loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery. Proc Natl Acad Sci U S A 102(9):3266-71 SGD

Graphical Display


This diagram shows the local area of the Gene Ontology and the numbers of yeast genes annotated to each term in the diagram. Within the diagram, click on the blue arrow to navigate up the tree and click on a GO term name to go to its GO term page.

View term lineage as a textual display using Amigo

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