Ontology: Cellular Component (GO:0005737)

Definition: All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term cytoplasm (2254 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	cytoplasm	452
	NOT: cytoplasm	1
High-throughput (download data)	cytoplasm	1167
Computational (download data)	cytoplasm	1629

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term cytoplasm or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

NOT: cytoplasm      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ESF2/YNR054C	IDA: Inferred from Direct Assay Assigned on 2005-08-15	manually curated	Hoang T, et al.  (2005) Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Mol Cell Biol 25(13):5523-34	SGD

cytoplasm      2254 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
AAH1/YNL141W	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with HAMAP:MF_03145 Last Updated 2013-03-02	computational	Swiss Institute of Bioinformatics (SIB) curators and GOA curators  (2006) Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
AAP1/YHR047C	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
AAR2/YBL074C	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
AAT2/YLR027C	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ABP1/YCR088W	IDA: Inferred from Direct Assay Assigned on 2002-05-07	high-throughput	Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ABP140/YOR239W	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ABZ1/YNR033W	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ABZ2/YMR289W	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ACB1/YGR037C	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
ACC1/YNR016C	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ACE2/YLR131C	IDA: Inferred from Direct Assay Assigned on 2012-12-12	high-throughput	Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76	SGD
ACF2/YLR144C	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ACH1/YBL015W	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ACM1/YPL267W	IDA: Inferred from Direct Assay Assigned on 2008-08-22	manually curated	Enquist-Newman M, et al.  (2008) Modulation of the Mitotic Regulatory Network by APC-Dependent Destruction of the Cdh1 Inhibitor Acm1. Mol Cell 30(4):437-46	SGD
ACO1/YLR304C	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ACS1/YAL054C	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ACS2/YLR153C	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ACT1/YFL039C	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
ADD37/YMR184W	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ADD66/YKL206C	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ADE1/YAR015W	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
ADE12/YNL220W	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR001114 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with HAMAP:MF_03125 Last Updated 2013-03-02	computational	Swiss Institute of Bioinformatics (SIB) curators and GOA curators  (2006) Electronic Gene Ontology annotations created by transferring manual GO annotations between orthologous microbial proteins	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ADE2/YOR128C	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
ADE3/YGR204W	IDA: Inferred from Direct Assay Assigned on 2002-05-07	high-throughput	Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19	SGD
	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ADE4/YMR300C	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
ADE5,7/YGL234W	IDA: Inferred from Direct Assay Assigned on 2002-05-07	high-throughput	Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19	SGD
	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR004733 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ADE6/YGR061C	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ADE8/YDR408C	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
ADH1/YOL086C	IDA: Inferred from Direct Assay Assigned on 2013-03-19	manually curated	van Loon AP and Young ET  (1986) Intracellular sorting of alcohol dehydrogenase isoenzymes in yeast: a cytosolic location reflects absence of an amino-terminal targeting sequence for the mitochondrion. EMBO J 5(1):161-5	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
ADH2/YMR303C	IDA: Inferred from Direct Assay Assigned on 2002-05-07	high-throughput	Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19	SGD
	IDA: Inferred from Direct Assay Assigned on 2003-10-28	high-throughput	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB

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