Ontology: Cellular Component (GO:0005697)

Definition: Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term telomerase holoenzyme complex (4 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	telomerase holoenzyme complex	4
High-throughput	none	none
Computational (download data)	telomerase holoenzyme complex	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term telomerase holoenzyme complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

telomerase holoenzyme complex      4 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
EST1/YLR233C	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction Assigned on 2003-06-19	manually curated	Hughes TR, et al.  (2000) The Est3 protein is a subunit of yeast telomerase. Curr Biol 10(13):809-12	SGD
EST2/YLR318W	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction Assigned on 2003-06-19	manually curated	Hughes TR, et al.  (2000) The Est3 protein is a subunit of yeast telomerase. Curr Biol 10(13):809-12	SGD
EST3/YIL009C-A	IDA: Inferred from Direct Assay Assigned on 2003-06-19	manually curated	Hughes TR, et al.  (2000) The Est3 protein is a subunit of yeast telomerase. Curr Biol 10(13):809-12	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR019437 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
TLC1	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction Assigned on 2003-06-19	manually curated	Hughes TR, et al.  (2000) The Est3 protein is a subunit of yeast telomerase. Curr Biol 10(13):809-12	SGD

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