GO term: anaphase-promoting complex 
Ontology: Cellular Component (GO:0005680)
Definition: A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
Synonyms: anaphase promoting complex; APC; cyclosome
View Ontology:
(graph) | 
(text)
Definition: A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
Synonyms: anaphase promoting complex; APC; cyclosome
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
anaphase-promoting complex (16 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | anaphase-promoting complex | 16 |
| High-throughput | none | none |
| Computational (download data) | anaphase-promoting complex | 5 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
anaphase-promoting complex or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| anaphase-promoting complex 16 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AMA1/YGR225W | IPI: Inferred from Physical Interaction Assigned on 2002-08-07 |
manually curated | Cooper KF, et al. (2000) Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast. Proc Natl Acad Sci U S A 97(26):14548-53 |
SGD |
| APC1/YNL172W | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR024990 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| APC11/YDL008W | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR024991 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| APC2/YLR127C | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| APC4/YDR118W | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| APC5/YOR249C | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| APC9/YLR102C | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| CDC16/YKL022C | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| CDC20/YGL116W | IPI: Inferred from Physical Interaction with SGD:CDC23 Assigned on 2007-07-11 |
manually curated | Lim HH, et al. (1998) Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast. Curr Biol 8(4):231-4 |
SGD |
| CDC23/YHR166C | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR007192 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| CDC26/YFR036W | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR018860 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| CDC27/YBL084C | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| CDH1/YGL003C | IPI: Inferred from Physical Interaction with SGD:CDC23, SGD:CDC16 Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science 282(5394):1721-4 |
SGD |
| DOC1/YGL240W | IDA: Inferred from Direct Assay Assigned on 2007-07-11 |
manually curated | Zachariae W, et al. (1998) Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science 279(5354):1216-9 |
SGD |
| MND2/YIR025W | IDA: Inferred from Direct Assay Assigned on 2003-04-02 |
manually curated | Passmore LA, et al. (2003) Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J 22(4):786-96 |
SGD |
| IPI: Inferred from Physical Interaction Assigned on 2005-04-19 |
manually curated | Oelschlaegel T, et al. (2005) The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1. Cell 120(6):773-88 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR008402, EBI:IPR016807 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| SWM1/YDR260C | IDA: Inferred from Direct Assay Assigned on 2003-04-02 |
manually curated | Passmore LA, et al. (2003) Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition. EMBO J 22(4):786-96 |
SGD |
