Ontology: Cellular Component (GO:0005664)

Definition: A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.

Synonyms: eukaryotic ORC; nuclear ORC

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term nuclear origin of replication recognition complex (6 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	nuclear origin of replication recognition complex	6
High-throughput	none	none
Computational (download data)	nuclear origin of replication recognition complex	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term nuclear origin of replication recognition complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

nuclear origin of replication recognition complex      6 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ORC1/YML065W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-01-31	manually curated	Lee DG and Bell SP  (1997) Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol Cell Biol 17(12):7159-68	SGD
ORC2/YBR060C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-01-31	manually curated	Lee DG and Bell SP  (1997) Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol Cell Biol 17(12):7159-68	SGD
ORC3/YLL004W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-01-31	manually curated	Lee DG and Bell SP  (1997) Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol Cell Biol 17(12):7159-68	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR020795 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
ORC4/YPR162C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-01-31	manually curated	Lee DG and Bell SP  (1997) Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol Cell Biol 17(12):7159-68	SGD
ORC5/YNL261W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-01-31	manually curated	Lee DG and Bell SP  (1997) Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol Cell Biol 17(12):7159-68	SGD
ORC6/YHR118C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-01-31	manually curated	Lee DG and Bell SP  (1997) Architecture of the yeast origin recognition complex bound to origins of DNA replication. Mol Cell Biol 17(12):7159-68	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR008721 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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