Ontology: Cellular Component (GO:0005655)

Definition: A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.

Synonyms: nucleolar RNase P complex

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term nucleolar ribonuclease P complex (10 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	nucleolar ribonuclease P complex	10
High-throughput	none	none
Computational (download data)	nucleolar ribonuclease P complex	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term nucleolar ribonuclease P complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

nucleolar ribonuclease P complex      10 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
POP1/YNL221C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP3/YNL282W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IPI: Inferred from Physical Interaction with SGD:RPR1 Assigned on 2006-11-21	manually curated	Dichtl B and Tollervey D  (1997) Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo. EMBO J 16(2):417-29	SGD
POP4/YBR257W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR016848 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
POP5/YAL033W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP6/YGR030C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP7/YBR167C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP8/YBL018C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
RPP1/YHR062C	IDA: Inferred from Direct Assay Assigned on 2006-11-21	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IPI: Inferred from Physical Interaction with SGD:RPR1 Assigned on 2006-11-21	manually curated	Stolc V and Altman S  (1997) Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. Genes Dev 11(21):2926-37	SGD
RPR1	IDA: Inferred from Direct Assay Assigned on 2006-11-21	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-01-21	manually curated	Hsieh J, et al.  (2009) Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release. RNA 15(2):224-34	SGD
RPR2/YIR015W	IDA: Inferred from Direct Assay Assigned on 2001-09-06	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IDA: Inferred from Direct Assay Assigned on 2009-01-21	manually curated	Hsieh J, et al.  (2009) Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release. RNA 15(2):224-34	SGD

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